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Yıl 2023, Cilt: 19 Sayı: 4, 333 - 341, 29.12.2023

Muhammet Burak Batir

https://doi.org/10.18466/cbayarfbe.1336250

Öz

Kaynakça

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  • [3]. Xue, J., Chen, K., Hu, H., & Gopinath, S. C. B. (2022). Progress in gene therapy treatments for prostate cancer. Biotechnology and applied biochemistry, 69(3), 1166–1175. https://doi.org/10.1002/bab.2193
  • [4]. Oztatlici, H., Oztatlici, M., Daglı, S. N., & Karadeniz Saygili, S. (2022). Bir sefalosporin olan sefepim, nb2a nöroblastoma hücrelerinde apoptozu ve oksidatif stresi indükler. Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences, 9(21), 79–86. https://doi.org/10.38065/euroasiaorg.962
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Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines

Yıl 2023, Cilt: 19 Sayı: 4, 333 - 341, 29.12.2023

Muhammet Burak Batir

https://doi.org/10.18466/cbayarfbe.1336250

Öz

Abstract: At the core of gene therapy lies the use of viral vectors, engineered viruses serving as delivery vehicles to transport restorative genes into target cells. Therefore, the effect of 7 different rAAV serotypes and their different quantites was analysis here on human prostate cancer cell lines PC-3 and DU-145, which are hard to be transfected. PC-3 and DU-145 cell lines were infected with different multiplicity of infection (MOI) ratios of 7 rAAV serotypes, AAV 2/1, 2/2, 2/3, 2/5, 2/6, and 2/9, which were expressing the green fluorescent protein (GFP) transgene driven by the CMV promoter. The transduction efficiency was analyzed by fluorescent microscopy and flow cytometry. In addition, the cell viability of the infected cells was measured by Muse Cell Analyzer at the MOI of 10.000. rAAV 2/2 and rAAV 2/6 have the most significant ability to transduce PC-3 cells. Although rAAV 2/2 and rAAV 2/6 were also the most transducing serotypes in the DU-145 cell line, the transduction rates did not exceed 20% in this cell line. On the other hand, after viral infection, no difference in cell viability was observed in PC-3 cells compared to the mock group, while a significant decrease in viability was observed in DU-145 cells. This study determined the transduction efficiency of 7 different rAAV serotypes on human cancer cell lines. While rAAV 2/2 and rAAV 2/6 serotypes achieved more than 60% transduction efficiency in PC-3 cells, the transduction efficiency could not exceed 20% in DU-145 cells. Overall, this study demonstrated that rAAV 2/2 and rAAV 2/6 could mediate the expression of a transgene with a high transduction efficiency.

Anahtar Kelimeler

Cancer Gene therapy rAAV Recombinant adeno-associated virus Transduction

Kaynakça

  • [1]. Sekhoacha, M., Riet, K., Motloung, P., Gumenku, L., Adegoke, A., & Mashele, S. (2022). Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches. Molecules (Basel, Switzerland), 27(17), 5730. https://doi.org/10.3390/molecules27175730
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  • [3]. Xue, J., Chen, K., Hu, H., & Gopinath, S. C. B. (2022). Progress in gene therapy treatments for prostate cancer. Biotechnology and applied biochemistry, 69(3), 1166–1175. https://doi.org/10.1002/bab.2193
  • [4]. Oztatlici, H., Oztatlici, M., Daglı, S. N., & Karadeniz Saygili, S. (2022). Bir sefalosporin olan sefepim, nb2a nöroblastoma hücrelerinde apoptozu ve oksidatif stresi indükler. Euroasia Journal of Mathematics, Engineering, Natural & Medical Sciences, 9(21), 79–86. https://doi.org/10.38065/euroasiaorg.962
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  • [8]. Chen, M., Mao, A., Xu, M., Weng, Q., Mao, J., & Ji, J. (2019). CRISPR-Cas9 for cancer therapy: Opportunities and challenges. Cancer letters, 447, 48–55. https://doi.org/10.1016/j.canlet.2019.01.017
  • [9]. Sun, W., Shi, Q., Zhang, H., Yang, K., Ke, Y., Wang, Y., & Qiao, L. (2019). Advances in the techniques and methodologies of cancer gene therapy. Discovery medicine, 27(146), 45–55.
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  • [16]. Zincarelli, C., Soltys, S., Rengo, G., & Rabinowitz, J. E. (2008). Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection. Molecular therapy : the journal of the American Society of Gene Therapy, 16(6), 1073–1080. https://doi.org/10.1038/mt.2008.76
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  • [20]. Verdera, H. C., Kuranda, K., & Mingozzi, F. (2020). AAV Vector Immunogenicity in Humans: A Long Journey to Successful Gene Transfer. Molecular therapy : the journal of the American Society of Gene Therapy, 28(3), 723–746. https://doi.org/10.1016/j.ymthe.2019.12.010
  • [21]. Choi, V. W., McCarty, D. M., & Samulski, R. J. (2005). AAV hybrid serotypes: improved vectors for gene delivery. Current gene therapy, 5(3), 299–310. https://doi.org/10.2174/1566523054064968
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  • [28]. Aurnhammer, C., Haase, M., Muether, N., Hausl, M., Rauschhuber, C., Huber, I., Nitschko, H., Busch, U., Sing, A., Ehrhardt, A., & Baiker, A. (2012). Universal real-time PCR for the detection and quantification of adeno-associated virus serotype 2-derived inverted terminal repeat sequences. Human gene therapy methods, 23(1), 18–28. https://doi.org/10.1089/hgtb.2011.034
  • [29]. Muraine, L., Bensalah, M., Dhiab, J., Cordova, G., Arandel, L., Marhic, A., Chapart, M., Vasseur, S., Benkhelifa-Ziyyat, S., Bigot, A., Butler-Browne, G., Mouly, V., Negroni, E., & Trollet, C. (2020). Transduction Efficiency of Adeno-Associated Virus Serotypes After Local Injection in Mouse and Human Skeletal Muscle. Human gene therapy, 31(3-4), 233–240. https://doi.org/10.1089/hum.2019.173
  • [30]. Berns, K. I., & Srivastava, A. (2019). Next Generation of Adeno-Associated Virus Vectors for Gene Therapy for Human Liver Diseases. Gastroenterology clinics of North America, 48(2), 319–330. https://doi.org/10.1016/j.gtc.2019.02.005
  • [31]. Zengel, J., & Carette, J. E. (2020). Structural and cellular biology of adeno-associated virus attachment and entry. Advances in virus research, 106, 39–84. https://doi.org/10.1016/bs.aivir.2020.01.002
  • [32]. Chow, R. D., Guzman, C. D., Wang, G., Schmidt, F., Youngblood, M. W., Ye, L., Errami, Y., Dong, M. B., Martinez, M. A., Zhang, S., Renauer, P., Bilguvar, K., Gunel, M., Sharp, P. A., Zhang, F., Platt, R. J., & Chen, S. (2017). AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature neuroscience, 20(10), 1329–1341. https://doi.org/10.1038/nn.4620
  • [33]. Hung, S. S., Chrysostomou, V., Li, F., Lim, J. K., Wang, J. H., Powell, J. E., Tu, L., Daniszewski, M., Lo, C., Wong, R. C., Crowston, J. G., Pébay, A., King, A. E., Bui, B. V., Liu, G. S., & Hewitt, A. W. (2016). AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo. Investigative ophthalmology & visual science, 57(7), 3470–3476. https://doi.org/10.1167/iovs.16-19316
  • [34]. Miller, D. G., Petek, L. M., & Russell, D. W. (2003). Human gene targeting by adeno-associated virus vectors is enhanced by DNA double-strand breaks. Molecular and cellular biology, 23(10), 3550–3557. https://doi.org/10.1128/MCB.23.10.3550-3557.2003
  • [35]. Batır, M. B., Şahin, E., & Çam, F. S. (2019). Evaluation of the CRISPR/Cas9 directed mutant TP53 gene repairing effect in human prostate cancer cell line PC-3. Molecular biology reports, 46(6), 6471–6484. https://doi.org/10.1007/s11033-019-05093-y
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  • [37]. Lino, C. A., Harper, J. C., Carney, J. P., & Timlin, J. A. (2018). Delivering CRISPR: a review of the challenges and approaches. Drug delivery, 25(1), 1234–1257. https://doi.org/10.1080/10717544.2018.1474964
  • [38]. Maestro, S., Weber, N. D., Zabaleta, N., Aldabe, R., & Gonzalez-Aseguinolaza, G. (2021). Novel vectors and approaches for gene therapy in liver diseases. JHEP reports : innovation in hepatology, 3(4), 100300. https://doi.org/10.1016/j.jhepr.2021.100300
  • [39]. Chen, C., Akerstrom, V., Baus, J., Lan, M. S., & Breslin, M. B. (2013). Comparative analysis of the transduction efficiency of five adeno associated virus serotypes and VSV-G pseudotype lentiviral vector in lung cancer cells. Virology journal, 10, 86. https://doi.org/10.1186/1743-422X-10-86
  • [40]. Alves, S., Bode, J., Bemelmans, A. P., von Kalle, C., Cartier, N., & Tews, B. (2016). Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain. Scientific reports, 6, 28272. https://doi.org/10.1038/srep28272
  • [41]. Chen, X., He, Y., Tian, Y., Wang, Y., Wu, Z., Lan, T., Wang, H., Cheng, K., & Xie, P. (2020). Different Serotypes of Adeno-Associated Virus Vector- and Lentivirus-Mediated Tropism in Choroid Plexus by Intracerebroventricular Delivery. Human gene therapy, 31(7-8), 440–447. https://doi.org/10.1089/hum.2019.300 [42]. Korneyenkov, M. A., & Zamyatnin, A. A., Jr (2021). Next Step in Gene Delivery: Modern Approaches and Further Perspectives of AAV Tropism Modification. Pharmaceutics, 13(5), 750. https://doi.org/10.3390/pharmaceutics13050750
  • [43]. Van Vliet, K. M., Blouin, V., Brument, N., Agbandje-McKenna, M., & Snyder, R. O. (2008). The role of the adeno-associated virus capsid in gene transfer. Methods in molecular biology (Clifton, N.J.), 437, 51–91. https://doi.org/10.1007/978-1-59745-210-6_2
  • [44]. Wu, Z., Asokan, A., & Samulski, R. J. (2006). Adeno-associated virus serotypes: vector toolkit for human gene therapy. Molecular therapy : the journal of the American Society of Gene Therapy, 14(3), 316–327. https://doi.org/10.1016/j.ymthe.2006.05.009
Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çözelti Kimyası
Bölüm Makaleler
Yazarlar

Muhammet Burak Batir 0000-0002-8722-5055

Yayımlanma Tarihi 29 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 19 Sayı: 4

Kaynak Göster

APA Batir, M. B. (2023). Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines. Celal Bayar University Journal of Science, 19(4), 333-341. https://doi.org/10.18466/cbayarfbe.1336250
AMA Batir MB. Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines. CBUJOS. Aralık 2023;19(4):333-341. doi:10.18466/cbayarfbe.1336250
Chicago Batir, Muhammet Burak. “Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines”. Celal Bayar University Journal of Science 19, sy. 4 (Aralık 2023): 333-41. https://doi.org/10.18466/cbayarfbe.1336250.
EndNote Batir MB (01 Aralık 2023) Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines. Celal Bayar University Journal of Science 19 4 333–341.
IEEE M. B. Batir, “Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines”, CBUJOS, c. 19, sy. 4, ss. 333–341, 2023, doi: 10.18466/cbayarfbe.1336250.
ISNAD Batir, Muhammet Burak. “Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines”. Celal Bayar University Journal of Science 19/4 (Aralık 2023), 333-341. https://doi.org/10.18466/cbayarfbe.1336250.
JAMA Batir MB. Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines. CBUJOS. 2023;19:333–341.
MLA Batir, Muhammet Burak. “Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines”. Celal Bayar University Journal of Science, c. 19, sy. 4, 2023, ss. 333-41, doi:10.18466/cbayarfbe.1336250.
Vancouver Batir MB. Recombinant Adeno-Associated Viral Vector Transduction of Human Prostate Cancer Cell Lines. CBUJOS. 2023;19(4):333-41.
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