CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET

Ahsen Sevde Çınar; Suna Sibel Rızvanoğlu; Müjde Eryılmaz; Betül Demirci; Alev Önder

doi:10.33483/jfpau.1416623

Araştırma Makalesi

ENDEMİK SALVIA ABSCONDITIFLORA GREUTER & BURDET UÇUCU YAĞININ KİMYASAL İÇERİĞİ VE BİYOAKTİVİTELERİ

Yıl 2024, Cilt: 48 Sayı: 2, 19 - 19

Ahsen Sevde Çınar Suna Sibel Rızvanoğlu Müjde Eryılmaz Betül Demirci Alev Önder

https://doi.org/10.33483/jfpau.1416623

Öz

Amaç: Bu calışma, Türkiye'de doğal olarak yetişen Salvia absconditiflora Greuter & Burdet (endemik) uçucu yağının kimyasal bileşimini ve antibakteriyel, antibiyofilm ve anti-quorum sensing aktivitelerini belirlemeyi amaçlamıştır.
Gereç ve Yöntem: Bitkinin toprak üstü kısımlarından su distilasyonu yöntemi ile elde edilen uçucu yağın verimi (%0.4) belirlenmiş, GC-FID ve GC-MS cihazları ile kimyasal içeriği tayin edilmiştir. Ayrıca S. absconditiflora'dan elde edilen uçucu yağın antibakteriyel aktivitesi mikrodilüsyon yöntemi ile belirlenmiştir. Antibiyofilm aktivite için kristal viyole yöntemi ve anti-quorum sensing aktivite için raportör bakteri Chromobacterium violaceum ATCC 12472 kullanılmıştır.
Sonuç ve Tartışma: Uçucu yağın ana bileşenleri 1,8-sineol (%32.2), kafur (%13.6), α-pinen (%7.6), kamfen (%5.5) ve viridiflorol (%5.1) olarak belirlenmiştir. Uçucu yağ, Gram-pozitif bakterilerine karşı en iyi antibakteriyel aktiviteyi, Staphylococcus aureus suşlarına karşı 0,0078 (h/h) minimum inhibitör konsantrasyonu (MIC) ile göstermiştir. Ayrıca uçucu yağın biyofilm inhibisyon değeri %84.4 olarak belirlenmiştir. Chromobacterium violaceum ATCC 12472 suşunda viyolasin üretiminin engellenmesi de, olası anti-quorum sensing aktivitesinin varlığını göstermiştir. Yapılan çalışmaların sonucunda, S. absconditiflora uçucu yağının bakteriyel enfeksiyonlarla mücadelede umut verici bir alternatif olabileceği belirlenmiştir.

Anahtar Kelimeler

Antibakteriyel aktivite, antibiyofilm aktivite, anti-quorum sensing aktivite, Lamiaceae, Salvia absconditiflora, uçucu yağ

Kaynakça

1. Sofowora, A., Ogunbodede, E., Onayade, A. (2013). The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 210-229. [CrossRef]
2. Tako, E. (2020). Dietary plant-origin bio-active compounds, intestinal functionality, and microbiome. Nutrients, 12(11), 3223. [CrossRef]
3. Dhifi, W., Sana Bellili, S., Jazi, S., Bahloul, N., Wissem Mnif, W. (2016). Essential oils’ chemical characterization and investigation of some biological activities: A critical review. Medicines (Basel), 3(4), 25. [CrossRef]
4. Karpinski, T.M. (2020). Essential oils of Lamiaceae family plants as antifungals. Biomolecules, 10, 103. [CrossRef]
5. Standley, P., Williams, L. (1973). Labiatae. Fieldiana Botany, 24, p.237-317.
6. Davis, P.H. (1982). Flora of Turkey and the East Aegean Island. Vol. 7. Edinburgh University Press. p. 433-434.
7. Davis, P.H. (1988). Flora of Turkey and the East Aegean Island. Vol.10. Edinburgh University Press. p. 150-151.
8. Güner, A., Özhatay, N., Ekim, T., Baser, K.H.C. (2000). Flora of Turkey and the East Aegean Island. Vol. 11, Suppl. Edinburgh University Press. p. 141.
9. Abd Rashed, A., Rathi, D.N.G. (2021). Bioactive components of Salvia and their potential antidiabetic properties: A Review. Molecules, 26, 3042. [CrossRef]
10. Lopresti, A.L. (2017). Salvia (Sage): A Review of its potential cognitive-enhancing and protective effects. Drugs in R&D, 17(1), 53-64. [CrossRef]
11. Lu, Y., Foo, L.Y. (2002). Polyphenolics of Salvia-a review. Phytochemistry, 59(2), 117-40. [CrossRef]
12. Xu, J., Wei, K., Zhang, G., Lei, L., Yang, D., Wang, W., Han, Q., Xia, Y., Bi, Y., Yang, M., Yang, M., Li, M. (2018). Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review. Journal of Ethnopharmacology, 225, 18-30. [CrossRef]
13. Tosun, A., Khan, S., Kim, Y.S., Calín-Sánchez, Á., Hysenaj, X., Carbonell-Barrachina, A. (2014). Essential oil composition and anti-inflammatory activity of Salvia officinalis L (Lamiaceae) in murin macrophages. Tropical Journal of Pharmaceutical Research, 13(6), 937-942. [CrossRef]
14. Askari, S.F., Avan, R., Tayarani-Najaran, Z., Sahebkar, A., Eghbali, S. (2021). Iranian Salvia species: A phytochemical and pharmacological update. Phytochemistry, 183, 112619. [CrossRef]
15. Onder, A., Izgi, M.N., Cinar, A.S., Zengin, G., Yilmaz, M.A. (2022) The characterization of phenolic compounds via LC-ESI-MS/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: A comparative analysis. South African Journal of Botany, 150, 313-322. [CrossRef]
16. Bellomaria, B., Arnold, N., Valentine, G., Arnold, H.J. (1992). Contribution to the study of the essential oils from three species of Salvia growing wild in the eastern Mediterranean region. Journal of Essential Oil Research, 4, 607-614. [CrossRef]
17. Doğan, G., Hayta, Ş., Demirpolat, A., Bagci, E. (2017). Composition of the essential oil of endemic Salvia cryptantha Lamiaceae Montbret & Aucher Ex Bentham from Turkey. Hacettepe Journal of Biology and Chemistry, 45(3), 315-320. [CrossRef]
18. Kaya, A., Doğu, S., Demirci, B. (2022). Geographical impact on essential oil composition of endemic Salvia absconditiflora collected from different parts of Turkey. European Journal of Life Sciences, 1(2), 55-62. [CrossRef]
19. Demirpolat, A. (2023). Essential oil composition analysis, antimicrobial activities, and biosystematic studies on six species of Salvia. Life, 13(3), 634. [CrossRef]
20. Yilar, M., Bayar, Y., Bayar, A.A. (2020). Allelopathic and antifungal potentials of endemic Salvia absconditiflora Greuter & Burdet collected from different locations in Turkey. Allelopathy Journal, 49(2), 243-256. [CrossRef]
21. Islam, M.A., Islam, M., Hasan, R., Hossain, M.I., Nabi, A., Rahman, M., Goessens, W.H.F., Endtz, H.P., Boehm, A.B., Faruque, S.M. (2017). Environmental spread of NDM-1-producing multi-drug resistant bacteria in Dhaka, Bangladesh. Applied and Environmental Microbiology, 83. [CrossRef]
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23. Uroz, S., Dessaux, Y., Oger, P. (2009). Quorum sensing and quorum quenching: The yin and yang of bacterial communication. Chembiochem, 10(2), 205-216. [CrossRef]
24. Nithya, C., Begum, M.F., Pandian, S.K. (2010). Marine bacterial isolates inhibit biofilm formation and disrupt mature biofilms of Pseudomonas aeruginosa PAO1. Applied Microbiology and Biotechnology, 88(1), 341-358. [CrossRef]
25. Lagha, R., Ben Abdallah. F., Al-Sarhan, B.O., Al-Sodany, Y. (2019). Antibacterial and biofilm inhibitory activity of medicinal plant essential oils against Escherichia coli isolated from UTI patients. Molecules, 24(6), 1161. [CrossRef]
26. Çiçek Polat, D., Gümüşok, S., Rızvanoğlu, S.S., Eryılmaz, M. (2023). Bioactivities of Cotinus coggygria and its HPLC-DAD phenolic profiles, Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 157(5), 1061-1066. [CrossRef]
27. Wińska, K., Mączka, W., Łyczko, J., Grabarczyk, M., Czubaszek, A., Szumny, A. (2019). Essential oils as antimicrobial agents-myth or real alternative? Molecules, 24(11), 2130. [CrossRef]
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29. Hochmuth, D.H. (2008). MassFinder 4.0, Hochmuth Scientific Consulting. Hamburg, Germany. p. 1137-1144.
30. Clinical and Laboratory Standards Institute (CLSI) (2009). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. Wayne, PA, USA. p. 15-50.
31. Bali, E.B., Türkmen, K.E., Erdönmez, D., Sağlam, N. (2019). Comparative study of inhibitory potential of dietary phytochemicals against quorum sensing activity of and biofilm formation by Chromobacterium violaceum 12472, and swimming and swarming behaviour of Pseudomonas aeruginosa PAO1. Food Technology and Biotechnology, 57(2), 212-221. [CrossRef]
32. Eryılmaz, M., Kart, D., Gürpınar, S.S. (2019). Vajinal floradan izole edilen Lactobacillus sp. metabolitlerinin antibiyofilm aktivitelerinin araştırılması. Türk Mikrobiyoloji Cemiyeti Dergisi, 49(3), 169-174.
33. Jardak, M., Mnif, S., Ayed, R.B., Rezgui, F., Aifa, S. (2021). Chemical composition, antibiofilm activities of Tunisian spices essential oils, and combinatorial effect against Staphylococcus epidermidis biofilm. Lebensmittel-Wissenschaft & Technologie, 140, 110691. [CrossRef]
34. Gajdács, M., Spengler, G. (2020). Standard operating procedure (SOP) for disk diffusion-based quorum sensing inhibition assays. Acta Pharmaceutica Hungarica, 89, 117-125. [CrossRef]
35. Batohi, N., Lone, S.A., Marimani, M., Wani, M.Y., Al-Bogami, A.S., Ahmad, A. (2021). Citral, and its derivatives inhibit quorum sensing and biofilm formation in Chromobacterium violaceum. Archives of Microbiology, 203(4), 1451-1459. [CrossRef]
36. Bingöl, Ü., Cosge, B., Ipek, A., Gürbüz, B., Geven, F.G. (2009). Identification of essential oil components of Salvia cryptantha Montbret & Aucher ex Bentham, growing wild in Turkey. Asian Journal of Chemistry, 21(5), 3836-3840.
37. İpek, A., Gürbüz, B., Bingöl, M.Ü., Geven, F., Akgül, G., Afshar Pour Rezaeieh, K., Coşge, B. (2012). Comparison of essential oil components of wild and field grown Salvia cryptantha Montbert & Aucher ex Bentham, in Turkey. Turkish Journal of Agriculture and Forestry, 36, 668-672. [CrossRef]
38. Bagci, E., Vural, M., Dirmenci, T., Bruehl, L., Aitzetmüller, K. (2004). Fatty acid and tocochromanol patterns of some Salvia L. species. Zeitschrift fur Naturforschung-Section C Journal of Biosciences, 59(5-6), 305-309. [CrossRef]
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CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET

Yıl 2024, Cilt: 48 Sayı: 2, 19 - 19

Ahsen Sevde Çınar Suna Sibel Rızvanoğlu Müjde Eryılmaz Betül Demirci Alev Önder

https://doi.org/10.33483/jfpau.1416623

Öz

Objective: The study aimed to determine the chemical composition and antibacterial, antibiofilm, and anti-quorum sensing activities of the essential oil of Salvia absconditiflora Greuter & Burdet (an endemic species) growing wildly in Türkiye.
Material and Method: The essential oil from the aerial parts of the plant was obtained by hydro-distillation (0.4%) and analyzed by GC-FID and GC-MS. In addition, the broth microdilution method was used to determine antibacterial activity. The crystal violet assay was performed for antibiofilm activity, and the reporter bacteria Chromobacterium violaceum ATCC 12472 was used in the anti-quorum sensing activity test.
Result and Discussion: The major components of the essential oil were identified as 1,8-cineole (32.2%), camphor (13.6%), α-pinene (7.6%), camphene (5.5%), and viridiflorol (5.1%). The essential oil showed the best antibacterial activity against Gram-positive test bacteria, with a minimum inhibitory concentration (MIC) of 0.0078 (v/v) against Staphylococcus aureus strains. The percentage biofilm inhibition value of the essential oil was determined as 84.4%. The inhibition of violacein production by the essential oil in Chromobacterium violaceum ATCC 12472 indicated the possibility of anti-quorum sensing activity. The results of this study show that the essential oil of S. absconditiflora could be a promising alternative in fighting bacterial infections.

Anahtar Kelimeler

Antibacterial activity, antibiofilm activity, anti-quorum sensing activity, essential oil, Lamiaceae, Salvia absconditiflora

Kaynakça

1. Sofowora, A., Ogunbodede, E., Onayade, A. (2013). The role and place of medicinal plants in the strategies for disease prevention. African Journal of Traditional, Complementary and Alternative Medicines, 10(5), 210-229. [CrossRef]
2. Tako, E. (2020). Dietary plant-origin bio-active compounds, intestinal functionality, and microbiome. Nutrients, 12(11), 3223. [CrossRef]
3. Dhifi, W., Sana Bellili, S., Jazi, S., Bahloul, N., Wissem Mnif, W. (2016). Essential oils’ chemical characterization and investigation of some biological activities: A critical review. Medicines (Basel), 3(4), 25. [CrossRef]
4. Karpinski, T.M. (2020). Essential oils of Lamiaceae family plants as antifungals. Biomolecules, 10, 103. [CrossRef]
5. Standley, P., Williams, L. (1973). Labiatae. Fieldiana Botany, 24, p.237-317.
6. Davis, P.H. (1982). Flora of Turkey and the East Aegean Island. Vol. 7. Edinburgh University Press. p. 433-434.
7. Davis, P.H. (1988). Flora of Turkey and the East Aegean Island. Vol.10. Edinburgh University Press. p. 150-151.
8. Güner, A., Özhatay, N., Ekim, T., Baser, K.H.C. (2000). Flora of Turkey and the East Aegean Island. Vol. 11, Suppl. Edinburgh University Press. p. 141.
9. Abd Rashed, A., Rathi, D.N.G. (2021). Bioactive components of Salvia and their potential antidiabetic properties: A Review. Molecules, 26, 3042. [CrossRef]
10. Lopresti, A.L. (2017). Salvia (Sage): A Review of its potential cognitive-enhancing and protective effects. Drugs in R&D, 17(1), 53-64. [CrossRef]
11. Lu, Y., Foo, L.Y. (2002). Polyphenolics of Salvia-a review. Phytochemistry, 59(2), 117-40. [CrossRef]
12. Xu, J., Wei, K., Zhang, G., Lei, L., Yang, D., Wang, W., Han, Q., Xia, Y., Bi, Y., Yang, M., Yang, M., Li, M. (2018). Ethnopharmacology, phytochemistry, and pharmacology of Chinese Salvia species: A review. Journal of Ethnopharmacology, 225, 18-30. [CrossRef]
13. Tosun, A., Khan, S., Kim, Y.S., Calín-Sánchez, Á., Hysenaj, X., Carbonell-Barrachina, A. (2014). Essential oil composition and anti-inflammatory activity of Salvia officinalis L (Lamiaceae) in murin macrophages. Tropical Journal of Pharmaceutical Research, 13(6), 937-942. [CrossRef]
14. Askari, S.F., Avan, R., Tayarani-Najaran, Z., Sahebkar, A., Eghbali, S. (2021). Iranian Salvia species: A phytochemical and pharmacological update. Phytochemistry, 183, 112619. [CrossRef]
15. Onder, A., Izgi, M.N., Cinar, A.S., Zengin, G., Yilmaz, M.A. (2022) The characterization of phenolic compounds via LC-ESI-MS/MS, antioxidant, enzyme inhibitory activities of Salvia absconditiflora, Salvia sclarea, and Salvia palaestina: A comparative analysis. South African Journal of Botany, 150, 313-322. [CrossRef]
16. Bellomaria, B., Arnold, N., Valentine, G., Arnold, H.J. (1992). Contribution to the study of the essential oils from three species of Salvia growing wild in the eastern Mediterranean region. Journal of Essential Oil Research, 4, 607-614. [CrossRef]
17. Doğan, G., Hayta, Ş., Demirpolat, A., Bagci, E. (2017). Composition of the essential oil of endemic Salvia cryptantha Lamiaceae Montbret & Aucher Ex Bentham from Turkey. Hacettepe Journal of Biology and Chemistry, 45(3), 315-320. [CrossRef]
18. Kaya, A., Doğu, S., Demirci, B. (2022). Geographical impact on essential oil composition of endemic Salvia absconditiflora collected from different parts of Turkey. European Journal of Life Sciences, 1(2), 55-62. [CrossRef]
19. Demirpolat, A. (2023). Essential oil composition analysis, antimicrobial activities, and biosystematic studies on six species of Salvia. Life, 13(3), 634. [CrossRef]
20. Yilar, M., Bayar, Y., Bayar, A.A. (2020). Allelopathic and antifungal potentials of endemic Salvia absconditiflora Greuter & Burdet collected from different locations in Turkey. Allelopathy Journal, 49(2), 243-256. [CrossRef]
21. Islam, M.A., Islam, M., Hasan, R., Hossain, M.I., Nabi, A., Rahman, M., Goessens, W.H.F., Endtz, H.P., Boehm, A.B., Faruque, S.M. (2017). Environmental spread of NDM-1-producing multi-drug resistant bacteria in Dhaka, Bangladesh. Applied and Environmental Microbiology, 83. [CrossRef]
22. World Health Organization. (2017). Implementation of the global action plan on antimicrobial resistance. Erişim adresi: https://www.who.int/. Erişim tarihi: 17.05.2017.
23. Uroz, S., Dessaux, Y., Oger, P. (2009). Quorum sensing and quorum quenching: The yin and yang of bacterial communication. Chembiochem, 10(2), 205-216. [CrossRef]
24. Nithya, C., Begum, M.F., Pandian, S.K. (2010). Marine bacterial isolates inhibit biofilm formation and disrupt mature biofilms of Pseudomonas aeruginosa PAO1. Applied Microbiology and Biotechnology, 88(1), 341-358. [CrossRef]
25. Lagha, R., Ben Abdallah. F., Al-Sarhan, B.O., Al-Sodany, Y. (2019). Antibacterial and biofilm inhibitory activity of medicinal plant essential oils against Escherichia coli isolated from UTI patients. Molecules, 24(6), 1161. [CrossRef]
26. Çiçek Polat, D., Gümüşok, S., Rızvanoğlu, S.S., Eryılmaz, M. (2023). Bioactivities of Cotinus coggygria and its HPLC-DAD phenolic profiles, Plant Biosystems-An International Journal Dealing with all Aspects of Plant Biology, 157(5), 1061-1066. [CrossRef]
27. Wińska, K., Mączka, W., Łyczko, J., Grabarczyk, M., Czubaszek, A., Szumny, A. (2019). Essential oils as antimicrobial agents-myth or real alternative? Molecules, 24(11), 2130. [CrossRef]
28. McLafferty, F.W., Stauffer, D.B. (1989). The Wiley/NBS Registry of Mass Spectral Data. New York: J Wiley and Sons. p.256.
29. Hochmuth, D.H. (2008). MassFinder 4.0, Hochmuth Scientific Consulting. Hamburg, Germany. p. 1137-1144.
30. Clinical and Laboratory Standards Institute (CLSI) (2009). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. Wayne, PA, USA. p. 15-50.
31. Bali, E.B., Türkmen, K.E., Erdönmez, D., Sağlam, N. (2019). Comparative study of inhibitory potential of dietary phytochemicals against quorum sensing activity of and biofilm formation by Chromobacterium violaceum 12472, and swimming and swarming behaviour of Pseudomonas aeruginosa PAO1. Food Technology and Biotechnology, 57(2), 212-221. [CrossRef]
32. Eryılmaz, M., Kart, D., Gürpınar, S.S. (2019). Vajinal floradan izole edilen Lactobacillus sp. metabolitlerinin antibiyofilm aktivitelerinin araştırılması. Türk Mikrobiyoloji Cemiyeti Dergisi, 49(3), 169-174.
33. Jardak, M., Mnif, S., Ayed, R.B., Rezgui, F., Aifa, S. (2021). Chemical composition, antibiofilm activities of Tunisian spices essential oils, and combinatorial effect against Staphylococcus epidermidis biofilm. Lebensmittel-Wissenschaft & Technologie, 140, 110691. [CrossRef]
34. Gajdács, M., Spengler, G. (2020). Standard operating procedure (SOP) for disk diffusion-based quorum sensing inhibition assays. Acta Pharmaceutica Hungarica, 89, 117-125. [CrossRef]
35. Batohi, N., Lone, S.A., Marimani, M., Wani, M.Y., Al-Bogami, A.S., Ahmad, A. (2021). Citral, and its derivatives inhibit quorum sensing and biofilm formation in Chromobacterium violaceum. Archives of Microbiology, 203(4), 1451-1459. [CrossRef]
36. Bingöl, Ü., Cosge, B., Ipek, A., Gürbüz, B., Geven, F.G. (2009). Identification of essential oil components of Salvia cryptantha Montbret & Aucher ex Bentham, growing wild in Turkey. Asian Journal of Chemistry, 21(5), 3836-3840.
37. İpek, A., Gürbüz, B., Bingöl, M.Ü., Geven, F., Akgül, G., Afshar Pour Rezaeieh, K., Coşge, B. (2012). Comparison of essential oil components of wild and field grown Salvia cryptantha Montbert & Aucher ex Bentham, in Turkey. Turkish Journal of Agriculture and Forestry, 36, 668-672. [CrossRef]
38. Bagci, E., Vural, M., Dirmenci, T., Bruehl, L., Aitzetmüller, K. (2004). Fatty acid and tocochromanol patterns of some Salvia L. species. Zeitschrift fur Naturforschung-Section C Journal of Biosciences, 59(5-6), 305-309. [CrossRef]
39. Saadia, Z., Özcan, M.M., Bagci, Y., Ünver, A., Arslan, D., Durak, G., Er, F., Saglam, C. (2010). Chemical composition of the essential oil of Salvia cryptantha. Journal of Essential Oil Bearing Plants, 13(2), 200-204. [CrossRef]
40. Kokoska, L., Kloucek, P., Leuner, O., Novy, P. (2019). Plant-derived products as antibacterial and antifungal agents in human health care. Current Medicinal Chemistry, 26(29), 5501-5541. [CrossRef]
41. Civra, A., Francese, R., Sinato, D., Donalisio, M., Cagno, V., Rubiolo, P., Ceylan, R., Uysal, A., Zengin, G., Lembo, D. (2017). In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus. BMC Complementary Medicine and Therapies, 17(1), 74. [CrossRef]
42. Süntar, I., Akkol, E.K., Senol, F.S., Keles, H., Orhan, I.E. (2011). Investigating wound healing, tyrosinase inhibitory and antioxidant activities of the ethanol extracts of Salvia cryptantha and Salvia cyanescens using in vivo and in vitro experimental models. Journal of Ethnopharmacology, 135(1), 71-77. [CrossRef]
43. Tepe, B., Donmez, E., Unlu, M., Candan, F., Daferera, D., Vardar-Unlu, G., Polissiou, M., Sokmen, A. (2004). Antimicrobial and antioxidative activities of the essential oils and methanol extracts of Salvia cryptantha (Montbret et Aucher ex Benth.) and Salvia multicaulis (Vahl). Food Chemistry, 84, 519-525. [CrossRef]
44. Yalcin, A., Yumrutas, O., Kuloglu, T., Elibol, E., Parlar, A., Yilmaz, I., Pehlivan, M., Dogukan, M., Uckardes, F., Aydin, H., Turk, A., Uludag, O., Sahin, İ., Ugur, K., Aydin, S. (2017). Hepatoprotective properties for Salvia cryptantha extract on carbon tetrachloride-induced liver injury. Cellular and Molecular Biology (Noisy-le-grand), 63(12), 56-62. [CrossRef]
45. Zhang, H., Li, L., Hao, M., Chen, K., Lu, Y., Qi, J., Chen, W., Ren, L., Cai, X., Chen, C., Liu, Z., Zhao, B., Li, Z., Hou, P. (2021). Yixin-Fumai granules improve sick sinus syndrome in aging mice through Nrf-2/HO-1 pathway: A new target for sick sinus syndrome. Journal of Ethnopharmacology, 277, 114254. [CrossRef]
46. Mączka, W., Duda-Madej, A., Górny, A., Grabarczyk, M., Wińska, K. (2021). Can eucalyptol replace antibiotics? Molecules, 26(16), 4933. [CrossRef]
47. Cai, Z.M., Peng, J.Q., Chen, Y., Tao, L., Zhang, Y.Y., Fu, L.Y., Long, Q.D., Shen, X.C. (2021). 1,8-Cineole: A review of source, biological activities, and application. Journal of Asian Natural Products Research, 23(10), 938-954. [CrossRef]
48. Chen, W., Vermaak, I., Viljoen, A. (2013). Camphor-A fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon-A Review. Molecules, 18(5), 5434-54. [CrossRef]
49. Alain, K.Y., Tamfu, A.N., Kucukaydin, S., Ceylan, O., Pascal, A.D.C., F´elicien, A., Dominique, S.C.K., Duru, M.E., Mihaela Dinica, R.M. (2022). Phenolic profiles, antioxidant, antiquorum sensing, antibiofilm and enzyme inhibitory activities of selected Acacia species collected from Benin. LWT-Food Science and Technology, 171, 114162. [CrossRef]
50. Tamfu, A.N., Ceylan, O., Cârâc, G., Talla, E., Dinica, R.M. (2022). Antibiofilm and anti-quorum sensing potential of cycloartane-type triterpene acids from cameroonian grassland propolis: Phenolic profile and antioxidant activity of crude extract. Molecules, 27, 4872. [CrossRef]
51. Lahiri, D., Dash, S., Dutta, R., Nag, M. (2019). Elucidating the effect of anti-biofilm activity of bioactive compounds extracted from plants. Journal of Biosciences, 44(2), 52. [CrossRef]
52. Kalia, V.C. (2013). Quorum sensing inhibitors: An overview. Biotechnology Advances, 31, 224-245. [CrossRef]
53. Bhardwaj, A.K., Vinothkumar, K., Rajpara, N. (2013). Bacterial quorum sensing inhibitors: Attractive alternatives for control of infectious pathogens showing multiple drug resistance. Recent Advances in Anti-Infective Drug Discovery, 8, 68-83. [CrossRef]
54. El-Naggar, M.H., Elgaml, A., Abdel Bar, F.M., Badria, F.A. (2019). Antimicrobial and anti-quorum-sensing activity of Ricinus communis extracts and ricinine derivatives. Natural Product Research, 33(11), 1556-1562. [CrossRef]
55. White, C.E., Winans, S.C. (2007). Cell-cell communication in the plant pathogen Agrobacterium tumefaciens. Philosophical Transactions of the Royal Society B, 362, 1135-1148. [CrossRef]
56. Dickschat, J.S. (2010). Quorum sensing and bacterial biofilms. Natural Product Reports, 27, 343-369. [CrossRef]

Toplam 56 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Farmakognozi
Bölüm	Araştırma Makalesi
Yazarlar	Ahsen Sevde Çınar 0000-0001-6030-6931 Suna Sibel Rızvanoğlu 0000-0003-4244-0920 Müjde Eryılmaz 0000-0003-3760-1996 Betül Demirci 0000-0003-2343-746X Alev Önder 0000-0002-9088-1045
Erken Görünüm Tarihi	24 Nisan 2024
Yayımlanma Tarihi
Gönderilme Tarihi	9 Ocak 2024
Kabul Tarihi	27 Mart 2024
Yayımlandığı Sayı	Yıl 2024 Cilt: 48 Sayı: 2

Kaynak Göster

APA	Çınar, A. S., Rızvanoğlu, S. S., Eryılmaz, M., Demirci, B., vd. (2024). CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Journal of Faculty of Pharmacy of Ankara University, 48(2), 19-19. https://doi.org/10.33483/jfpau.1416623
AMA	Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A. CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Ankara Ecz. Fak. Derg. Nisan 2024;48(2):19-19. doi:10.33483/jfpau.1416623
Chicago	Çınar, Ahsen Sevde, Suna Sibel Rızvanoğlu, Müjde Eryılmaz, Betül Demirci, ve Alev Önder. “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”. Journal of Faculty of Pharmacy of Ankara University 48, sy. 2 (Nisan 2024): 19-19. https://doi.org/10.33483/jfpau.1416623.
EndNote	Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A (01 Nisan 2024) CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Journal of Faculty of Pharmacy of Ankara University 48 2 19–19.
IEEE	A. S. Çınar, S. S. Rızvanoğlu, M. Eryılmaz, B. Demirci, ve A. Önder, “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”, Ankara Ecz. Fak. Derg., c. 48, sy. 2, ss. 19–19, 2024, doi: 10.33483/jfpau.1416623.
ISNAD	Çınar, Ahsen Sevde vd. “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”. Journal of Faculty of Pharmacy of Ankara University 48/2 (Nisan 2024), 19-19. https://doi.org/10.33483/jfpau.1416623.
JAMA	Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A. CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Ankara Ecz. Fak. Derg. 2024;48:19–19.
MLA	Çınar, Ahsen Sevde vd. “CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET”. Journal of Faculty of Pharmacy of Ankara University, c. 48, sy. 2, 2024, ss. 19-19, doi:10.33483/jfpau.1416623.
Vancouver	Çınar AS, Rızvanoğlu SS, Eryılmaz M, Demirci B, Önder A. CHEMICAL COMPOSITION AND BIOACTIVITIES OF ESSENTIAL OIL FROM AN ENDEMIC SALVIA ABSCONDITIFLORA GREUTER & BURDET. Ankara Ecz. Fak. Derg. 2024;48(2):19-.

Kapak Resmi İndir

Makale Dosyaları

Tam Metin

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.