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Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi

Year 2023, Volume: 12 Issue: 4, 1168 - 1175, 15.10.2023
https://doi.org/10.28948/ngumuh.1276286

Abstract

Farmasötiklerin sucul çevrelere ulaşmasındaki önemli kaynaklardan bir tanesi atıksu arıtma tesisi deşarjlarıdır. Bu çalışmada, Konya kenti kanalizasyon sisteminde bazı analjezik ve anti-enflamatuarların varlığı ve konsantrasyonu, Konya Atıksu Arıtma Tesisin (AAT)’de bu farmasötiklerin giderimi belirlenmiştir. AAT deşarjı ile alıcı ortama deşarj edilen farmasötiklerin oluşturduğu ekotoksikolojik risk balık, Daphnia magna ve alg için değerlendirilmiştir. Kanalizasyon sisteminin 22 farklı noktasından ve ATT giriş-çıkışından alınan örneklerin ekstraksiyonu katı faz ekstraksiyonu ile, farmasötiklerin kalitatif ve kantitatif analizleri ise sıvı kromatografisi kütle spektrometresi (LC-MS/MS) ile gerçekleştirilmiştir. Kanalizasyon sisteminde etodolac 3875 ng/L, diclofenac 119 ng/L, flurbiprofen 247912 ng/L, naproxen 1827 ng/L, paracetamol 7204 ng/L, propyphenazone 2.23 ng/L ortalama konsantrasyonlarında tespit edilmiştir. AAT giriş ve çıkışında ise sırasıyla etodolac 5080 ng/L ve 19688 ng/L, diclofenac 248 ng/L ve 962 ng/L, naproxen 1924 ng/L ve 97.7 ng/L, paracetamol 3286 ng/L ve 109 ng/L, propyphenazone 7.3 ng/L ve 20.9 ng/L ortalama konsantrasyonlarında tespit edilmiştir. AAT’de naproxen, paracetamol farmasötikleri için %90 üzerinde giderim gözlenmiş, diğer farmasötiklerin tesiste giderilemediği görülmüştür. Çıkış atıksuyunda tespit edilen konsantrasyonlar ile yapılan risk değerlendirmesinde risk oranı (RQ) değerleri 4.3x10-5-2.6x10-2 aralığında tespit edilmiştir ve alıcı ortam için önemsiz risk oluşturduğu belirlenmiştir. Buna rağmen, farmasötiklerin alıcı ortamlarda bulunan tek kirletici olmadığı, konvansiyonel ve diğer mikrokirleticilerle bir arada bulunduğu, hepsinin ayrı ayrı toksik etkileri birleştiğinde ciddi çevresel sorunlar oluşturabileceği unutulmamalıdır. Ayrıca, farmasötikler çevresel ortamlarda ve canlı dokularda birikebilir, besin zincirine taşınabilir.

References

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Presence, removal and environmental risk assessment of some analgesic and anti-inflammatory pharmaceuticals in urban wastewater and wastewater treatment plant

Year 2023, Volume: 12 Issue: 4, 1168 - 1175, 15.10.2023
https://doi.org/10.28948/ngumuh.1276286

Abstract

One of the important sources for pharmaceuticals to reach aquatic environments is wastewater treatment plant discharges. In this study, the presence and concentration of some analgesic and anti-inflammatory in the sewage system and the removal of these pharmaceuticals in Konya Wastewater Treatment Plant (WWTP) were determined. Ecological risk posed by pharmaceuticals discharged to the receiving environment with WWTP discharge has been evaluated for fish, Daphnia magna and algae. Extraction of samples taken from 22 different points of the sewage system and WWTP influent and effluent was carried out with a solid phase extraction system. Qualitative and quantitative analyzes of pharmaceuticals were performed by liquid chromatography mass spectrometry (LC-MS/MS). Mean concentrations of etodolac 3875 ng/L, diclofenac 119 ng/L, flurbiprofen 247912 ng/L, naproxen 1827 ng/L, paracetamol 7204 ng/L, propyphenazone 2.23 ng/L were detected in the sewage system. Mean concentrations were detected for etodolac 5080 ng/L, 19688 ng/L, for diclofenac 248 ng/L, 962 ng/L, for naproxen 1924 ng/L, 97 ng/L, for paracetamol 3286 ng/L, 109 ng/L, for propyphenazone 7.30 ng/L, 20.9 ng/L at the influent and effluent of the WWTP, respectively. Over 90% removal was observed for naproxen and paracetamol in the WWTP, and it was observed that other pharmaceuticals could not be removed in the plant. In the risk assessment made with the concentrations detected in the effluent, the RQ values were determined in the range of 4.3x10-5-2.6x10-2 and it poses an insignificant risk for the receiving environment. However, it should be kept in mind that pharmaceuticals are not the only pollutants found in receiving environments, they coexist with conventional and other micropollutants, and when their toxic effects are combined, they can create serious environmental problems. In addition, pharmaceuticals can accumulate in environment and living tissues, enter the food chain.

References

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  • D.J. Son, C.S. Kim, J.W. Park, J.H. Lee, S.H. Lee, S.K. Shin and D.H. Jeong, Fate evaluation of pharmaceuticals in solid and liquid phases at biological process of full-scale municipal wastewater treatment plants. Journal of Water Process Engineering, 46, 102538, 2022. https://doi.org/10.1016/j.jwpe.2021. 102538.
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  • T.B. Veras, A. Luiz Ribeiro de Paiva, M.M.M.B. Duarte, D.C. Napoleão and J.J. da Silva Pereira Cabral, Analysis of the presence of anti-inflammatories drugs in surface water: A case study in Beberibe river - PE, Brazil. Chemosphere, 222, 961–969, 2019. https://doi.org/10.1016/j.chemosphere.201 9.01.167.
  • S. Daouk, N. Chèvre, N. Vernaz, C. Widmer, Y. Daali and S. Fleury-Souverain, Dynamics of active pharmaceutical ingredients loads in a Swiss university hospital wastewaters and prediction of the related environmental risk for the aquatic ecosystems. Science of The Total Environment, 547, 244–253, 2016. https://doi.org/10.1016/j.s citotenv .2015.12.117.
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  • M.J. Gallardo-Altamirano, P. Maza-Márquez, J.M. Peña-Herrera, B. Rodelas, F. Osorio and C. Pozo, Removal of anti-inflammatory/analgesic pharmaceuticals from urban wastewater in a pilot-scale A2O system: Linking performance and microbial population dynamics to operating variables. Science of The Total Environment, 643, 1481–1492, 2018. https://doi.org/10.1016/j.scitotenv.2018.06.284.
  • M. Petrovic, M. Gros and D. Barcelo, Multi-residue analysis of pharmaceuticals in wastewater by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry. Journal of Chromatography A, 1124, 68–81, 2006. https://doi.or g/10.1016/j.chroma.2006.05.024.
  • A. Jurado, E. Vazquez-Sune and E. Pujades, Urban groundwater contamination by nonsteroidal anti-inflammatory drugs. Water, 13, 720, 2021. https://doi .org/10.3390/w13050720.
  • B.M. Sharma, J. Bečanová, M. Scheringer, A. Sharma, G.K. Bharat, P.G. Whitehead, J. Klánová and L. Nizzetto, Health and ecological risk assessment of emerging contaminants (pharmaceuticals, personal care products, and artificial sweeteners) in surface and groundwater (drinking water) in the Ganges River Basin, India. Science of The Total Environment, 646, 1459–1467, 2019. https://doi. org/10.1016/j.scitotenv .2018.07.235.
  • K. Hoshina, S. Horiyama, H. Matsunaga and J. Haginaka, Simultaneous determination of non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography–tandem mass spectrometry using molecularly imprinted polymers as a pretreatment column. Journal of Pharmaceutical and Biomedical Analysis, 55, 5, 916-922, 2011. https://doi.org/10.1016/j.jpba.201 1.03.014.
  • A. Gogoi, P. Mazumder, V.K. Tyagi, G.G.T. Chaminda, A.K. An and M. Kumar, Occurrence and fate of emerging contaminants in water environment: A review. Groundwater for Sustainable Development, 6, 169-180, 2018. https://doi.org/10.1016/j.gsd.2017.12. 009.
  • O.F.S. Khasawneh and P. Palaniandy, Occurrence and removal of pharmaceuticals in wastewater treatment plants. Process Safety and Environmental Protection, 150, 532-556, 2021. https://doi.org/10.1016/j.psep.20 21.04.045.
  • A. Majumder, B. Gupta and A.K. Gupta, Pharmaceutically active compounds in aqueous environment: a status, toxicity and insights of remediation. Environmental Research, 176, 108542, 2019. http://dx.doi.org/10.1016/j.envres.2019.108542.
  • V. Calisto and V.I. Esteves, Psychiatric pharmaceuticals in the environment. Chemosphere, 77, 1257–1274, 2009. https://doi.org/10.1016/j.chemo sphere.2009.09.021.
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There are 42 citations in total.

Details

Primary Language Turkish
Subjects Environmental Engineering
Journal Section Articles
Authors

Arzu Ulvi 0000-0001-7303-1869

Senar Aydın 0000-0002-0960-480X

Mehmet Emin Aydın 0000-0001-6665-198X

Early Pub Date August 16, 2023
Publication Date October 15, 2023
Submission Date April 3, 2023
Acceptance Date July 19, 2023
Published in Issue Year 2023 Volume: 12 Issue: 4

Cite

APA Ulvi, A., Aydın, S., & Aydın, M. E. (2023). Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi, 12(4), 1168-1175. https://doi.org/10.28948/ngumuh.1276286
AMA Ulvi A, Aydın S, Aydın ME. Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi. NOHU J. Eng. Sci. October 2023;12(4):1168-1175. doi:10.28948/ngumuh.1276286
Chicago Ulvi, Arzu, Senar Aydın, and Mehmet Emin Aydın. “Kentsel atıksuda Ve atıksu arıtma Tesisinde Bazı Analjezik Ve Anti-Enflamatuar farmasötiklerinin varlığı, Giderimleri Ve çevresel Risk değerlendirilmesi”. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi 12, no. 4 (October 2023): 1168-75. https://doi.org/10.28948/ngumuh.1276286.
EndNote Ulvi A, Aydın S, Aydın ME (October 1, 2023) Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi 12 4 1168–1175.
IEEE A. Ulvi, S. Aydın, and M. E. Aydın, “Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi”, NOHU J. Eng. Sci., vol. 12, no. 4, pp. 1168–1175, 2023, doi: 10.28948/ngumuh.1276286.
ISNAD Ulvi, Arzu et al. “Kentsel atıksuda Ve atıksu arıtma Tesisinde Bazı Analjezik Ve Anti-Enflamatuar farmasötiklerinin varlığı, Giderimleri Ve çevresel Risk değerlendirilmesi”. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi 12/4 (October 2023), 1168-1175. https://doi.org/10.28948/ngumuh.1276286.
JAMA Ulvi A, Aydın S, Aydın ME. Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi. NOHU J. Eng. Sci. 2023;12:1168–1175.
MLA Ulvi, Arzu et al. “Kentsel atıksuda Ve atıksu arıtma Tesisinde Bazı Analjezik Ve Anti-Enflamatuar farmasötiklerinin varlığı, Giderimleri Ve çevresel Risk değerlendirilmesi”. Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi, vol. 12, no. 4, 2023, pp. 1168-75, doi:10.28948/ngumuh.1276286.
Vancouver Ulvi A, Aydın S, Aydın ME. Kentsel atıksuda ve atıksu arıtma tesisinde bazı analjezik ve anti-enflamatuar farmasötiklerinin varlığı, giderimleri ve çevresel risk değerlendirilmesi. NOHU J. Eng. Sci. 2023;12(4):1168-75.

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