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Evaluation of pH and Calcium Ion Diffusion from Intracanal MTA and Bioaggregate to Simulated External Resorption Cavities Through Dentinal Tubules

Yıl 2022, Cilt: 49 Sayı: 3, 108 - 114, 31.12.2022
https://doi.org/10.52037/eads.2022.0035

Öz

Purpose: This in vitro study compared the effects of mineral trioxide aggregate (MTA), BioAggregate and calcium hydroxide on calcium and hydroxyl ion diffusion through dentinal tubules to the root surfaces without cementum in various root levels.
Materials & Methods: The study consisted of 120 mature single-rooted mandibular premolar teeth. The teeth were decoronated and instrumented using Protaper Universal rotary files. To simulate external root resorption, artificial defects were created in cervical-middle-apical thirds of root surfaces. The teeth were divided into four main groups: Control (1), calcium hydroxide (2), MTA (3) and BioAggregate (4). In control group, root canals of specimens left empty. Other root canals of specimens filled with calcium hydroxide, MTA or BioAggregate. Each specimen was immersed in a vial containing 10 mL distilled water. Calcium concentrations and pH of the immersion media was measured at 1, 3, 7, 14, 21 and 28 days. Statistical analysis was accomplished by Kruskal–Wallis H and Mann–Whitney-U tests.
Results: This study indicated that intracanal placement of both calcium hydroxide, MTA and BioAggregate resulted in the diffusion of calcium and hydroxyl ions across dentine. The results showed greater calcium and hydroxyl ions released by calcium hydroxide groups than MTA and BioAggregate groups (p<0.05). MTA and BioAggregate groups showed similar properties and there were no differences between these groups in whole study period (p>0.05).
Conclusion: MTA and BioAggregate may be preferable for external root resorption cases because of their stimulation of hard tissue formation and ion releasing ability.

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • 1. Abbott PV, Lin S. Tooth resorption-Part 2: A clinical classification. Dent Traumatol. 2022 Aug 38(4):267-85. doi:10.1111/edt.12762.
  • 2. Abbott PV. Prevention and management of external inflammatory resorption following trauma to teeth. Aust Dent J. 2016 Mar 61 Suppl 1:82-94. doi:10.1111/adj.12400.
  • 3. Ozdemir HO, Ozçelik B, Karabucak B, Cehreli ZC. Calcium ion diffusion from mineral trioxide aggregate through simulated root resorption defects. Dent Traumatol. 2008 Feb 24(1):70-3. doi:10.1111/j.1600-9657.2006.00512.x.
  • 4. Angkasuvan V, Panichuttra A, Nawachinda M, Ratisoontorn C. Evaluation of pH and calcium ion release at the simulated external root resorption cavities of teeth obturated with bioceramic sealer. Clin Exp Dent Res. 2022 Aug 8(4):900-5. doi: 10.1002/cre2.573.
  • 5. Trope M, Moshonov J, Nissan R, Buxt P, Yesilsoy C. Short vs. long-term calcium hydroxide treatment of established inflammatory root resorption in replanted dog teeth. Endod Dent Traumatol. 1995 Jun 11(3):124-8. doi:10.1111/j.1600-9657.1995.tb00473.x.
  • 6. Yassen GH, Platt JA. The effect of nonsetting calcium hydroxide on root fracture and mechanical properties of radicular dentine: a systematic review. Int Endod J. 2013 Feb 46(2):112-8. doi: 10.1111/j.1365-2591.2012.02121.x.
  • 7. Kirmizi D, Aksoy U, Orhan K. Efficacy of Laser-Activated Irrigation and Conventional Techniques in Calcium Hydroxide Removal from Simulated Internal Resorption Cavities: Micro-CT Study. Photobiomodul Photomed Laser Surg. 2021 Oct 39(10):674-81. doi: 10.1089/photob.2021.0001.
  • 8. Kim M, Yang W, Kim H, Ko H. Comparison of the biological properties of ProRoot MTA, OrthoMTA, and Endocem MTA cements. J Endod. 2014 Oct 40(10):1649-53. doi: 10.1016/j.joen.2014.04.013.
  • 9. Bósio CC, Felippe GS, Bortoluzzi EA, Felippe MC, Felippe WT, Rivero ER. Subcutaneous connective tissue reactions to iRoot SP, mineral trioxide aggregate (MTA) Fillapex, DiaRoot BioAggregate and MTA. Int Endod J. 2014 Jul 47(7):667-74. doi: 10.1111/iej.12203.
  • 10. Kim J, Song YS, Min KS, Kim SH, Koh JT, Lee BN, Chang HS, Hwang IN, Oh WM, Hwang YC. Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry. Restor Dent Endod. 2016 Feb 41(1):29-36. doi: 10.5395/rde.2016.41.1.29.
  • 11. Keleş A, Torabinejad M, Keskin C, Sah D, Uzun İ, Alçin H. Micro-CT evaluation of voids using two root filling techniques in the placement of MTA in mesial root canals of Vertucci type II configuration. Clin Oral Investig. 2018 Jun 22(5):1907-1913. doi: 10.1007/s00784-017-2282-0.
  • 12. Andreasen JO. Relationship between surface and inflammatory resorption and changes in the pulp after replantation of permanent incisors in monkeys. J Endod. 1981 Jul 7(7):294-301. doi: 10.1016/S0099-2399(81)80095-7.
  • 13. Heward S, Sedgley CM. Effects of intracanal mineral trioxide aggregate and calcium hydroxide during four weeks on pH changes in simulated root surface resorption defects: an in vitro study using matched pairs of human teeth. J Endod. 2011 Jan 37(1):40-4. doi: 10.1016/j.joen.2010.09.003.
  • 14. Fouad AF, Abbott PV, Tsilingaridis G, Cohenca N, Lauridsen E, Bourguignon C, O'Connell A, Flores MT, Day PF, Hicks L, Andreasen JO, Cehreli ZC, Harlamb S, Kahler B, Oginni A, Semper M, Levin L. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol. 2020 Aug 36(4):331-42. doi: 10.1111/edt.12573.
  • 15. Estrela C, Sydney GB, Bammann LL, Felippe Júnior O. Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria. Braz Dent J. 1995 6(2):85-90.
  • 16. Mohammadi Z, Dummer PM. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Int Endod J. 2011 Aug 44(8):697-730. doi: 10.1111/j.1365-2591.2011.01886.x.
  • 17. Eldeniz AU, Erdemir A, Kurtoglu F, Esener T. Evaluation of pH and calcium ion release of Acroseal sealer in comparison with Apexit and Sealapex sealers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar 103(3):e86-91. doi: 10.1016/j.tripleo.2006.10.018.
  • 18. Sharan K, Siddiqui JA, Swarnkar G, Chattopadhyay N. Role of calcium-sensing receptor in bone biology. Indian J Med Res. 2008 Mar 127(3):274-86.
  • 19. Wong M, Jarrett J, White A, Walsh LJ, George R. Evaluation of the diffusion of calcium hydroxide-based medicaments through the dentinal tubules and apical foramen: A mass spectrometry study. J Conserv Dent. 2021 Nov-Dec 24(6):611-5. doi: 10.4103/jcd.jcd_432_21.
  • 20. Koh ET, Torabinejad M, Pitt Ford TR, Brady K, McDonald F. Mineral trioxide aggregate stimulates a biological response in human osteoblasts. J Biomed Mater Res. 1997 Dec 5;37(3):432-9. doi: 10.1002/(sici)1097-4636(19971205)37:3<432::aid-jbm14>3.0.co;2-d.
  • 21. Chamberlain TM, Kirkpatrick TC, Rutledge RE. pH changes in external root surface cavities after calcium hydroxide is placed at 1, 3 and 5 mm short of the radiographic apex. Dent Traumatol. 2009 Oct 25(5):470-4. doi: 10.1111/j.1600-9657.2009.00806.x.
  • 22. Hansen SW, Marshall JG, Sedgley CM. Comparison of intracanal EndoSequence Root Repair Material and ProRoot MTA to induce pH changes in simulated root resorption defects over 4 weeks in matched pairs of human teeth. J Endod. 2011 Apr;37(4):502-6. doi: 10.1016/j.joen.2011.01.010.
  • 23. Esberard RM, Carnes DL Jr, del Rio CE. Changes in pH at the dentin surface in roots obturated with calcium hydroxide pastes. J Endod. 1996 Aug 22(8):402-5. doi: 10.1016/S0099-2399(96)80239-1.
  • 24. Sevimay S, Kalayci A, Yilmaz S. In vitro diffusion of hydroxyl ions through root dentine from various calcium hydroxide medicaments. J Oral Rehabil. 2003 Oct 30(10):1047-51. doi: 10.1046/j.1365-2842.2003.01081.x.
  • 25. George GK, Rajkumar K, Sanjeev K, Mahalaxmi S. Calcium ion diffusion levels from MTA and ApexCal in simulated external root resorption at middle third of the root. Dent Traumatol. 2009 Oct 25(5):480-3. doi: 10.1111/j.1600-9657.2009.00817.x
  • 26. Camargo CH, Bernardineli N, Valera MC, de Carvalho CA, de Oliveira LD, Menezes MM, Afonso SE, Mancini MN. Vehicle influence on calcium hydroxide pastes diffusion in human and bovine teeth. Dent Traumatol. 2006 Dec 22(6):302-6. doi: 10.1111/j.1600-9657.2005.00326.x.
  • 27. Foster KH, Kulild JC, Weller RN. Effect of smear layer removal on the diffusion of calcium hydroxide through radicular dentin. J Endod. 1993 Mar 19(3):136-40. doi: 10.1016/S0099-2399(06)80508-X.
  • 28. Rehman K, Saunders WP, Foye RH, Sharkey SW. Calcium ion diffusion from calcium hydroxide-containing materials in endodontically-treated teeth: an in vitro study. Int Endod J. 1996 Jul 29(4):271-9. doi: 10.1111/j.1365-2591.1996.tb01381.x.
  • 29. Fridland M, Rosado R. Mineral trioxide aggregate (MTA) solubility and porosity with different water-to-powder ratios. J Endod. 2003 Dec 29(12):814-7. doi: 10.1097/00004770-200312000-00007.
  • 30. de Vasconcelos BC, Bernardes RA, Cruz SM, Duarte MA, Padilha Pde M, Bernardineli N, Garcia RB, Bramante CM, de Moraes IG. Evaluation of pH and calcium ion release of new root-end filling materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jul 108(1):135-9. doi: 10.1016/j.tripleo.2009.02.026.
  • 31. Sarkar NK, Caicedo R, Ritwik P, Moiseyeva R, Kawashima I. Physicochemical basis of the biologic properties of mineral trioxide aggregate. J Endod. 2005 Feb 31(2):97-100. doi: 10.1097/01.don.0000133155.04468.41.
  • 32. Antunes Bortoluzzi E, Juárez Broon N, Antonio Hungaro Duarte M, de Oliveira Demarchi AC, Monteiro Bramante C. The use of a setting accelerator and its effect on pH and calcium ion release of mineral trioxide aggregate and white Portland cement. J Endod. 2006 Dec 32(12):1194-7. doi: 10.1016/j.joen.2006.07.018.
  • 33. Vivan RR, Zapata RO, Zeferino MA, Bramante CM, Bernardineli N, Garcia RB, Hungaro Duarte MA, Tanomaru Filho M, Gomes de Moraes I. Evaluation of the physical and chemical properties of two commercial and three experimental root-end filling materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Aug 110(2):250-6. doi: 10.1016/j.tripleo.2010.04.021.
  • 34. Nerwich A, Figdor D, Messer HH. pH changes in root dentin over a 4-week period following root canal dressing with calcium hydroxide. J Endod. 1993 Jun;19(6):302-6. doi: 10.1016/s0099-2399(06)80461-9.
  • 35. Tronstad L, Andreasen JO, Hasselgren G, Kristerson L, Riis I. pH changes in dental tissues after root canal filling with calcium hydroxide. J Endod. 1981 Jan 7(1):17-21. doi: 10.1016/S0099-2399(81)80262-2.
  • 36. Pérez F, Franchi M, Péli JF. Effect of calcium hydroxide form and placement on root dentine pH. Int Endod J. 2001 Sep 34(6):417-23. doi: 10.1046/j.1365-2591.2001.00409.x.
  • 37. Wu L, Mu Y, Deng X, Zhang S, Zhou D. Comparison of the effect of four decalcifying agents combined with 60°C 3% sodium hypochlorite on smear layer removal. J Endod. 2012 Mar 38(3):381-4. doi: 10.1016/j.joen.2011.11.013.
Yıl 2022, Cilt: 49 Sayı: 3, 108 - 114, 31.12.2022
https://doi.org/10.52037/eads.2022.0035

Öz

Proje Numarası

-

Kaynakça

  • 1. Abbott PV, Lin S. Tooth resorption-Part 2: A clinical classification. Dent Traumatol. 2022 Aug 38(4):267-85. doi:10.1111/edt.12762.
  • 2. Abbott PV. Prevention and management of external inflammatory resorption following trauma to teeth. Aust Dent J. 2016 Mar 61 Suppl 1:82-94. doi:10.1111/adj.12400.
  • 3. Ozdemir HO, Ozçelik B, Karabucak B, Cehreli ZC. Calcium ion diffusion from mineral trioxide aggregate through simulated root resorption defects. Dent Traumatol. 2008 Feb 24(1):70-3. doi:10.1111/j.1600-9657.2006.00512.x.
  • 4. Angkasuvan V, Panichuttra A, Nawachinda M, Ratisoontorn C. Evaluation of pH and calcium ion release at the simulated external root resorption cavities of teeth obturated with bioceramic sealer. Clin Exp Dent Res. 2022 Aug 8(4):900-5. doi: 10.1002/cre2.573.
  • 5. Trope M, Moshonov J, Nissan R, Buxt P, Yesilsoy C. Short vs. long-term calcium hydroxide treatment of established inflammatory root resorption in replanted dog teeth. Endod Dent Traumatol. 1995 Jun 11(3):124-8. doi:10.1111/j.1600-9657.1995.tb00473.x.
  • 6. Yassen GH, Platt JA. The effect of nonsetting calcium hydroxide on root fracture and mechanical properties of radicular dentine: a systematic review. Int Endod J. 2013 Feb 46(2):112-8. doi: 10.1111/j.1365-2591.2012.02121.x.
  • 7. Kirmizi D, Aksoy U, Orhan K. Efficacy of Laser-Activated Irrigation and Conventional Techniques in Calcium Hydroxide Removal from Simulated Internal Resorption Cavities: Micro-CT Study. Photobiomodul Photomed Laser Surg. 2021 Oct 39(10):674-81. doi: 10.1089/photob.2021.0001.
  • 8. Kim M, Yang W, Kim H, Ko H. Comparison of the biological properties of ProRoot MTA, OrthoMTA, and Endocem MTA cements. J Endod. 2014 Oct 40(10):1649-53. doi: 10.1016/j.joen.2014.04.013.
  • 9. Bósio CC, Felippe GS, Bortoluzzi EA, Felippe MC, Felippe WT, Rivero ER. Subcutaneous connective tissue reactions to iRoot SP, mineral trioxide aggregate (MTA) Fillapex, DiaRoot BioAggregate and MTA. Int Endod J. 2014 Jul 47(7):667-74. doi: 10.1111/iej.12203.
  • 10. Kim J, Song YS, Min KS, Kim SH, Koh JT, Lee BN, Chang HS, Hwang IN, Oh WM, Hwang YC. Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry. Restor Dent Endod. 2016 Feb 41(1):29-36. doi: 10.5395/rde.2016.41.1.29.
  • 11. Keleş A, Torabinejad M, Keskin C, Sah D, Uzun İ, Alçin H. Micro-CT evaluation of voids using two root filling techniques in the placement of MTA in mesial root canals of Vertucci type II configuration. Clin Oral Investig. 2018 Jun 22(5):1907-1913. doi: 10.1007/s00784-017-2282-0.
  • 12. Andreasen JO. Relationship between surface and inflammatory resorption and changes in the pulp after replantation of permanent incisors in monkeys. J Endod. 1981 Jul 7(7):294-301. doi: 10.1016/S0099-2399(81)80095-7.
  • 13. Heward S, Sedgley CM. Effects of intracanal mineral trioxide aggregate and calcium hydroxide during four weeks on pH changes in simulated root surface resorption defects: an in vitro study using matched pairs of human teeth. J Endod. 2011 Jan 37(1):40-4. doi: 10.1016/j.joen.2010.09.003.
  • 14. Fouad AF, Abbott PV, Tsilingaridis G, Cohenca N, Lauridsen E, Bourguignon C, O'Connell A, Flores MT, Day PF, Hicks L, Andreasen JO, Cehreli ZC, Harlamb S, Kahler B, Oginni A, Semper M, Levin L. International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. Avulsion of permanent teeth. Dent Traumatol. 2020 Aug 36(4):331-42. doi: 10.1111/edt.12573.
  • 15. Estrela C, Sydney GB, Bammann LL, Felippe Júnior O. Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria. Braz Dent J. 1995 6(2):85-90.
  • 16. Mohammadi Z, Dummer PM. Properties and applications of calcium hydroxide in endodontics and dental traumatology. Int Endod J. 2011 Aug 44(8):697-730. doi: 10.1111/j.1365-2591.2011.01886.x.
  • 17. Eldeniz AU, Erdemir A, Kurtoglu F, Esener T. Evaluation of pH and calcium ion release of Acroseal sealer in comparison with Apexit and Sealapex sealers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Mar 103(3):e86-91. doi: 10.1016/j.tripleo.2006.10.018.
  • 18. Sharan K, Siddiqui JA, Swarnkar G, Chattopadhyay N. Role of calcium-sensing receptor in bone biology. Indian J Med Res. 2008 Mar 127(3):274-86.
  • 19. Wong M, Jarrett J, White A, Walsh LJ, George R. Evaluation of the diffusion of calcium hydroxide-based medicaments through the dentinal tubules and apical foramen: A mass spectrometry study. J Conserv Dent. 2021 Nov-Dec 24(6):611-5. doi: 10.4103/jcd.jcd_432_21.
  • 20. Koh ET, Torabinejad M, Pitt Ford TR, Brady K, McDonald F. Mineral trioxide aggregate stimulates a biological response in human osteoblasts. J Biomed Mater Res. 1997 Dec 5;37(3):432-9. doi: 10.1002/(sici)1097-4636(19971205)37:3<432::aid-jbm14>3.0.co;2-d.
  • 21. Chamberlain TM, Kirkpatrick TC, Rutledge RE. pH changes in external root surface cavities after calcium hydroxide is placed at 1, 3 and 5 mm short of the radiographic apex. Dent Traumatol. 2009 Oct 25(5):470-4. doi: 10.1111/j.1600-9657.2009.00806.x.
  • 22. Hansen SW, Marshall JG, Sedgley CM. Comparison of intracanal EndoSequence Root Repair Material and ProRoot MTA to induce pH changes in simulated root resorption defects over 4 weeks in matched pairs of human teeth. J Endod. 2011 Apr;37(4):502-6. doi: 10.1016/j.joen.2011.01.010.
  • 23. Esberard RM, Carnes DL Jr, del Rio CE. Changes in pH at the dentin surface in roots obturated with calcium hydroxide pastes. J Endod. 1996 Aug 22(8):402-5. doi: 10.1016/S0099-2399(96)80239-1.
  • 24. Sevimay S, Kalayci A, Yilmaz S. In vitro diffusion of hydroxyl ions through root dentine from various calcium hydroxide medicaments. J Oral Rehabil. 2003 Oct 30(10):1047-51. doi: 10.1046/j.1365-2842.2003.01081.x.
  • 25. George GK, Rajkumar K, Sanjeev K, Mahalaxmi S. Calcium ion diffusion levels from MTA and ApexCal in simulated external root resorption at middle third of the root. Dent Traumatol. 2009 Oct 25(5):480-3. doi: 10.1111/j.1600-9657.2009.00817.x
  • 26. Camargo CH, Bernardineli N, Valera MC, de Carvalho CA, de Oliveira LD, Menezes MM, Afonso SE, Mancini MN. Vehicle influence on calcium hydroxide pastes diffusion in human and bovine teeth. Dent Traumatol. 2006 Dec 22(6):302-6. doi: 10.1111/j.1600-9657.2005.00326.x.
  • 27. Foster KH, Kulild JC, Weller RN. Effect of smear layer removal on the diffusion of calcium hydroxide through radicular dentin. J Endod. 1993 Mar 19(3):136-40. doi: 10.1016/S0099-2399(06)80508-X.
  • 28. Rehman K, Saunders WP, Foye RH, Sharkey SW. Calcium ion diffusion from calcium hydroxide-containing materials in endodontically-treated teeth: an in vitro study. Int Endod J. 1996 Jul 29(4):271-9. doi: 10.1111/j.1365-2591.1996.tb01381.x.
  • 29. Fridland M, Rosado R. Mineral trioxide aggregate (MTA) solubility and porosity with different water-to-powder ratios. J Endod. 2003 Dec 29(12):814-7. doi: 10.1097/00004770-200312000-00007.
  • 30. de Vasconcelos BC, Bernardes RA, Cruz SM, Duarte MA, Padilha Pde M, Bernardineli N, Garcia RB, Bramante CM, de Moraes IG. Evaluation of pH and calcium ion release of new root-end filling materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Jul 108(1):135-9. doi: 10.1016/j.tripleo.2009.02.026.
  • 31. Sarkar NK, Caicedo R, Ritwik P, Moiseyeva R, Kawashima I. Physicochemical basis of the biologic properties of mineral trioxide aggregate. J Endod. 2005 Feb 31(2):97-100. doi: 10.1097/01.don.0000133155.04468.41.
  • 32. Antunes Bortoluzzi E, Juárez Broon N, Antonio Hungaro Duarte M, de Oliveira Demarchi AC, Monteiro Bramante C. The use of a setting accelerator and its effect on pH and calcium ion release of mineral trioxide aggregate and white Portland cement. J Endod. 2006 Dec 32(12):1194-7. doi: 10.1016/j.joen.2006.07.018.
  • 33. Vivan RR, Zapata RO, Zeferino MA, Bramante CM, Bernardineli N, Garcia RB, Hungaro Duarte MA, Tanomaru Filho M, Gomes de Moraes I. Evaluation of the physical and chemical properties of two commercial and three experimental root-end filling materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Aug 110(2):250-6. doi: 10.1016/j.tripleo.2010.04.021.
  • 34. Nerwich A, Figdor D, Messer HH. pH changes in root dentin over a 4-week period following root canal dressing with calcium hydroxide. J Endod. 1993 Jun;19(6):302-6. doi: 10.1016/s0099-2399(06)80461-9.
  • 35. Tronstad L, Andreasen JO, Hasselgren G, Kristerson L, Riis I. pH changes in dental tissues after root canal filling with calcium hydroxide. J Endod. 1981 Jan 7(1):17-21. doi: 10.1016/S0099-2399(81)80262-2.
  • 36. Pérez F, Franchi M, Péli JF. Effect of calcium hydroxide form and placement on root dentine pH. Int Endod J. 2001 Sep 34(6):417-23. doi: 10.1046/j.1365-2591.2001.00409.x.
  • 37. Wu L, Mu Y, Deng X, Zhang S, Zhou D. Comparison of the effect of four decalcifying agents combined with 60°C 3% sodium hypochlorite on smear layer removal. J Endod. 2012 Mar 38(3):381-4. doi: 10.1016/j.joen.2011.11.013.
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Diş Hekimliği
Bölüm Original Research Articles
Yazarlar

Umut Aksoy 0000-0001-7281-508X

Kaan Polatoğlu 0000-0001-5493-2995

Feridun Şaklar 0000-0001-5339-9068

Proje Numarası -
Yayımlanma Tarihi 31 Aralık 2022
Gönderilme Tarihi 23 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 49 Sayı: 3

Kaynak Göster

Vancouver Aksoy U, Polatoğlu K, Şaklar F. Evaluation of pH and Calcium Ion Diffusion from Intracanal MTA and Bioaggregate to Simulated External Resorption Cavities Through Dentinal Tubules. EADS. 2022;49(3):108-14.