Research Article
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In vitro antimicrobial, antioxidant and anti-inflammatory evaluation of Eucalyptus globulus essential oil

Year 2020, Volume: 7 Issue: 3, 1 - 11, 07.09.2020

Gamze Göger Nursenem Karaca Betül Büyükkılıç Betül Demirci Fatih Demirci

Abstract

Eradication of Propionibacterium acnes and associated skin pathogenic species such as Staphylococcus aureus and S. epidermidis
involve anti-oxidant as well as anti-inflammatory effects besides antimicrobial action. For this purpose, Pharmacopoeia Grade (PhEur)
Eucalyptus globulus essential oil was evaluated against the human pathogenic species such as P. acnes ATCC 6919, P. acnes ATCC
11827, S. aureus ATCC 6538 and S. epidermidis ATCC 12228 using an in vitro microdilution method. The composition and quality of
the essential oil was confirmed both by GC/FID and GC/MS techniques, respectively. The in vitro radical-scavenging activity was
evaluated using the photometric 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay; the anti-inflammatory activity assay performed
by using the in vitro lipoxygenase (5-LOX) enzyme inhibition assay. Essential oil analysis confirmed the presence of 1,8-cineole (80.2
%), p-cymene (6.6 %), and limonene (5 %) as main components. The antibacterial performance of the tested oil was more susceptible
against Staphylococcus species (MIC=625 µg/mL) compared to P. acnes (MIC=1250 µg/mL). 5-LOX inhibitory activity was determined
as IC50 = 58 ±1,4 µg/mL for the essential oil, compared to the inhibition of the standard nordihydroguaiaretic acid = NDGA. The
preliminary experimental results suggest that the Eucalyptus essential oil and its major constituent 1,8-cineole acts against skin
pathogenic bacteria as a mild natural antimicrobial with anti-inflammatory effects, for further potential topical applications. 

Keywords

: Antibacterial anti-inflammatory Eucalyptus globulus Propionibacterium acnes Staphylococcus

Supporting Institution

Anadolu Üniversite Bilimsel Araştırma Projeleri Birimi

Project Number

AUBAP: 1301S005

Thanks

The authors would like to thank Anadolu University Scientific Research Project 1301S005 for the financial support.

References

  • Abascal, K., Yarnell, E (2002).Herbs and drug resistance: Potential of botanical in drug-resistant microbes, Alternive of Complementary Therapies, 8, 237-241.
  • Anonymous (2008). Determination of essential oils in herbal drugs, European Pharmacopoeia 6.0-2.8.12. European Council, Strasbourg, pp. 251
  • Akolade, J.O., Olajide, O.O., Afolayan, M.O., Akande, S.A., Idowu, D.I., Orishadipe, A.T. (2012) Chemical composition, antioxidant and cytotoxic effects of Eucalyptus globulus grown in north-central Nigeria. Journal of Natural Product and Plant Resources. 2(1), 1-8.
  • Athikomkulchai, S., Watthanachaiyingcharoen, R., Tunvichien, S., Vayumhasuwan, P., Karnsomkiet, P., Sae-Jong, P., Ruangrungsi, N. (2008). The development of anti-acne products from Eucalyptus globulus and Psidium Guajava oil. Journal of Health Researchi 22(3), 109-113.
  • Babar, A., Naser, A., Saiba, S., Aftab, A., Shah, Alam, K., Firoz, A. (2015). Essential oils used in aromatherapy: A systemic review. Asian Pacific Journal of Tropical Biomedicine, 5(8), 601-611.
  • Bachir, R.G., Benali, M. (2012). Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pacific Journal of Tropical Biomedicine, 2(9): 739-742.
  • Bhatt, D., Sachan, A.K., Jain, S., Barik, R. (2011). Studies on inhibitory effect of Eucalyptus oil on sebaceous glands for the management of acne. Indian Journal of Natural Product Resources, 2 (3): 345-349.
  • Bansod, S., Rai, M. (2008). Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World Journal of Medicine and Medical Science. 3(2), 81-88.
  • Bassole, I.H.N., Juliani, H.R. (2012). Essential oils in combination and their antimicrobial properties. Molecules, 17 (4), 3989-4006.
  • Baylac, S., Racine, P. (2003). Inhibition of 5-Lipoxygenase by essential oils and other natural fragrant extracts. International Journal of Aromatheraphy, 13(2-3), 38-142.
  • Başer, K.H.C., Buchbauer, G. (2015). Handbook of Essential Oils: Science, Technology, and Applications, second ed., Taylor and Francis, USA.
  • Chouhan, S., Sharma, K., Guleria, S. (2017). Antimicrobial activity of some essential oils-present status and future perspectives. Medicines, 4 (3), 58.
  • Chomnawang, M.T., Surassmo, S., Nukoolkarn, V.S., Gritsanapan, W. (2005). Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. Journal of Ethnopharmacology, 101(1-3), 330-333.
  • Clinical and Laboratory Standards Institute (CLSI). (2006). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, CLSI M7-A7, 940 West Valley Road Wayne, Pennsylvania, USA.
  • Damjanovic-Vratnica, B., Dakov, T., Sukovic, D., Damjanovic, J.. (2001). Antimicrobial effect of essential oil isolated from Eucalyptus globulus Labill. from Montenegro. Czech Journal of Food Sciences, 29(3), 277-284.
  • Das, S., Reynolds, R.V. (2014). Recent advances in acne pathogenesis: implications for therapy. American Journal of Clinical Dermatology, 15 (6), 479-488.
  • Dey, P., Karuna, D.S., Bhakta, T. (2014). Medicinal plants used as anti-acne agents by tribal and non-tribal people of Tripura, India. American Journal of Phytomedicine and Clinical Therapeutics, 2(5), 556-570.
  • Deyno, S., Mtewa, A.G., Abebe, A., Hymete, A., Makonnen, E., Bazira, J., Alele, P.E. (2019). Essential oils as topical anti-infective agents: A systematic review and meta-analysis. Complementary Therapies in Medicine 47, 102224.
  • Dzamic, A.M., Sokovic, M.D., Novakovic, M., Jadranin, M., Ristic, M.S., Tesevic, V., Marin P.D. (2013). Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp. pilifer (Pant.) Murb. essential oil and deodorized extracts. Industrial Crops and Product, 51, 401-407.
  • do Rosario Martins, M., Arantes, S., Candeias, F., Tinoco, M.T., Cruz-Morais, J. (2014). Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils. Journal of Ethnopharmacology 151(1), 485-492.
  • Ergin, Ç., Ergin, Ş., Kaleli, İ., Şengül, M., Erdoğan, B.Ş. (2007). Screening of antibiotic resistant Propionibacterium acnes from Acne vulgaris patients: Data from Pamukkale University. Türkderm, 41, 19-21.
  • ESO (2000). The Complete Database of Essential Oils, Boelens Aroma Chemical Information Service, The Netherlands. Ghalem, B.R., Mohamed, B. (2008). Antibacterial activity of leaf essential oils of Eucalyptus globulus and Eucalyptus camaldulensis. African Journal of Pharmacy and Pharmacology, 2(10), 211-215.
  • Harkat-Madouri, L., Asma, B., Madani, K., Said, Z.B.O.S., Rigou, P., Grenier, D., Boulekbache-Makhlouf, L. (2015). Chemical composition, antibacterial and antioxidant activities of essential oil of Eucalyptus globulus from Algeria. Industrial Crops and Product, 78, 148-153.
  • Hammer, K.A. (2015). Treatment of acne with tea tree oil (melaleuca) products: a review of efficacy, tolerability and potential modes of action. International Journal of Antimicrobial Agents, 45(2), 106-110.
  • Joulain, D., Koenig, W.A. (1998). The Atlas of Spectra Data of Sesquiterpene Hydrocarbons, EB-Verlag, Hamburg. Koenig, W.A., Joulain, D., Hochmuth, D.H. (2004). Terpenoids and Related Constituents of Essential Oils, MassFinder 3, Hamburg, Germany.
  • Kumarasamy, Y., Byres, M., Cox, P.J., Jaspars, M., Nahar, L., Sarker, S.D. (2007). Screening seeds of some Scottish plants for free radical scavenging activity. Phytotheraphy Research, 21(7): 615-621.
  • Kuhn, H. (2000). Structural basis for the positional specificity of lipoxygenase, Prostaglandins & other lipid mediators, 62(3), 255-270.
  • Lertsatitthanakorn, P., Taweechaisupapong, S., Aromdee, C., Khunkitti, W. (2006). In vitro bioactivities of essential oils used for acne control. International Jornal of Aromatheraphy, 16 (1), 43-49. Leone, S., Ottani, A., Bertolini, A. (2007). Dual Acting anti-inflammatory drugs. Current Topics in Medicinal Chemistry, 7(3): 265-275.
  • Luangnarumitchai, S., Lamlertthon, S., Tiyaboonchai, W. (2007). Antimicrobial activity of essential oils against five strains of Propionibacterium acnes. Mahidol University Journal of Pharmaceutical Sciences. 34(1-4), 60-64.
  • Luis, A., Duarte, A., Gominho, J., Domingues, F., Duarte, A.P. (2016). Chemical composition, antioxidant, antibacterial and anti-quorum sensing activities of Eucalyptus globulus and Eucalyptus radiata essential oils. Industrial Crops and Product,79, 274-282.
  • Maccioni, A.M., Anchisi, C., Sanna, A., Sardu, C., Dessi, S. (2002). Preservative systems containing essential oils in cosmetic products. International Journal of Cosmetic Sciences, 24(1), 53-59.
  • Mekonnen, A., Yitayew, B., Tesema, A., Taddese, S. (2016). In vitro antimicrobial activity of essential oil of Thymus schimperi, Matricaria chamomilla, Eucalyptus globulus and Rosmarinus officinalis. International Journal of Microbiology, 1-8.
  • McLafferty, F.W., Stauffer, D.B. (1989). The Wiley/NBS Registry of Mass Spectral Data, John Wiley and Sons, New York 1989.
  • Noumi, E., Snoussi, M., Hajlaoui, H., Trabelsi, N., Ksouri, R., Valentin, E., Bakhrouf, A. (2011) Chemical composition, antioxidant and antifungal potential of Melaleuca alternifolia (Tea Tree) and Eucalyptus globulus essential oils against oral Candida species. Journal of Medicinal Plant Research 5(17), 4147-4156.
  • Orafidiya, L., Agbani, E., Oyedele, A., Babalola, O., Onayemi, O. (2002). Preliminary clinical tests on topical preparations of Ocimum gratissimum Linn leaf essential oil for the treatment of acne vulgaris. Clinical Drug Investigtaion, 22(5), 313-319.
  • Orchard, A., Sandasi, M., Kamatou, G., Viljoen, A., Van Vuuren, S. (2017). The in vitro antimicrobial activity and chemometric modelling of 59 commercial essential oils against pathogens of dermatological relevance. Chemistry & Biodiversity, 14(1), e1600218.
  • Orchard, A., Van Vuuren, S.F., Viljoen, A.M., Kamatou, G. (2018). The in vitro antimicrobial evaluation of commercial essential oils and their combinations against acne. International Journal of Cosmetic Sciences, 40 (3), 226-243.
  • Pfaller, M.A., Chaturvedi, V., Diekema, D.J., Ghannoum, M.A., Holliday, N.M., Killian, S.B., Knapp C.C., Messer, S.A., Miskov. A., Ramani, R. (2008). Clinical evaluation of the Sensititre Yeast One colorimetric antifungal panel for antifungal susceptibility testing of the echinocandins anidulafungin, caspofungin, and micafungin. Journal of Clinical Microbiology, 46(7), 2155-2159.
  • Perry, A.L., Lambert, P.A. (2006). Propionibacterium acnes. Letters in Applied Microbiology, 42, 185-188.
  • Sacchetti, G., Maietti, S., Muzzoli, M., Scaglianti, M., Manfredini, S., Radice, M., Bruni, R. (2005). Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chemistry, 91(4), 621-632.
  • Said, Z., Haddadi-Guemghar, H., Boulekbache-Makhlouf, L., Rigou, P., Remini, H., Adjaoud, A., Madani, K. (2016). Essential oils composition, antibacterial and antioxidant activities of hydrodistillated extract of Eucalyptus globulus fruits. Industrial Crops and Product, 89, 167-175.
  • Salari, M., Amine, G., Shirazi, M., Hafezi, R., Mohammadypour, M. (2006). Antibacterial effects of Eucalyptus globulus leaf extract on pathogenic bacteria isolated from specimens of patients with respiratory tract disorders. Clinical Microbiology and Infection, 12(2), 194-196.
  • Serpi, M., Özdemir, Z.Ö., Salman, Y. (2012). Investigation of the antibacterial effects of some plant extracts on Propionibacterium acnes, KSU Journal of Natural Sciences, 15.
  • Silva, J., Abebe, W., Sousa, S.M., Duarte, V.G., Machado, M.I.L. Matos, F.J.A. (2003). Analgesic and anti-inflammatory effects of essential oils of Eucalyptus, Journal of Ethnopharmacology, 89(2-3): 277-283.
  • Sonboli, A., Babakhani, B., Mehrabian, A.R. (2006). Antimicrobial activity of six constituents of essential oil from Salvia. Zeitschrift für Naturforschung C, 61(3-4), 160-164.
  • Taleb, M., Abdeltawab, N., Shamma, R., Abdelgayed, S., Mohamed, S., Farag, M., Ramadan, M. (2018) Origanum vulgare L. essential oil as a potential anti-acne topical nanoemulsion- in vitro and in vivo Study. Molecules, 23(9), 2164.
  • Tohidpour, A., Sattari, M., Omidbaigi, R., Yadegar, A., Nazemi, J. (2010). Antibacterial effect of essential oils from two medicinal plants against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine, 17(2): 142-145.
  • Vilela, G.R., de Almeida, G.S., D'Arce, M.A.B.R., Moraes, M.H.D., Brito, J.O, da Silva, M.F.D.G, da Gloria, EM. (2009) Activity of essential oil and its major compound, 1, 8-cineole, from Eucalyptus globulus Labill., against the storage fungi Aspergillus flavus Link and Aspergillus parasiticus Speare. Journal of Stored Products, 45 (2), 108-111.
  • Vieira, M., Bessa, L.J., Martins, M.R., Arantes, S., Teixeira, A.P., Mendes, A., Belo, A.D. (2017) Chemical composition, antibacterial, antibiofilm and synergistic properties of essential oils from Eucalyptus globulus Labill. and seven Mediterranean aromatic plants. Chemistry & Biodiversity 14(6), e1700006.
  • Wannes, W.A., Mhamdi, B., Sriti, J., Jemia, M.B., Ouchikh, O., Hamdaoui, G., Marzouk, B. (2010) Antioxidant activities of the essential oils and methanol extracts from myrtle (Myrtus communis var. italica L.) leaf, stem and flower. Food and Chemical Toxicologyi 48(5), 1362-1370.
  • Wei, A., Shibamoto, T. (2012). Antioxidant/lipoxygenase inhibitory activities and chemical compositions of selected essential oils. Journal of Agriculture and Food Chemistry, 58(12), 7218-7225.

Year 2020, Volume: 7 Issue: 3, 1 - 11, 07.09.2020

Gamze Göger Nursenem Karaca Betül Büyükkılıç Betül Demirci Fatih Demirci

Abstract

Project Number

AUBAP: 1301S005

References

  • Abascal, K., Yarnell, E (2002).Herbs and drug resistance: Potential of botanical in drug-resistant microbes, Alternive of Complementary Therapies, 8, 237-241.
  • Anonymous (2008). Determination of essential oils in herbal drugs, European Pharmacopoeia 6.0-2.8.12. European Council, Strasbourg, pp. 251
  • Akolade, J.O., Olajide, O.O., Afolayan, M.O., Akande, S.A., Idowu, D.I., Orishadipe, A.T. (2012) Chemical composition, antioxidant and cytotoxic effects of Eucalyptus globulus grown in north-central Nigeria. Journal of Natural Product and Plant Resources. 2(1), 1-8.
  • Athikomkulchai, S., Watthanachaiyingcharoen, R., Tunvichien, S., Vayumhasuwan, P., Karnsomkiet, P., Sae-Jong, P., Ruangrungsi, N. (2008). The development of anti-acne products from Eucalyptus globulus and Psidium Guajava oil. Journal of Health Researchi 22(3), 109-113.
  • Babar, A., Naser, A., Saiba, S., Aftab, A., Shah, Alam, K., Firoz, A. (2015). Essential oils used in aromatherapy: A systemic review. Asian Pacific Journal of Tropical Biomedicine, 5(8), 601-611.
  • Bachir, R.G., Benali, M. (2012). Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pacific Journal of Tropical Biomedicine, 2(9): 739-742.
  • Bhatt, D., Sachan, A.K., Jain, S., Barik, R. (2011). Studies on inhibitory effect of Eucalyptus oil on sebaceous glands for the management of acne. Indian Journal of Natural Product Resources, 2 (3): 345-349.
  • Bansod, S., Rai, M. (2008). Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigatus and A. niger. World Journal of Medicine and Medical Science. 3(2), 81-88.
  • Bassole, I.H.N., Juliani, H.R. (2012). Essential oils in combination and their antimicrobial properties. Molecules, 17 (4), 3989-4006.
  • Baylac, S., Racine, P. (2003). Inhibition of 5-Lipoxygenase by essential oils and other natural fragrant extracts. International Journal of Aromatheraphy, 13(2-3), 38-142.
  • Başer, K.H.C., Buchbauer, G. (2015). Handbook of Essential Oils: Science, Technology, and Applications, second ed., Taylor and Francis, USA.
  • Chouhan, S., Sharma, K., Guleria, S. (2017). Antimicrobial activity of some essential oils-present status and future perspectives. Medicines, 4 (3), 58.
  • Chomnawang, M.T., Surassmo, S., Nukoolkarn, V.S., Gritsanapan, W. (2005). Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. Journal of Ethnopharmacology, 101(1-3), 330-333.
  • Clinical and Laboratory Standards Institute (CLSI). (2006). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, CLSI M7-A7, 940 West Valley Road Wayne, Pennsylvania, USA.
  • Damjanovic-Vratnica, B., Dakov, T., Sukovic, D., Damjanovic, J.. (2001). Antimicrobial effect of essential oil isolated from Eucalyptus globulus Labill. from Montenegro. Czech Journal of Food Sciences, 29(3), 277-284.
  • Das, S., Reynolds, R.V. (2014). Recent advances in acne pathogenesis: implications for therapy. American Journal of Clinical Dermatology, 15 (6), 479-488.
  • Dey, P., Karuna, D.S., Bhakta, T. (2014). Medicinal plants used as anti-acne agents by tribal and non-tribal people of Tripura, India. American Journal of Phytomedicine and Clinical Therapeutics, 2(5), 556-570.
  • Deyno, S., Mtewa, A.G., Abebe, A., Hymete, A., Makonnen, E., Bazira, J., Alele, P.E. (2019). Essential oils as topical anti-infective agents: A systematic review and meta-analysis. Complementary Therapies in Medicine 47, 102224.
  • Dzamic, A.M., Sokovic, M.D., Novakovic, M., Jadranin, M., Ristic, M.S., Tesevic, V., Marin P.D. (2013). Composition, antifungal and antioxidant properties of Hyssopus officinalis L. subsp. pilifer (Pant.) Murb. essential oil and deodorized extracts. Industrial Crops and Product, 51, 401-407.
  • do Rosario Martins, M., Arantes, S., Candeias, F., Tinoco, M.T., Cruz-Morais, J. (2014). Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils. Journal of Ethnopharmacology 151(1), 485-492.
  • Ergin, Ç., Ergin, Ş., Kaleli, İ., Şengül, M., Erdoğan, B.Ş. (2007). Screening of antibiotic resistant Propionibacterium acnes from Acne vulgaris patients: Data from Pamukkale University. Türkderm, 41, 19-21.
  • ESO (2000). The Complete Database of Essential Oils, Boelens Aroma Chemical Information Service, The Netherlands. Ghalem, B.R., Mohamed, B. (2008). Antibacterial activity of leaf essential oils of Eucalyptus globulus and Eucalyptus camaldulensis. African Journal of Pharmacy and Pharmacology, 2(10), 211-215.
  • Harkat-Madouri, L., Asma, B., Madani, K., Said, Z.B.O.S., Rigou, P., Grenier, D., Boulekbache-Makhlouf, L. (2015). Chemical composition, antibacterial and antioxidant activities of essential oil of Eucalyptus globulus from Algeria. Industrial Crops and Product, 78, 148-153.
  • Hammer, K.A. (2015). Treatment of acne with tea tree oil (melaleuca) products: a review of efficacy, tolerability and potential modes of action. International Journal of Antimicrobial Agents, 45(2), 106-110.
  • Joulain, D., Koenig, W.A. (1998). The Atlas of Spectra Data of Sesquiterpene Hydrocarbons, EB-Verlag, Hamburg. Koenig, W.A., Joulain, D., Hochmuth, D.H. (2004). Terpenoids and Related Constituents of Essential Oils, MassFinder 3, Hamburg, Germany.
  • Kumarasamy, Y., Byres, M., Cox, P.J., Jaspars, M., Nahar, L., Sarker, S.D. (2007). Screening seeds of some Scottish plants for free radical scavenging activity. Phytotheraphy Research, 21(7): 615-621.
  • Kuhn, H. (2000). Structural basis for the positional specificity of lipoxygenase, Prostaglandins & other lipid mediators, 62(3), 255-270.
  • Lertsatitthanakorn, P., Taweechaisupapong, S., Aromdee, C., Khunkitti, W. (2006). In vitro bioactivities of essential oils used for acne control. International Jornal of Aromatheraphy, 16 (1), 43-49. Leone, S., Ottani, A., Bertolini, A. (2007). Dual Acting anti-inflammatory drugs. Current Topics in Medicinal Chemistry, 7(3): 265-275.
  • Luangnarumitchai, S., Lamlertthon, S., Tiyaboonchai, W. (2007). Antimicrobial activity of essential oils against five strains of Propionibacterium acnes. Mahidol University Journal of Pharmaceutical Sciences. 34(1-4), 60-64.
  • Luis, A., Duarte, A., Gominho, J., Domingues, F., Duarte, A.P. (2016). Chemical composition, antioxidant, antibacterial and anti-quorum sensing activities of Eucalyptus globulus and Eucalyptus radiata essential oils. Industrial Crops and Product,79, 274-282.
  • Maccioni, A.M., Anchisi, C., Sanna, A., Sardu, C., Dessi, S. (2002). Preservative systems containing essential oils in cosmetic products. International Journal of Cosmetic Sciences, 24(1), 53-59.
  • Mekonnen, A., Yitayew, B., Tesema, A., Taddese, S. (2016). In vitro antimicrobial activity of essential oil of Thymus schimperi, Matricaria chamomilla, Eucalyptus globulus and Rosmarinus officinalis. International Journal of Microbiology, 1-8.
  • McLafferty, F.W., Stauffer, D.B. (1989). The Wiley/NBS Registry of Mass Spectral Data, John Wiley and Sons, New York 1989.
  • Noumi, E., Snoussi, M., Hajlaoui, H., Trabelsi, N., Ksouri, R., Valentin, E., Bakhrouf, A. (2011) Chemical composition, antioxidant and antifungal potential of Melaleuca alternifolia (Tea Tree) and Eucalyptus globulus essential oils against oral Candida species. Journal of Medicinal Plant Research 5(17), 4147-4156.
  • Orafidiya, L., Agbani, E., Oyedele, A., Babalola, O., Onayemi, O. (2002). Preliminary clinical tests on topical preparations of Ocimum gratissimum Linn leaf essential oil for the treatment of acne vulgaris. Clinical Drug Investigtaion, 22(5), 313-319.
  • Orchard, A., Sandasi, M., Kamatou, G., Viljoen, A., Van Vuuren, S. (2017). The in vitro antimicrobial activity and chemometric modelling of 59 commercial essential oils against pathogens of dermatological relevance. Chemistry & Biodiversity, 14(1), e1600218.
  • Orchard, A., Van Vuuren, S.F., Viljoen, A.M., Kamatou, G. (2018). The in vitro antimicrobial evaluation of commercial essential oils and their combinations against acne. International Journal of Cosmetic Sciences, 40 (3), 226-243.
  • Pfaller, M.A., Chaturvedi, V., Diekema, D.J., Ghannoum, M.A., Holliday, N.M., Killian, S.B., Knapp C.C., Messer, S.A., Miskov. A., Ramani, R. (2008). Clinical evaluation of the Sensititre Yeast One colorimetric antifungal panel for antifungal susceptibility testing of the echinocandins anidulafungin, caspofungin, and micafungin. Journal of Clinical Microbiology, 46(7), 2155-2159.
  • Perry, A.L., Lambert, P.A. (2006). Propionibacterium acnes. Letters in Applied Microbiology, 42, 185-188.
  • Sacchetti, G., Maietti, S., Muzzoli, M., Scaglianti, M., Manfredini, S., Radice, M., Bruni, R. (2005). Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chemistry, 91(4), 621-632.
  • Said, Z., Haddadi-Guemghar, H., Boulekbache-Makhlouf, L., Rigou, P., Remini, H., Adjaoud, A., Madani, K. (2016). Essential oils composition, antibacterial and antioxidant activities of hydrodistillated extract of Eucalyptus globulus fruits. Industrial Crops and Product, 89, 167-175.
  • Salari, M., Amine, G., Shirazi, M., Hafezi, R., Mohammadypour, M. (2006). Antibacterial effects of Eucalyptus globulus leaf extract on pathogenic bacteria isolated from specimens of patients with respiratory tract disorders. Clinical Microbiology and Infection, 12(2), 194-196.
  • Serpi, M., Özdemir, Z.Ö., Salman, Y. (2012). Investigation of the antibacterial effects of some plant extracts on Propionibacterium acnes, KSU Journal of Natural Sciences, 15.
  • Silva, J., Abebe, W., Sousa, S.M., Duarte, V.G., Machado, M.I.L. Matos, F.J.A. (2003). Analgesic and anti-inflammatory effects of essential oils of Eucalyptus, Journal of Ethnopharmacology, 89(2-3): 277-283.
  • Sonboli, A., Babakhani, B., Mehrabian, A.R. (2006). Antimicrobial activity of six constituents of essential oil from Salvia. Zeitschrift für Naturforschung C, 61(3-4), 160-164.
  • Taleb, M., Abdeltawab, N., Shamma, R., Abdelgayed, S., Mohamed, S., Farag, M., Ramadan, M. (2018) Origanum vulgare L. essential oil as a potential anti-acne topical nanoemulsion- in vitro and in vivo Study. Molecules, 23(9), 2164.
  • Tohidpour, A., Sattari, M., Omidbaigi, R., Yadegar, A., Nazemi, J. (2010). Antibacterial effect of essential oils from two medicinal plants against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine, 17(2): 142-145.
  • Vilela, G.R., de Almeida, G.S., D'Arce, M.A.B.R., Moraes, M.H.D., Brito, J.O, da Silva, M.F.D.G, da Gloria, EM. (2009) Activity of essential oil and its major compound, 1, 8-cineole, from Eucalyptus globulus Labill., against the storage fungi Aspergillus flavus Link and Aspergillus parasiticus Speare. Journal of Stored Products, 45 (2), 108-111.
  • Vieira, M., Bessa, L.J., Martins, M.R., Arantes, S., Teixeira, A.P., Mendes, A., Belo, A.D. (2017) Chemical composition, antibacterial, antibiofilm and synergistic properties of essential oils from Eucalyptus globulus Labill. and seven Mediterranean aromatic plants. Chemistry & Biodiversity 14(6), e1700006.
  • Wannes, W.A., Mhamdi, B., Sriti, J., Jemia, M.B., Ouchikh, O., Hamdaoui, G., Marzouk, B. (2010) Antioxidant activities of the essential oils and methanol extracts from myrtle (Myrtus communis var. italica L.) leaf, stem and flower. Food and Chemical Toxicologyi 48(5), 1362-1370.
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There are 51 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Articles
Authors

Gamze Göger

Nursenem Karaca

Betül Büyükkılıç 0000-0002-9250-776X

Betül Demirci

Fatih Demirci 0000-0003-1497-3017

Project Number AUBAP: 1301S005
Publication Date September 7, 2020
Published in Issue Year 2020 Volume: 7 Issue: 3

Cite

APA Göger, G., Karaca, N., Büyükkılıç, B., Demirci, B., et al. (2020). In vitro antimicrobial, antioxidant and anti-inflammatory evaluation of Eucalyptus globulus essential oil. Natural Volatiles and Essential Oils, 7(3), 1-11.
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