Objective: In the pathophysiology of febrile convulsions, the proportions and functional properties of blood cells change with the effect of increased proinflammatory (IL-1β, IL-6 and TNF-α) cytokines. Peripheral blood leukocyte count, neutrophil/lymphocyte ratio, platelet count, mean platelet count and red blood cell distribution width are important hemogram indices that can be used as inflammation markers. The aim of this study was to evaluate the hemogram parameters between patients followed up with the diagnosis of febrile seizures (simple/complex) and healthy control groups in the same time period. Method: Patients who were diagnosed with simple and complex febrile convulsions between the ages of 6 months and 6 years between August 2019-March 2021 that had hemogram examination within the first 24 hours were evaluated retrospectively as an observational analytical case-control study. Results: Hemoglobin (Hb) (p=0.048), hematocrit (Hct) (p=0.045), platelet (plt) (p=0.001), eosinophil (p=0.001) counts, mean platelet volume (MPV) (p=0.026), MPV/Plt (p=0.006), Plt/MPV (p=0.001), ratios were found to be statistically different between the febrile convulsion group and the control group. Conclusion: Hemoglobin, hematocrit, thrombocyte, MPV, MPV/Plt have been found to be an inflammatory process associated with febrile convulsion. Further prospective studies with larger numbers of participants are now require.
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Amaç: Febril konvülziyon patofizyolojisinde artan proinflamatuar (IL-1β, IL-6 ve TNF-α) sitokinlerin etkisiyle kan hücrelerinin oranları ve fonksiyonel özellikleri değişir. Periferik kandaki lökosit sayısı, nötrofil/lenfosit oranı, trombosit sayısı, ortalama trombosit sayısı ve kırmızı kan hücresi dağılım genişliği inflamasyon belirteçleri olarak kullanılabilecek önemli hemogram indeksleridir. Bu çalışmanın amacı febril konvülziyon tanısı ile takip edilen hastalar ile (basit/komplike) aynı zaman dilimindeki sağlıklı kontrol gruplar arasında hemogram parametrelerinin değerlendirilmesi amaçlanmıştır. Yöntem: Ağustos 2019-Mart 2021 tarihlerinde 6 ay-6 yaş arasında basit ve komplike febril konvülziyon tanısı alan ve ilk 24 saat içinde hemogram tetkiki yapılan hastalar, retrospektif olarak gözlemsel analitik vaka kontrol çalışması olarak değerlendirildi. Bulgular: Febril konvülziyon grubu ile kontrol grubu arasında; hemoglobin (Hb) (p=0.048), hematokrit (Hct) (p=0.045), trombosit (plt) (p=0.001), eozinofil (p=0.001) sayılarının, ortalama trombosit hacmi (MPV) (p=0.026), MPV/Plt (p=0.006), Plt/MPV (p=0.001) oranlarının iki grup arasında istatiksel olarak farklı olduğu saptandı. Sonuç: Hemoglobin, hematokrit, trombosit, MPV, MPV/Plt inflamatuar bir süreç olan febril konvülziyon ile ilişkili bulunmuştur. Konu ile ilgili prospektif daha yüksek katılımlı çalışmalara ihtiyaç bulunmaktadır.
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Primary Language | Turkish |
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Subjects | Health Care Administration |
Journal Section | Articles |
Authors | |
Project Number | yok |
Early Pub Date | December 5, 2023 |
Publication Date | December 18, 2023 |
Submission Date | July 27, 2022 |
Acceptance Date | July 5, 2023 |
Published in Issue | Year 2023 Volume: 16 Issue: 3 |
MEU Journal of Health Sciences Assoc was began to the publishing process in 2008 under the supervision of Assoc. Prof. Gönül Aslan, Editor-in-Chief, and affiliated to Mersin University Institute of Health Sciences. In March 2015, Prof. Dr. Caferi Tayyar Şaşmaz undertook the Editor-in Chief position and since then he has been in charge.
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