Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler

Gaffari Türk

doi:10.12991/mpj.13435

Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler

Year 2013, Volume: 17 Issue: 2, 73 - 92, 24.10.2014

Gaffari Türk

Abstract

Sitotoksik kemoterapi pek çok kanser türünün tedavisinde etkili bir yöntem olmasına
rağmen organizmada sayısız yan etkilere neden olmaktadır. İnfertilite de kemoterapötik ilaçların
hem erkek hem de dişilerde meydana getirdiği en önemli yan etkilerden biridir. Cinsel
isteksizlik, oligo-, azoo-, astenozoo- ve teratozoo-spermi, testiküler yapı, spermatogenesis
ve steroidogenesisteki bozukluklar, gonadotropin düzeylerindeki değişiklikler, sperm DNA
ve kromozomlarındaki hasarlar ve hatta tam sterilite hem kanserli erkekler hem de sağlıklı
deney hayvanlarında bildirilen kemoterapi kaynaklı yan etkilerdir. Kemoterapötiklerin erkeklerdeki
gonadotoksik etkilerinin önlenmesine yönelik hormon ve antioksidan uygulamalar ile
sperma ve germ hücrelerinin dondurularak saklanması gibi birtakım yöntemler kullanılmaktadır.
Bu derlemede kanser tedavisinde yaygın olarak kullanılan kemoterapötiklerin kanserli
ve sağlıklı erkeklerin üreme organ, doku ve hücrelerinde meydana getirdiği yan etkiler ve bu
etkilerin azaltılması veya önlenmesine yönelik koruyucu stratejiler ile ilgili literatür bilgiler
sunulmaktadır.

Keywords

Antioksidan; kemoterapötik; kriyoprezervasyon; oksidatif stres; sperm; testis

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Year 2013, Volume: 17 Issue: 2, 73 - 92, 24.10.2014

Gaffari Türk

Abstract

References

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There are 116 citations in total.

Details

Primary Language	Turkish
Journal Section	Articles
Authors	Gaffari Türk
Publication Date	October 24, 2014
Published in Issue	Year 2013 Volume: 17 Issue: 2

Cite

APA	Türk, G. (2014). Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler. Marmara Pharmaceutical Journal, 17(2), 73-92. https://doi.org/10.12991/mpj.13435
AMA	Türk G. Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler. Marmara Pharm J. October 2014;17(2):73-92. doi:10.12991/mpj.13435
Chicago	Türk, Gaffari. “Kemoterapötiklerin Erkek üreme Sistemi üzerindeki Yan Etkileri Ve Koruyucu Stratejiler”. Marmara Pharmaceutical Journal 17, no. 2 (October 2014): 73-92. https://doi.org/10.12991/mpj.13435.
EndNote	Türk G (October 1, 2014) Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler. Marmara Pharmaceutical Journal 17 2 73–92.
IEEE	G. Türk, “Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler”, Marmara Pharm J, vol. 17, no. 2, pp. 73–92, 2014, doi: 10.12991/mpj.13435.
ISNAD	Türk, Gaffari. “Kemoterapötiklerin Erkek üreme Sistemi üzerindeki Yan Etkileri Ve Koruyucu Stratejiler”. Marmara Pharmaceutical Journal 17/2 (October 2014), 73-92. https://doi.org/10.12991/mpj.13435.
JAMA	Türk G. Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler. Marmara Pharm J. 2014;17:73–92.
MLA	Türk, Gaffari. “Kemoterapötiklerin Erkek üreme Sistemi üzerindeki Yan Etkileri Ve Koruyucu Stratejiler”. Marmara Pharmaceutical Journal, vol. 17, no. 2, 2014, pp. 73-92, doi:10.12991/mpj.13435.
Vancouver	Türk G. Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler. Marmara Pharm J. 2014;17(2):73-92.

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