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Congenital Leukemia Initially Presenting with Leukemia Cutis

Year 2012, Volume: 10 Issue: 3, 103 - 106, 01.12.2012
https://doi.org/10.4274/Jcp.10.06

Abstract

Introduction: Congenital leukemia represents less than 1% of childhood leukemia. Itsprognosis is poor. Myeloid form is the most common type, and leukemia cutis hasbeen observed in 25-30% of the patients. These skin lesions are defined as ‘blueberrymuffin’ type which are blue-violaceous and usually multiple and diffuse nodules. Case Report: She had diffuse blue-violaceous nodules since birth. She hospitalized dueto sepsis for 35 days. She was referred to our center with the suspicion of immunedeficiency. The initial physical findings were severe pallor, diffuse blue-violaceoussubcutanose nodules and hepatosplenomegaly. The leucocyte count was found 363 000/mm3. Acute monositer leukemia AML-M5 was determined with morphologicand flow cytometric evaluation of the peripheral blood. Conclusion: Congenital leukemia must be thought in differential diagnosis from otherunderlying disease presenting with blueberry muffin skin lesions

References

  • 1. Weitzman S, Grant R. Neonatal oncology: diagnostic and therapeutic dilemmas. Semin Perinatol 1997;21:102-11.
  • 2. Resnik KS, Brod BB. Leukemia cutis in congenital leukema. Analysis and review of the world literature with report of an additional case. Arc Dermatol 1993;129:1301-6.
  • 3. Torrelo A, Madero L, Mediero IG, Bano A, Zambrano A. Aleukemic congenital leukemia cutis. Pediatr Dermatol 2004;21:458-61.
  • 4. Loh ML, Matthay KK. Congenital malignant disorder. In: Taeusch HW, Ballard RA, Gleason CA, editors. Avery’s diseases of the newborn. 8th ed. Philadelphia: Elsevier Saunders, 2005.p.1450.
  • 5. D'Orazio JA, Pulliam JF, Moscow JA. Spontaneous resolution of a single lesion of myeloid leukemia cutis in an infant: case report and discussion. Pediatr Hematol Oncol 2008;25:457-68.
  • 6. Landers MC, Malempati S, Tilford D, Gatter K, White C, Schroeder TL. Spontaneous regression of aleukemia congenital leukemia cutis. Pediatr Dermatol 2005;22:26-30.
  • 7. Bayoumy M, Wynn T, Jamil A, Kahwash S, Klopfenstein K, Ruymann F. Prenatal presentation supports the in utero development of congenital leukemia: a case report. J Pediatr Hematol Oncol 2003;25:148-52.
  • 8. Kaneko Y, Shikano T, Maseki N, Sakurai M, Sakurai M, Takeda T, et al. Clinical characteristics of infant acute leukemia with or without 11q23 translocations. Leukemia 1988;2:672-6.
  • 9. Liu H, Cheng EH, Hsieh JJ. MLL fusions: pathways to leukemia. Cancer Biol Ther 2009;8:1204-11.
  • 10. Silverman LB. Acute lymphoblastic leukemia in infancy. Pediatr Blood Cancer. 2007; 49(Suppl 7):1070-3.
  • 11. Bresters D, Reus AC, Veerman AJ, van Wering ER, van der Does-van den Berg A, Kaspers GJ. Congenital leukaemia: the Dutch experience and review of the literature. Br J Haematol 2002;117:513-24.
  • 12. Zhang IH, Zane LT, Braun BS, Maize J Jr, Zoger S, Loh ML.Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol 2006;54(Suppl 2):22-7.
  • 13. van Dongen JC, Dalinghaus M, Kroon AA, de Vries AC, van den Heuvel-Eibrink MM. Successful treatment of congenital acute myeloid leukemia (AML-M6) in a premature infant. J Pediatr Hematol Oncol 2009;31:853-4.
  • 14. Choi JH, Lee HB, Park CW, Lee CH. A case of congenital leukemia cutis. Ann Dermatol 2009;21:66-70.
  • 15. Akcakus M, Patiroglu T, Deniz K, Cetin N, Ozdemir MA, Kala M. Congenital acute lymphoblastic leukemia: report of a case with leukemia cutis. Clin Pediatr 2004;43:487-90.

İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi

Year 2012, Volume: 10 Issue: 3, 103 - 106, 01.12.2012
https://doi.org/10.4274/Jcp.10.06

Abstract

Giriş: Konjenital lösemi, çocukluk çağı lösemilerinin %1’inden azını oluşturur.Prognozu kötüdür. En sık miyeloid form görülür. Olguların %25-30’unda lösemik cilttutulumu bulunur. ‘Blueberry muffin’ denilen bu lezyonlar; mavi-mor renkli, sıklıkla çoksayıda ve yaygın nodüler lezyonlardır. Olgu Sunumu: Doğduğundan beri yaygın mavi-mor renkli nodüler lezyonları olan, sepsisdüşünülerek yenidoğan ünitesinde 35 gün izlenen hasta, immün yetmezlik ön tanısı ilemerkezimize yönlendirilmiştir. Fizik bakısında; soluk görünümde, tüm vücudunda yaygın,mavi-mor renkli cilt altı nodüler lezyonları ve hepatosplenomegali saptandı. Lökositsayısı 363 000/mm3değerlendirilmesi ile Akut Monositer Lösemi AML-M5 tanısı aldı.Tartışma: “Blueberry muffin” cilt lezyonları ile gelen hastalarda mutlaka konjenitallösemi ayırt edilmelidir

References

  • 1. Weitzman S, Grant R. Neonatal oncology: diagnostic and therapeutic dilemmas. Semin Perinatol 1997;21:102-11.
  • 2. Resnik KS, Brod BB. Leukemia cutis in congenital leukema. Analysis and review of the world literature with report of an additional case. Arc Dermatol 1993;129:1301-6.
  • 3. Torrelo A, Madero L, Mediero IG, Bano A, Zambrano A. Aleukemic congenital leukemia cutis. Pediatr Dermatol 2004;21:458-61.
  • 4. Loh ML, Matthay KK. Congenital malignant disorder. In: Taeusch HW, Ballard RA, Gleason CA, editors. Avery’s diseases of the newborn. 8th ed. Philadelphia: Elsevier Saunders, 2005.p.1450.
  • 5. D'Orazio JA, Pulliam JF, Moscow JA. Spontaneous resolution of a single lesion of myeloid leukemia cutis in an infant: case report and discussion. Pediatr Hematol Oncol 2008;25:457-68.
  • 6. Landers MC, Malempati S, Tilford D, Gatter K, White C, Schroeder TL. Spontaneous regression of aleukemia congenital leukemia cutis. Pediatr Dermatol 2005;22:26-30.
  • 7. Bayoumy M, Wynn T, Jamil A, Kahwash S, Klopfenstein K, Ruymann F. Prenatal presentation supports the in utero development of congenital leukemia: a case report. J Pediatr Hematol Oncol 2003;25:148-52.
  • 8. Kaneko Y, Shikano T, Maseki N, Sakurai M, Sakurai M, Takeda T, et al. Clinical characteristics of infant acute leukemia with or without 11q23 translocations. Leukemia 1988;2:672-6.
  • 9. Liu H, Cheng EH, Hsieh JJ. MLL fusions: pathways to leukemia. Cancer Biol Ther 2009;8:1204-11.
  • 10. Silverman LB. Acute lymphoblastic leukemia in infancy. Pediatr Blood Cancer. 2007; 49(Suppl 7):1070-3.
  • 11. Bresters D, Reus AC, Veerman AJ, van Wering ER, van der Does-van den Berg A, Kaspers GJ. Congenital leukaemia: the Dutch experience and review of the literature. Br J Haematol 2002;117:513-24.
  • 12. Zhang IH, Zane LT, Braun BS, Maize J Jr, Zoger S, Loh ML.Congenital leukemia cutis with subsequent development of leukemia. J Am Acad Dermatol 2006;54(Suppl 2):22-7.
  • 13. van Dongen JC, Dalinghaus M, Kroon AA, de Vries AC, van den Heuvel-Eibrink MM. Successful treatment of congenital acute myeloid leukemia (AML-M6) in a premature infant. J Pediatr Hematol Oncol 2009;31:853-4.
  • 14. Choi JH, Lee HB, Park CW, Lee CH. A case of congenital leukemia cutis. Ann Dermatol 2009;21:66-70.
  • 15. Akcakus M, Patiroglu T, Deniz K, Cetin N, Ozdemir MA, Kala M. Congenital acute lymphoblastic leukemia: report of a case with leukemia cutis. Clin Pediatr 2004;43:487-90.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Melike Sezgin Evim

Meliha Demiral This is me

Publication Date December 1, 2012
Published in Issue Year 2012 Volume: 10 Issue: 3

Cite

APA Evim, M. S., & Demiral, M. (2012). İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi. Güncel Pediatri, 10(3), 103-106. https://doi.org/10.4274/Jcp.10.06
AMA Evim MS, Demiral M. İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi. Güncel Pediatri. December 2012;10(3):103-106. doi:10.4274/Jcp.10.06
Chicago Evim, Melike Sezgin, and Meliha Demiral. “İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi”. Güncel Pediatri 10, no. 3 (December 2012): 103-6. https://doi.org/10.4274/Jcp.10.06.
EndNote Evim MS, Demiral M (December 1, 2012) İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi. Güncel Pediatri 10 3 103–106.
IEEE M. S. Evim and M. Demiral, “İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi”, Güncel Pediatri, vol. 10, no. 3, pp. 103–106, 2012, doi: 10.4274/Jcp.10.06.
ISNAD Evim, Melike Sezgin - Demiral, Meliha. “İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi”. Güncel Pediatri 10/3 (December 2012), 103-106. https://doi.org/10.4274/Jcp.10.06.
JAMA Evim MS, Demiral M. İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi. Güncel Pediatri. 2012;10:103–106.
MLA Evim, Melike Sezgin and Meliha Demiral. “İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi”. Güncel Pediatri, vol. 10, no. 3, 2012, pp. 103-6, doi:10.4274/Jcp.10.06.
Vancouver Evim MS, Demiral M. İlk Bulgusu Cilt Tutulumu Olan Konjenital Lösemi. Güncel Pediatri. 2012;10(3):103-6.