Araştırma Makalesi
Yıl 2018,
Cilt: 1 Sayı: 2, 24 - 31, 25.12.2018
Öz
Kaynakça
- Asar, M., Kayisli, Ü. A., Izgüt-Uysal, V. N., & Akkoyunlu, G. (2004). Immunohistochemical and ultrastructural changes in the renal cortex of cadmium-treated rats. Biological trace element research, 97(3), 249-263.
- Barborik, M., & Dusek, J. (1972). Cardiomyopathy accompaning industrial cobalt exposure. British Heart Journal, 34(1), 113.
- Beytut, E. (2002). Erythrocyte antioxidants and plasma lipid peroxidation of rabbits exposed to cadmium. Indian veterinary journal, 79(4), 334-338.
- Bucher, J. R., Hailey, J. R., Roycroft, J. R., Haseman, J. K., Sills, R. C., Grumbein, S. L., ... & Chou, B. J. (1999). Inhalation toxicity and carcinogenicity studies of cobalt sulfate. Toxicological sciences: an official journal of the Society of Toxicology, 49(1), 56-67.
- Christova, T. Y., Duridanova, D. B., & Setchenska, M. S. (2002). Enhanced heme oxygenase activity increases the antioxidant defense capacity of guinea pig liver upon acute cobalt chloride loading: comparison with rat liver. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 131(2), 177-184.
- Christova, T. Y., Gorneva, G. A., Taxirov, S. I., Duridanova, D. B., & Setchenska, M. S. (2003). Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma-bearing mice: protective role of heme oxygenase. Toxicology letters, 138(3), 235-242.
- Ewing, J. F., & Maines, M. D. (1993). Glutathione depletion induces heme oxygenase‐1 (HSP32) mRNA and protein in rat brain. Journal of neurochemistry, 60(4), 1512-1519.
- Gonzales, S., Polizio, A. H., Erario, M. A., & Tomaro, M. L. (2005). Glutamine is highly effective in preventing in vivo cobalt-induced oxidative stress in rat liver. World Journal of Gastroenterology: WJG, 11(23), 3533.
- Hanafy, S., & Soltan, M. E. (2004). Effects of Vitamin E pretreatment on subacute toxicity of mixture of Co, Pb, and Hg nitrate-induced nephrotoxicity in rats. Environmental toxicology and pharmacology, 17(3), 159-167.
- Horowitz, S. F., Fischbein, A., Matza, D., Rizzo, J. N., Stern, A., Machac, J., & Solomon, S. J. (1988). Evaluation of right and left ventricular function in hard metal workers. Occupational and Environmental Medicine, 45(11), 742-746.
- Jonker, D., Kuper, C. F., Fraile, N., Estrella, A., & Otero, C. R. (2003). Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regulatory Toxicology and Pharmacology, 37(3), 396-406.
- Kasprzak, K. S., Zastawny, T. H., North, S. L., Riggs, C. W., Diwan, B. A., Rice, J. M., & Dizdaroglu, M. (1994). Oxidative DNA base damage in renal, hepatic, and pulmonary chromatin of rats after intraperitoneal injection of cobalt (II) acetate. Chemical research in toxicology, 7(3), 329-335.
- Kaya, S., Pirinççi, İ., & Bilgili, A. (1998). Çevre Bilimi ve Çevre Toksikolojisi. Medisan Yayın Serisi. Yayın, (36).
- Kayden, H. J., Chow, C. K., & Bjornson, L. K. (1973). Spectrophotometric method for determination of tocopherol in red blood cells. Journal of lipid research, 14(5), 533-540.
- Kerfoot, E. J., Fredrıck, W. G., & Domeıer, E. (1975). Cobalt metal inhalation studies on miniature swine. American Industrial Hygiene Association Journal, 36(1), 17-25.
- Levy, J., Bosin, E., Feldman, B., Giat, Y., Miinster, A., Danilenko, M., & Sharoni, Y. (1995). Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene.
- Nackerdien, Z., Kasprzak, K. S., Rao, G., Halliwell, B., & Dizdaroglu, M. (1991). Nickel (II)-and cobalt (II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin. Cancer research, 51(21), 5837-5842.
- National Toxicology Program. (1991). Toxicity Studies of Cobalt Sulfate Heptahydrate (CAS No. 10026-24-1) in F344/N Rats and B6C3F Mice (Inhalation Studies). Toxicity 1 Report Series No. 5. NIH Publication No. 91-3124. US Department of Health and Human Services. Public Health Service, National Institutes of Health, Research Triangle Park, NC.
- Olivieri, G., Hess, C., Savaskan, E., Ly, C., Meier, F., Baysang, G., ... & Müller‐Spahn, F. (2001). Melatonin protects SHSY5Y neuroblastoma cells from cobalt‐induced oxidative stress, neurotoxicity and increased β‐amyloid secretion. Journal of pineal research, 31(4), 320-325.
- Osinsky, S., Levitin, I., Bubnovskaya, L., Sigan, A., Ganusevich, I., Kovelskaya, A., ... & Wardman, P. (2004). Selectivity of effects of redox-active cobalt (III) complexes on tumor tissue. Exp Oncol, 26(2), 140-144.
- Placer, Z. A., Cushman, L. L., & Johnson, B. C. (1966). Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Analytical biochemistry, 16(2), 359-364.
- Rao, A. V., & Agarwal, S. (1999). Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutrition research, 19(2), 305-323.
- Sedlak, J., & Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical biochemistry, 25, 192-205.
- Shrivastava, K., Shukla, D., Bansal, A., Sairam, M., Banerjee, P. K., & Ilavazhagan, G. (2008). Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress. Neurochemistry international, 52(3), 368-375.
- Singh, P. P., & Junnarkar, A. Y. (1991). Behavioural and toxic profile of some essential trace metal salts in mice and rats. Indian Journal of Pharmacology, 23(3), 153.
- Van den Broeke, L. T., Gräslund, A., Nilsson, J. L. G., Wahlberg, J. E., Scheynius, A., & Karlberg, A. T. (1998). Free radicals as potential mediators of metal-allergy: Ni2+-and Co2+-mediated free radical generation. European journal of pharmaceutical sciences, 6(4), 279-286.Yiin, S. J., Chern, C. L., Sheu, J. Y., Tseng, W. C., & Lin, T. H. (1999). Cadmium-induced renal lipid peroxidation in rats and protection by selenium. Journal of Toxicology and Environmental Health Part A, 57(6), 403-413.
The Protective Role of Lycopene Against Oxidative Damage in the Liver, Heart and Kidney Tissues of Mice Exposed to CoCL2
Öz
Heavy metals are harmful to
both the environment and human health. One of these heavy metals is cobalt.
Lycopene is a potent antioxidant. The purpose of this study was to investigate the
effects of lycopene on change of lipid peroxidation in liver, kidney and heart
of experimentally exposed mice with cobalt (Co). Experimental protocol: For
this purpose, 30 Swiss Albino male mice of 3-4 months of age and weight ranging
from 45 to 50 g were used. Mice were subdivided in to 3 groups including
control, cobalt and cobalt lycopene (combined). The control group mice were
given 3 mg/kg/day saline (by intramuscular injection) and 10 mg/kg/day saline
(orally) for 30 days in order to achieve equality with administration to the
mice in the experimental group). At the end of this process, malondialdehit
(MDA), glutathione (GSH), vitamin-E and β -carotene were analyzed in the
prepared homogenates. According to findings;
Increase in liver MDA levels in cobalt group was significant (p <0.01).
Additionally, it was found out that cobalt toxicities increased the
level of MDA in the heart most (p<0,001). The level of GSH in the tissue of
liver, kidney and heart of the cobalt group were lower than control and combined group (p<0,001). However, the kidney and the liver vitamin E
level of the both control and combined group were very lower according to
control group (p<0,001), but not important in liver (p>0.05). It
was observed that liver and kidney β-carotene level in cobalt group was lower
than control and combined group. This decrease is statistically significant in
the kidney (p<0.05), but this decrease is statistically insignificant in the
liver (p>0.05). As a result, increasing the antioxidant levels of GSH,
vitamin E and β-carotene together with lycopene application may play an
important role in preventing the negative effects of lycopene on free radicals
(MDA, etc.) caused by acute cobalt oxidation
both the environment and human health. One of these heavy metals is cobalt.
Lycopene is a potent antioxidant. The purpose of this study was to investigate the
effects of lycopene on change of lipid peroxidation in liver, kidney and heart
of experimentally exposed mice with cobalt (Co). Experimental protocol: For
this purpose, 30 Swiss Albino male mice of 3-4 months of age and weight ranging
from 45 to 50 g were used. Mice were subdivided in to 3 groups including
control, cobalt and cobalt lycopene (combined). The control group mice were
given 3 mg/kg/day saline (by intramuscular injection) and 10 mg/kg/day saline
(orally) for 30 days in order to achieve equality with administration to the
mice in the experimental group). At the end of this process, malondialdehit
(MDA), glutathione (GSH), vitamin-E and β -carotene were analyzed in the
prepared homogenates. According to findings;
Increase in liver MDA levels in cobalt group was significant (p <0.01).
Additionally, it was found out that cobalt toxicities increased the
level of MDA in the heart most (p<0,001). The level of GSH in the tissue of
liver, kidney and heart of the cobalt group were lower than control and combined group (p<0,001). However, the kidney and the liver vitamin E
level of the both control and combined group were very lower according to
control group (p<0,001), but not important in liver (p>0.05). It
was observed that liver and kidney β-carotene level in cobalt group was lower
than control and combined group. This decrease is statistically significant in
the kidney (p<0.05), but this decrease is statistically insignificant in the
liver (p>0.05). As a result, increasing the antioxidant levels of GSH,
vitamin E and β-carotene together with lycopene application may play an
important role in preventing the negative effects of lycopene on free radicals
(MDA, etc.) caused by acute cobalt oxidation
Anahtar Kelimeler
Kaynakça
- Asar, M., Kayisli, Ü. A., Izgüt-Uysal, V. N., & Akkoyunlu, G. (2004). Immunohistochemical and ultrastructural changes in the renal cortex of cadmium-treated rats. Biological trace element research, 97(3), 249-263.
- Barborik, M., & Dusek, J. (1972). Cardiomyopathy accompaning industrial cobalt exposure. British Heart Journal, 34(1), 113.
- Beytut, E. (2002). Erythrocyte antioxidants and plasma lipid peroxidation of rabbits exposed to cadmium. Indian veterinary journal, 79(4), 334-338.
- Bucher, J. R., Hailey, J. R., Roycroft, J. R., Haseman, J. K., Sills, R. C., Grumbein, S. L., ... & Chou, B. J. (1999). Inhalation toxicity and carcinogenicity studies of cobalt sulfate. Toxicological sciences: an official journal of the Society of Toxicology, 49(1), 56-67.
- Christova, T. Y., Duridanova, D. B., & Setchenska, M. S. (2002). Enhanced heme oxygenase activity increases the antioxidant defense capacity of guinea pig liver upon acute cobalt chloride loading: comparison with rat liver. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 131(2), 177-184.
- Christova, T. Y., Gorneva, G. A., Taxirov, S. I., Duridanova, D. B., & Setchenska, M. S. (2003). Effect of cisplatin and cobalt chloride on antioxidant enzymes in the livers of Lewis lung carcinoma-bearing mice: protective role of heme oxygenase. Toxicology letters, 138(3), 235-242.
- Ewing, J. F., & Maines, M. D. (1993). Glutathione depletion induces heme oxygenase‐1 (HSP32) mRNA and protein in rat brain. Journal of neurochemistry, 60(4), 1512-1519.
- Gonzales, S., Polizio, A. H., Erario, M. A., & Tomaro, M. L. (2005). Glutamine is highly effective in preventing in vivo cobalt-induced oxidative stress in rat liver. World Journal of Gastroenterology: WJG, 11(23), 3533.
- Hanafy, S., & Soltan, M. E. (2004). Effects of Vitamin E pretreatment on subacute toxicity of mixture of Co, Pb, and Hg nitrate-induced nephrotoxicity in rats. Environmental toxicology and pharmacology, 17(3), 159-167.
- Horowitz, S. F., Fischbein, A., Matza, D., Rizzo, J. N., Stern, A., Machac, J., & Solomon, S. J. (1988). Evaluation of right and left ventricular function in hard metal workers. Occupational and Environmental Medicine, 45(11), 742-746.
- Jonker, D., Kuper, C. F., Fraile, N., Estrella, A., & Otero, C. R. (2003). Ninety-day oral toxicity study of lycopene from Blakeslea trispora in rats. Regulatory Toxicology and Pharmacology, 37(3), 396-406.
- Kasprzak, K. S., Zastawny, T. H., North, S. L., Riggs, C. W., Diwan, B. A., Rice, J. M., & Dizdaroglu, M. (1994). Oxidative DNA base damage in renal, hepatic, and pulmonary chromatin of rats after intraperitoneal injection of cobalt (II) acetate. Chemical research in toxicology, 7(3), 329-335.
- Kaya, S., Pirinççi, İ., & Bilgili, A. (1998). Çevre Bilimi ve Çevre Toksikolojisi. Medisan Yayın Serisi. Yayın, (36).
- Kayden, H. J., Chow, C. K., & Bjornson, L. K. (1973). Spectrophotometric method for determination of tocopherol in red blood cells. Journal of lipid research, 14(5), 533-540.
- Kerfoot, E. J., Fredrıck, W. G., & Domeıer, E. (1975). Cobalt metal inhalation studies on miniature swine. American Industrial Hygiene Association Journal, 36(1), 17-25.
- Levy, J., Bosin, E., Feldman, B., Giat, Y., Miinster, A., Danilenko, M., & Sharoni, Y. (1995). Lycopene is a more potent inhibitor of human cancer cell proliferation than either α‐carotene or β‐carotene.
- Nackerdien, Z., Kasprzak, K. S., Rao, G., Halliwell, B., & Dizdaroglu, M. (1991). Nickel (II)-and cobalt (II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin. Cancer research, 51(21), 5837-5842.
- National Toxicology Program. (1991). Toxicity Studies of Cobalt Sulfate Heptahydrate (CAS No. 10026-24-1) in F344/N Rats and B6C3F Mice (Inhalation Studies). Toxicity 1 Report Series No. 5. NIH Publication No. 91-3124. US Department of Health and Human Services. Public Health Service, National Institutes of Health, Research Triangle Park, NC.
- Olivieri, G., Hess, C., Savaskan, E., Ly, C., Meier, F., Baysang, G., ... & Müller‐Spahn, F. (2001). Melatonin protects SHSY5Y neuroblastoma cells from cobalt‐induced oxidative stress, neurotoxicity and increased β‐amyloid secretion. Journal of pineal research, 31(4), 320-325.
- Osinsky, S., Levitin, I., Bubnovskaya, L., Sigan, A., Ganusevich, I., Kovelskaya, A., ... & Wardman, P. (2004). Selectivity of effects of redox-active cobalt (III) complexes on tumor tissue. Exp Oncol, 26(2), 140-144.
- Placer, Z. A., Cushman, L. L., & Johnson, B. C. (1966). Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Analytical biochemistry, 16(2), 359-364.
- Rao, A. V., & Agarwal, S. (1999). Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutrition research, 19(2), 305-323.
- Sedlak, J., & Lindsay, R. H. (1968). Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Analytical biochemistry, 25, 192-205.
- Shrivastava, K., Shukla, D., Bansal, A., Sairam, M., Banerjee, P. K., & Ilavazhagan, G. (2008). Neuroprotective effect of cobalt chloride on hypobaric hypoxia-induced oxidative stress. Neurochemistry international, 52(3), 368-375.
- Singh, P. P., & Junnarkar, A. Y. (1991). Behavioural and toxic profile of some essential trace metal salts in mice and rats. Indian Journal of Pharmacology, 23(3), 153.
- Van den Broeke, L. T., Gräslund, A., Nilsson, J. L. G., Wahlberg, J. E., Scheynius, A., & Karlberg, A. T. (1998). Free radicals as potential mediators of metal-allergy: Ni2+-and Co2+-mediated free radical generation. European journal of pharmaceutical sciences, 6(4), 279-286.Yiin, S. J., Chern, C. L., Sheu, J. Y., Tseng, W. C., & Lin, T. H. (1999). Cadmium-induced renal lipid peroxidation in rats and protection by selenium. Journal of Toxicology and Environmental Health Part A, 57(6), 403-413.
Toplam 26 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Spor Hekimliği |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 25 Aralık 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 1 Sayı: 2 |
