Research Article
Year 2018,
Volume: 5 Issue: 1, 179 - 190, 01.09.2017
Abstract
Coriandrum sativum L.oil has antibacterial,
antifungal and antimicrobial activity. This
study aims to prepare and characterize chitosan nanoparticles loaded with Coriandrum sativum L., commonly known as coriander oil, using
ionic gelation method and to determine their cytotoxicity in cell culture.
Tripolyphosphate (TPP) was used as a cross-linker in ionic gelation method. The
characterization of the chitosan nanoparticles loaded with coriander (Coriandrum sativum L.) oil was performed
with Zeta-Sizer, Fourier transform Infrared spectrophotometer (FT-IR), scanning
electron microscopy (SEM) and electron dispersive X-ray Spectroscopy (EDS). It
was shown that chitosan nanoparticles loaded with coriander oil have an average
size of 113.5 nm, zeta potential of 16 mV and a polydispersity
index of 0.378. SEM analysis showed that they have spherical
morphology and EDS showed the element composition. Furthermore,
cytotoxicity analysis on L929 fibroblast cells was performed using XTT method
and it was observed that chitosan particles loaded with coriander oil, coriander
oil and empty chitosan nanoparticles did not provoke significant toxicity on
cells.
References
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- 10. Shukla SK, Mishra AK, Arotiba OA, Mamba BB. Chitosan-based nanomaterials: A state-of-the-art review. International journal of biological macromolecules. 2013;59:46-58. 11. Rinaudo M. Chitin and chitosan: properties and applications. Progress in polymer science. 2006;31(7):603-32.
- 12. Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. Journal of controlled release. 2004;100(1):5-28.
- 13. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chemical reviews. 1999;99(11):3181-98.
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- 15. Dima C, Pătraşcu L, Cantaragiu A, Alexe P, Dima Ş. The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules. Food chemistry. 2016;195:39-48.
- 16. Calvo P, Remunan‐Lopez C, Vila‐Jato JL, Alonso M. Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers. Journal of Applied Polymer Science. 1997;63(1):125-32.
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- 18. Kumar MNR. A review of chitin and chitosan applications. Reactive and functional polymers. 2000;46(1):1-27.
- 19. López-García J, Lehocký M, Humpolíček P, Sáha P. HaCaT keratinocytes response on antimicrobial atelocollagen substrates: extent of cytotoxicity, cell viability and proliferation. Journal of functional biomaterials. 2014;5(2):43-57.
- 20. ISO. 10993-5:2009 Biological Evaluation of Medical Devices. Part 5: Tests for In Vitro Cytotoxicity. International Organization for Standardization. Geneva, Switzerland. 2009.
Year 2018,
Volume: 5 Issue: 1, 179 - 190, 01.09.2017
Abstract
References
- 1. Laribi B, Kouki K, M'Hamdi M, Bettaieb T. Coriander (Coriandrum sativum L.) and its bioactive constituents. Fitoterapia. 2015;103:9-26.
- 2. Diederichsen A. Coriander: Coriandrum Sativum L: Bioversity International; 1996.
- 3. Lawrence BM. Progress in essential oils. Perfumer & flavorist. 1992;17(5):131-46.
- 4. Padmaa M. Coriandrum sativum linn: a review. Pharmacol online Newsl. 2009;3:561-73.
- 5. Matasyoh J, Maiyo Z, Ngure R, Chepkorir R. Chemical composition and antimicrobial activity of the essential oil of Coriandrum sativum. Food Chemistry. 2009;113(2):526-9.
- 6. Chang M-Y, Shen Y-L. Linalool exhibits cytotoxic effects by activating antitumor immunity. Molecules. 2014;19(5):6694-706.
- 7. Asgarpanah J, Kazemivash N. Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L. African Journal of Pharmacy and Pharmacology. 2012;6(31):2340-5.
- 8. Stashenko EE, Puertas MA, Martínez JR. SPME determination of volatile aldehydes for evaluation of in-vitro antioxidant activity. Analytical and bioanalytical chemistry. 2002;373(1):70-4.
- 9. Donsì F, Annunziata M, Sessa M, Ferrari G. Nanoencapsulation of essential oils to enhance their antimicrobial activity in foods. LWT-Food Science and Technology. 2011;44(9):1908-14.
- 10. Shukla SK, Mishra AK, Arotiba OA, Mamba BB. Chitosan-based nanomaterials: A state-of-the-art review. International journal of biological macromolecules. 2013;59:46-58. 11. Rinaudo M. Chitin and chitosan: properties and applications. Progress in polymer science. 2006;31(7):603-32.
- 12. Agnihotri SA, Mallikarjuna NN, Aminabhavi TM. Recent advances on chitosan-based micro-and nanoparticles in drug delivery. Journal of controlled release. 2004;100(1):5-28.
- 13. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chemical reviews. 1999;99(11):3181-98.
- 14. Duman F, Kaya M. Crayfish chitosan for microencapsulation of coriander (Coriandrum sativum L.) essential oil. International Journal of Biological Macromolecules. 2016;92:125-33.
- 15. Dima C, Pătraşcu L, Cantaragiu A, Alexe P, Dima Ş. The kinetics of the swelling process and the release mechanisms of Coriandrum sativum L. essential oil from chitosan/alginate/inulin microcapsules. Food chemistry. 2016;195:39-48.
- 16. Calvo P, Remunan‐Lopez C, Vila‐Jato JL, Alonso M. Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers. Journal of Applied Polymer Science. 1997;63(1):125-32.
- 17 .Reed SJB, Reed SJB. Electron microprobe analysis: Cambridge University Press Cambridge; 1975.
- 18. Kumar MNR. A review of chitin and chitosan applications. Reactive and functional polymers. 2000;46(1):1-27.
- 19. López-García J, Lehocký M, Humpolíček P, Sáha P. HaCaT keratinocytes response on antimicrobial atelocollagen substrates: extent of cytotoxicity, cell viability and proliferation. Journal of functional biomaterials. 2014;5(2):43-57.
- 20. ISO. 10993-5:2009 Biological Evaluation of Medical Devices. Part 5: Tests for In Vitro Cytotoxicity. International Organization for Standardization. Geneva, Switzerland. 2009.
There are 19 citations in total.
Details
| Subjects | Engineering, Chemical Engineering |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | September 1, 2017 |
| Submission Date | July 20, 2017 |
| Acceptance Date | December 1, 2017 |
| Published in Issue | Year 2018 Volume: 5 Issue: 1 |
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