Yara Giysisi İçin Potansiyel Bir Bitki: Polygonum Cognatum Meissn.'in Farmakolojik Aktivitelerinin 3B Hücre Kültürü Perspektifiyle Değerlendirilmesi
Öz
Fizyolojik yara iyileşmesi, hemostaz/iltihap fazı, proliferasyon fazı ve yeniden şekillenme fazı tarafından düzenlenen karmaşık, çok yönlü bir süreçtir. Yara iyileşme mekanizmasının daha iyi anlaşılabilmesi için literatürde in vitro ve in vivo yara modelleri ile ilgili yeni raporlar yayımlanmaktadır. Otoimmün, diyabetik, bası ve yanık yaralarında doku onarımı yetersiz ilerleyebilmektedir. Bu bakımdan bu tür yaraları olan hastaların hücresel terapi ile tedavi edilmesi gerekebilmektedir. Rejeneratif tıp, hastalıklı ve yaralı dokuları iyileştirmek ve onarmak, normal işlevi eski haline getirmek ve sürdürmek için yaşam bilimlerine mühendislik ilkelerinin uygulandığı disiplinler arası bir çalışma alanıdır. Polygonum cognatum Meissn. (P. cognatum), ham protein, vitamin C, E, karotenoidler, Zn, Fe ve Mn elementleri, folik asit düzeyleri açısından zengin, antioksidan, antimikrobiyal, idrar söktürücü, antidiyabetik, antelmintik ve antifungal özelliklere sahip Polygonaceae familyasına ait çok yıllık yabani yenilebilir bir bitki türüdür. Bu derlemede, P. cognatum'un farmakolojik özelliklerini ve 3 boyutlu yapı iskelelerine aday olarak kullanımını incelemeyi amaçladık. “Polygonum Cognatum” anahtar kelimesi için PubMed ve Google Scholar veri tabanından literatür taraması yapılmış ve 15 makale tespit edilmiştir. Hücresizleştirme yoluyla bir 3D doku iskelesi olarak P. cognatum yaprakları, cilt yara örtüsü olarak özgün bir yaklaşım sunabilir.
Anahtar Kelimeler
Polygonum Cognatum Meissn. Yara İyileşmesi İnflamasyon 3B Doku İskelesi
Kaynakça
- 1. Lindley LE, Stojadinovic O, Pastar I and Tomic-Canic M. Biology and biomarkers for wound healing, Plast Reconstr Surg. 2010; 138(Suppl. 3):18Se28S.
- 2. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, and Jeschke MG. Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies, Mol Med. 2011;17:113-25.
- 3. Berman B, Maderal A, and Raphael B. Keloids and hypertrophic scars: Pathophysiology, classification and treatment. Dermatol Surg. 2017;43(Suppl. 1):Se18.
- 4. Su WH, Cheng MH, Lee WL, Tsou, TS, Chang WH, and Chen CS. Nonsteroidal anti-inflammatory drugs for wounds: Pain relief or excessive scar formation? Mediat Inflamm. 2010;2010:413238.
- 5. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, and Zheng Y. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2010;355:748-52.
- 6. Tsai HW, Wang PH, and Tsui KH. Mesenchymal stem cell in wound healing and regeneration. J Chin Med Assoc. 2018;81:223-4
- 7. Yannas IV, Tzeranis DS, So PTC. Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation. Wound Repair Regen. 2017;25:177-91.
- 8. Larson BJ, Longaker MT, Lorenz HP. Scarless fetal wound healing: A basic science review. Plast Reconstr Surg. 2010;126:1172-80.
- 9. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017;18:e606.
- 10. Huang C, Akaishi S, Hyakusoku H, Ogawa R. Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings. Int Wound J. 2014;11:517-22.
- 11. Cohen BE, Geronemus RG, McDaniel DH, Brauer JA. The role of elastic fibers in scar formation and treatment. Dermatol Surg. 2017;43(Suppl.1):S19-24.
- 12. De Leon AC, Chen Q, Palaganas N, Palaganas JO, Manapat J, and Advincula RC. High performance polymer nanocomposites for additive manufacturing applications. React Funct Polym. 2016;103:141-55.
- 13. Alam F, Shukla VR, Varadarajan KM, and Kumar S. Microarchitected polylactic acid (PLA) nanocomposite scaffolds for biomedical applications. J Mech Behav Biomed Mater. 2020;103:1035-76.
- 14. Yidirim A, Mavi A, Kara AA. Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts. J Sci Food Agric. 2003;83:64–9.
- 15. Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elâzığ-Turkey). J Ethnopharmacol. 2010;132:165–75.
- 16. Onen H, Yilar M, Kaya C. Phenoleic composition of madimak (polygonum cognatum meissn.) Plants, 3rd Plant Protection Congress, Van, Turkey, 2009 Abstract Book Page 275.
- 17. Eruygur N, Ucar E, Atas M, Ergul M, Sozmen F. Determination of biological activity of Tragopogonporrifolius and Polygonum cognatum consumed intensively by people in Sivas. ToxicolRep. 2019;7:59-66.
- 18. Guragac Dereli FT, Ilhan M, Kozan E, Kupeli Akkol E. Effective eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) with Polygonum cognatum Meissn. Exp Parasitol. 2019;196:63-7.
- 19. Hussain F, Ahmad B, Hameed I, Dastagir G, Sanaullah P, Azam S. Antibacterial, antifungal and insecticidal activities of some selected medicinal plants of Polygonaceae. Afr J Biotechnol. 2010;9:5032–6.
- 20. Pekdemir ME, Pekdemir S, İnci S, Kirbag S, Ciftci M. Thermal, Magnetic Properties and Antimicrobial Effects of Magnetic Iron Oxide Nanoparticles Treated with Polygonum cognatum. Iran J SciTechnol Trans Sci. 2021;45:1579–86.
- 21. Yilmaz HS, Kaplan M, Kokten K. Determination of The Nutritive Value of Some Weed Species. Türk Tarım ve Doğa Bilimleri Dergisi. 2015;2:320–3.
- 22. Pekdemir, S, Ciftci M, Karatepe M. Elazığ’da Yetişen Polygonum cognatum Meissn (Madımak) Bitki Ekstraktlarının In vitro Biyolojik Aktiviteleri ve Bazı Fitokimyasal Bileşenlerinin Belirlenmesi. European Journal of Science and Technology. 2020;18:368-78.
- 23. Ulusoy H, Acidereli H, Tutar U. Optimization of Extraction Parameters for Fat-Soluble Vitamins and Major Element Analysis in Polygonum cognatum Meissn Plant (Madımak). JOTCSA. 2017;4:165–78.
- 24. Ulusoy S, Erdogan S, Karaslan MG, Ates B, Ulusoy HI, Erdemoglu, S. Optimization of Extraction Parameters For Folic Acid And Antioxidant Compounds From An Edible Plant (Polygonum cognatum Meissn) Using Pressurized Liquid Extraction (PLE) System. Cumhuriyet Science Journal. 2020;39:1069-80.
- 25. Yildirim BA, Kordali S, Yildirim S, Yildirim F. Protective Effect of Polygonum Cognatum Meissn Ethanolic Extract on Experimental Hemorrhoids in Rats. Int J Current Res. 2017;9:46213-18.
- 26. Cevik O, Sener A, Ozdemir ZK, Cetinel S, Altintas A, Oba R, et al. Protective and Therapeutic Effects of Polygonum cognatum Meissn AqueousExtract in ExperimentalColitis. Marmara Pharmaceutical J. 2014;18:126-34.
- 27. Pehlivan M, Karahan Coven Hİ, Cerci B, Eldem A, Oz T, Savlak N, et al. The Cytotoxic Effect of Polygonium cognatum and Chemotherapeutic Effect of Doxorubicin on Glioblastoma Cells. Eur J Ther. 2021;27:50-4.
- 28. Sarac H, Dastan T, Demirbas A, Durna Dastan S, Karakoy T, Durukan H. Madımak (Polygonum cognatum Meissn.) Bitki Özütlerinin Besin Elementleri ve In Vitro Antikanserojen Aktiviteleri Yönünden Değerlendirilmesi. Ziraat Fakültesi Dergisi. 2018;1. Uluslararası Tarımsal Yapılar ve Sulama Kongresi Özel Sayısı:340-7.
- 29. Mahendiran B, Muthusamy S, Selvakumar R, Rajeswaran N, Sampath S, Jaisankar SN, et al. Decellularized natural 3D Cellulose Scaffold Derived from Borassus Flabellifer (Linn.) As Extracellular Matrix For Tissue Engineering Applications. Carbohydr Polym. 2021;272:118494.
- 30. Cheng YW, Shiwarski DJ, Ball RL, Whitehead KA, Feinberg AW. Engineering Aligned Skeletal Muscle Tissue Using Decellularized Plant-Derived Scaffolds. ACS Biomaterials Science and Engineering. 2020;6:3046-54.
- 31. Li Q, Niu Y, Xing P and Wang C. Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair. Chin Med. 2018;13:1–11.
- 32. Gershlak JR, Hernandez S, Fontana G, Perreault LR, Hansen K J, Larson SA, et al. Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials. 2017;125:13−22.
A Potential Plant for Wound Dressing: Evaluation of the Pharmacological Activities of Polygonum Cognatum Meissn with a 3D Cell Culture Perspective
Öz
A physiologic wound healing is a complex multi-faceted process regulated by the hemostasis/inflammation, proliferation, and remodelling phases. In order to better understand the wound healing mechanism, novel reports are published in the literature with in vitro and in vivo wound models. Tissue repair may progress insufficiently in autoimmune, diabetic, pressure and burn wounds. In this regard, patients with like these wounds may need to be treated with cellular therapy. Regenerative medicine is an interdisciplinary field of study in which life sciences apply engineering principles to heal and repair diseased and injured tissues and restore and maintain normal function. Polygonum cognatum Meissn (P. cognatum) is an antioxidant and antimicrobial perennial wild edible plant belonging to the Polygonaceae family that is rich in crude protein, vitamin C and E, carotenoids, Zn, Fe and, Mn elements, folic acid. In this review, we aimed to summarize the pharmacological properties of P. cognatum and its potential use as a candidate for 3D scaffolds. The literature search from the database PubMed and Google Scholar was done for the keyword “Polygonum Cognatum” and 15 articles were identified. P. cognatum leaves as a 3D tissue scaffold by decellularization may present a unique approach as a skin wound dressing.
Anahtar Kelimeler
Polygonum Cognatum Meissn. Wound Healing Inflammation 3D Tissue Scaffold
Kaynakça
- 1. Lindley LE, Stojadinovic O, Pastar I and Tomic-Canic M. Biology and biomarkers for wound healing, Plast Reconstr Surg. 2010; 138(Suppl. 3):18Se28S.
- 2. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, and Jeschke MG. Hypertrophic scarring and keloids: Pathomechanisms and current and emerging treatment strategies, Mol Med. 2011;17:113-25.
- 3. Berman B, Maderal A, and Raphael B. Keloids and hypertrophic scars: Pathophysiology, classification and treatment. Dermatol Surg. 2017;43(Suppl. 1):Se18.
- 4. Su WH, Cheng MH, Lee WL, Tsou, TS, Chang WH, and Chen CS. Nonsteroidal anti-inflammatory drugs for wounds: Pain relief or excessive scar formation? Mediat Inflamm. 2010;2010:413238.
- 5. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, and Zheng Y. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2010;355:748-52.
- 6. Tsai HW, Wang PH, and Tsui KH. Mesenchymal stem cell in wound healing and regeneration. J Chin Med Assoc. 2018;81:223-4
- 7. Yannas IV, Tzeranis DS, So PTC. Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation. Wound Repair Regen. 2017;25:177-91.
- 8. Larson BJ, Longaker MT, Lorenz HP. Scarless fetal wound healing: A basic science review. Plast Reconstr Surg. 2010;126:1172-80.
- 9. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017;18:e606.
- 10. Huang C, Akaishi S, Hyakusoku H, Ogawa R. Are keloid and hypertrophic scar different forms of the same disorder? A fibroproliferative skin disorder hypothesis based on keloid findings. Int Wound J. 2014;11:517-22.
- 11. Cohen BE, Geronemus RG, McDaniel DH, Brauer JA. The role of elastic fibers in scar formation and treatment. Dermatol Surg. 2017;43(Suppl.1):S19-24.
- 12. De Leon AC, Chen Q, Palaganas N, Palaganas JO, Manapat J, and Advincula RC. High performance polymer nanocomposites for additive manufacturing applications. React Funct Polym. 2016;103:141-55.
- 13. Alam F, Shukla VR, Varadarajan KM, and Kumar S. Microarchitected polylactic acid (PLA) nanocomposite scaffolds for biomedical applications. J Mech Behav Biomed Mater. 2020;103:1035-76.
- 14. Yidirim A, Mavi A, Kara AA. Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts. J Sci Food Agric. 2003;83:64–9.
- 15. Cakilcioglu U, Turkoglu I. An ethnobotanical survey of medicinal plants in Sivrice (Elâzığ-Turkey). J Ethnopharmacol. 2010;132:165–75.
- 16. Onen H, Yilar M, Kaya C. Phenoleic composition of madimak (polygonum cognatum meissn.) Plants, 3rd Plant Protection Congress, Van, Turkey, 2009 Abstract Book Page 275.
- 17. Eruygur N, Ucar E, Atas M, Ergul M, Sozmen F. Determination of biological activity of Tragopogonporrifolius and Polygonum cognatum consumed intensively by people in Sivas. ToxicolRep. 2019;7:59-66.
- 18. Guragac Dereli FT, Ilhan M, Kozan E, Kupeli Akkol E. Effective eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) with Polygonum cognatum Meissn. Exp Parasitol. 2019;196:63-7.
- 19. Hussain F, Ahmad B, Hameed I, Dastagir G, Sanaullah P, Azam S. Antibacterial, antifungal and insecticidal activities of some selected medicinal plants of Polygonaceae. Afr J Biotechnol. 2010;9:5032–6.
- 20. Pekdemir ME, Pekdemir S, İnci S, Kirbag S, Ciftci M. Thermal, Magnetic Properties and Antimicrobial Effects of Magnetic Iron Oxide Nanoparticles Treated with Polygonum cognatum. Iran J SciTechnol Trans Sci. 2021;45:1579–86.
- 21. Yilmaz HS, Kaplan M, Kokten K. Determination of The Nutritive Value of Some Weed Species. Türk Tarım ve Doğa Bilimleri Dergisi. 2015;2:320–3.
- 22. Pekdemir, S, Ciftci M, Karatepe M. Elazığ’da Yetişen Polygonum cognatum Meissn (Madımak) Bitki Ekstraktlarının In vitro Biyolojik Aktiviteleri ve Bazı Fitokimyasal Bileşenlerinin Belirlenmesi. European Journal of Science and Technology. 2020;18:368-78.
- 23. Ulusoy H, Acidereli H, Tutar U. Optimization of Extraction Parameters for Fat-Soluble Vitamins and Major Element Analysis in Polygonum cognatum Meissn Plant (Madımak). JOTCSA. 2017;4:165–78.
- 24. Ulusoy S, Erdogan S, Karaslan MG, Ates B, Ulusoy HI, Erdemoglu, S. Optimization of Extraction Parameters For Folic Acid And Antioxidant Compounds From An Edible Plant (Polygonum cognatum Meissn) Using Pressurized Liquid Extraction (PLE) System. Cumhuriyet Science Journal. 2020;39:1069-80.
- 25. Yildirim BA, Kordali S, Yildirim S, Yildirim F. Protective Effect of Polygonum Cognatum Meissn Ethanolic Extract on Experimental Hemorrhoids in Rats. Int J Current Res. 2017;9:46213-18.
- 26. Cevik O, Sener A, Ozdemir ZK, Cetinel S, Altintas A, Oba R, et al. Protective and Therapeutic Effects of Polygonum cognatum Meissn AqueousExtract in ExperimentalColitis. Marmara Pharmaceutical J. 2014;18:126-34.
- 27. Pehlivan M, Karahan Coven Hİ, Cerci B, Eldem A, Oz T, Savlak N, et al. The Cytotoxic Effect of Polygonium cognatum and Chemotherapeutic Effect of Doxorubicin on Glioblastoma Cells. Eur J Ther. 2021;27:50-4.
- 28. Sarac H, Dastan T, Demirbas A, Durna Dastan S, Karakoy T, Durukan H. Madımak (Polygonum cognatum Meissn.) Bitki Özütlerinin Besin Elementleri ve In Vitro Antikanserojen Aktiviteleri Yönünden Değerlendirilmesi. Ziraat Fakültesi Dergisi. 2018;1. Uluslararası Tarımsal Yapılar ve Sulama Kongresi Özel Sayısı:340-7.
- 29. Mahendiran B, Muthusamy S, Selvakumar R, Rajeswaran N, Sampath S, Jaisankar SN, et al. Decellularized natural 3D Cellulose Scaffold Derived from Borassus Flabellifer (Linn.) As Extracellular Matrix For Tissue Engineering Applications. Carbohydr Polym. 2021;272:118494.
- 30. Cheng YW, Shiwarski DJ, Ball RL, Whitehead KA, Feinberg AW. Engineering Aligned Skeletal Muscle Tissue Using Decellularized Plant-Derived Scaffolds. ACS Biomaterials Science and Engineering. 2020;6:3046-54.
- 31. Li Q, Niu Y, Xing P and Wang C. Bioactive polysaccharides from natural resources including Chinese medicinal herbs on tissue repair. Chin Med. 2018;13:1–11.
- 32. Gershlak JR, Hernandez S, Fontana G, Perreault LR, Hansen K J, Larson SA, et al. Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials. 2017;125:13−22.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Derlemeler |
| Yazarlar | |
| Erken Görünüm Tarihi | 3 Nisan 2023 |
| Yayımlanma Tarihi | 30 Haziran 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 1 Sayı: 2 |