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The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects

Year 2016, Volume: 46 Issue: 2, 71 - 78, 26.12.2016

Burcu Şen Sonja Kessler Bahar Gürdal Alexandra Kiemer Afife Mat

Abstract

The genus Erica comprises five species (E. arborea, E. bocquetii, E. manipuliflora, E. sicula, E. spiculifolia), in Turkey. In traditional Turkish medicine, the aerial parts of E. arborea and E. manipuliflora are used as diuretic and astringent and in the treatment of urinary infections. Additionally, the decoction of E. manipuliflora is used as weight-loss medicine, diuretic and in the treatment of diabetes, in Mugla (Turkey) and Western Mediterrenean Region in Turkey. This present study aimed to determine the cytotoxicity potentials of different extracts from this species and compare the cytotoxicity between its flowering and fruiting periods.

Keywords

Erica manipuliflora cytotoxicity HepG2 HUVEC

References

  • Ballester A, Verwey A, Ovbreem JC (1975) 2-hydroxyphenylacetic acid and 2,4-dihydroxyphenyl acetonitrile from Erica scoparia. Phytochem., 14: 1667-1668.
  • Başer KHC, Honda G, Miki W (1986) Herb Drugs and Herbalists in Turkey. Institute for the Study of Languages and Cultures of Asia and Africa, Tokyo: Studia Culturae Islamicae. 27.
  • Baytop T. (1999). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün). Nobel Tip Kitabevleri Ltd., Istanbul. Bennini B, Chulia AJ, Kaouadji M, Delage C (1993) Phytochemistry of the Ericaceae 4. (2R,3R) dihydroflavonol aglycone and glycosides from Erica cinerea. Phytochem., 33: 1233-1236.
  • Carballeira A (1982) Phytotoxicity of Erica australis L. from heathland soils. An. Edafol. Agrobiol., 41: 2287-2294.
  • Chulia A, Benini B, Kaouadji M, Allais DP, Delage C (1995) Two flavonol conjugates from Erica cinerea. J. Nat. Prod., 58: 560-563.
  • Crowden RK, Jarman JR (1976) Anthocyanins in the genus Erica. Phytochem., 15: 1796-1797.
  • Davis PH (ed.) (1978) Flora of Turkey and the East Aegean Islands. Vol. 6, Edinburgh University Press, Edinburgh.
  • Diesel B, Ripoche N, Risch RT, Tierling S, Walter J, Kiemer AK (2011) Inflammation induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island. Innate Immun., 18: 112-123.
  • Fakir H, Korkmaz M, Güller B (2009) Medicinal plant diversity of western mediterrenean region in Turkey. JAEBS, 3: 33-43.
  • Güner A, Aslan S, Ekim T, Vural M, Babaç MT (eds.)(2012) Türkiye Bitkileri Listesi (Damarlı Bitkiler). Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını.
  • Güvenç A (2007) Türkiye’de Yetişen Erica L. Türlerinin Antioksidan Etkilerinin Tayini. Ankara Üniversitesi Bilimsel Araştırma Projesi - Proje No: 2003 08 03 044. Güvenç A, Kendir G, Eken A, Aydın A (2007) Evaluation of Inorganic Compounds of Erica L. Species (Ericaceae) Native to Turkey. FABAD J. Pharm. Sci., 32: 121-125.
  • Kessler SM, Pokorny J, Zimmer V, Laggai S, Lammert F, Bohle RM, Kiemer AK (2013) IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling. Am. J. Physiol. Gastrointest. Liver Physiol., 304: 328-336.
  • Kıvçak B, Fafal-Erdoğan T, Gönenç T, Pabuçcuoğlu A, Oran E, Kahraman F, Öztürk T (2013) Antioxidant, Antimicrobial and Cytotoxic Activities of Erica bocquetii P. F. Stevens and Erica arborea L. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi / Gümüşhane University Journal of Health Sciences, 2: 52-65.
  • Kiemer AK, Weber NC, Fürst R, Bildner N, Kulhanek-Heinze S, Vollmar AM (2002) Inhibition of p38 MAPK Activation via Induction of MKP-1 Atrial Natriuretic Peptide Reduces TNF-–Induced Actin Polymerization and Endothelial Permeability. Circ. Res., 90: 874-881.
  • Küpeli Akkol E, Yeşilada E, Güvenç A (2008) Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. J. Ethnopharmacol., 116: 251-257.
  • Martin-Cordero C, Reyes M, Ayuso MJ, Toro MV (2001) Cytotoxic triterpenoids from Erica andevalensis. Z. Naturforsch. C., 56: 45-48.
  • Mendez J (1978) Isofraxidin in Erica flowers. Phytochem., 17: 820.
  • Mosmann T (1983) Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J. Immunol. Methods, 65: 55-63.
  • Oddo LP, Piazza MG, Pulcini P (1999) Invertase activity in honey. Apidologie, 30: 57-65.
  • Reyes Ruiz M, Martin-Cordero C, Ayuso Gonzalez MJ, Toro Sainz MV, Alarcon de la Lastra C (1996) Antiulcer activity in rats by flavonoids of Erica andevalensis Cabezudo-Rivera. Phytother. Res., 10: 300-303.
  • Sağıroglu M, Dalgıc S, Toksoy S (2013) Medicinal plants used in Dalaman (Muğla), Turkey. J. Med. Plant Res., 7: 2053-2066.
  • Toro Sainz MV, Garcia Gimenez MD, Pascual Martinez M (1987) Isolation and identification of phenol acids from Erica andevalensis Cabezudo-Ribera: their contribution to an antibacterial activity. Ann. Pharm. Françaises, 45: 401-407.
  • Tuzlacı E, Eryaşar Aymaz P (2001) Turkish folk medicinal plants, Part IV: Gönen (Balıkesir). Fitoterapia, 72: 323-343.
  • Tzitsa E, Tzakou O, Loukis A (2000). Volatile constituents of Erica manipuliflora Salisb. from Greece. J. Essent. Oil Res., 12: 67-68.
  • Vieitez E, Ballester A (1972) Phenolic and coumaric components in Erica cinerea. Anales Inst. Bot. Cavanilles, 29: 129-142.
  • Villareal MO, Han J, Matsuyama K, Sekii Y, Smaoui A, Shigemori H, Isoda H (2013) Lupenone from Erica multiflora leaf extract stimulates melanogenesis in B16 murine melanoma cells through the inhibition of ERK1/2 activation. Planta Med., 79: 236-243.

Year 2016, Volume: 46 Issue: 2, 71 - 78, 26.12.2016

Burcu Şen Sonja Kessler Bahar Gürdal Alexandra Kiemer Afife Mat

Abstract

References

  • Ballester A, Verwey A, Ovbreem JC (1975) 2-hydroxyphenylacetic acid and 2,4-dihydroxyphenyl acetonitrile from Erica scoparia. Phytochem., 14: 1667-1668.
  • Başer KHC, Honda G, Miki W (1986) Herb Drugs and Herbalists in Turkey. Institute for the Study of Languages and Cultures of Asia and Africa, Tokyo: Studia Culturae Islamicae. 27.
  • Baytop T. (1999). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün). Nobel Tip Kitabevleri Ltd., Istanbul. Bennini B, Chulia AJ, Kaouadji M, Delage C (1993) Phytochemistry of the Ericaceae 4. (2R,3R) dihydroflavonol aglycone and glycosides from Erica cinerea. Phytochem., 33: 1233-1236.
  • Carballeira A (1982) Phytotoxicity of Erica australis L. from heathland soils. An. Edafol. Agrobiol., 41: 2287-2294.
  • Chulia A, Benini B, Kaouadji M, Allais DP, Delage C (1995) Two flavonol conjugates from Erica cinerea. J. Nat. Prod., 58: 560-563.
  • Crowden RK, Jarman JR (1976) Anthocyanins in the genus Erica. Phytochem., 15: 1796-1797.
  • Davis PH (ed.) (1978) Flora of Turkey and the East Aegean Islands. Vol. 6, Edinburgh University Press, Edinburgh.
  • Diesel B, Ripoche N, Risch RT, Tierling S, Walter J, Kiemer AK (2011) Inflammation induced up-regulation of TLR2 expression in human endothelial cells is independent of differential methylation in the TLR2 promoter CpG island. Innate Immun., 18: 112-123.
  • Fakir H, Korkmaz M, Güller B (2009) Medicinal plant diversity of western mediterrenean region in Turkey. JAEBS, 3: 33-43.
  • Güner A, Aslan S, Ekim T, Vural M, Babaç MT (eds.)(2012) Türkiye Bitkileri Listesi (Damarlı Bitkiler). Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını.
  • Güvenç A (2007) Türkiye’de Yetişen Erica L. Türlerinin Antioksidan Etkilerinin Tayini. Ankara Üniversitesi Bilimsel Araştırma Projesi - Proje No: 2003 08 03 044. Güvenç A, Kendir G, Eken A, Aydın A (2007) Evaluation of Inorganic Compounds of Erica L. Species (Ericaceae) Native to Turkey. FABAD J. Pharm. Sci., 32: 121-125.
  • Kessler SM, Pokorny J, Zimmer V, Laggai S, Lammert F, Bohle RM, Kiemer AK (2013) IGF2 mRNA binding protein p62/IMP2-2 in hepatocellular carcinoma: antiapoptotic action is independent of IGF2/PI3K signaling. Am. J. Physiol. Gastrointest. Liver Physiol., 304: 328-336.
  • Kıvçak B, Fafal-Erdoğan T, Gönenç T, Pabuçcuoğlu A, Oran E, Kahraman F, Öztürk T (2013) Antioxidant, Antimicrobial and Cytotoxic Activities of Erica bocquetii P. F. Stevens and Erica arborea L. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi / Gümüşhane University Journal of Health Sciences, 2: 52-65.
  • Kiemer AK, Weber NC, Fürst R, Bildner N, Kulhanek-Heinze S, Vollmar AM (2002) Inhibition of p38 MAPK Activation via Induction of MKP-1 Atrial Natriuretic Peptide Reduces TNF-–Induced Actin Polymerization and Endothelial Permeability. Circ. Res., 90: 874-881.
  • Küpeli Akkol E, Yeşilada E, Güvenç A (2008) Valuation of anti-inflammatory and antinociceptive activities of Erica species native to Turkey. J. Ethnopharmacol., 116: 251-257.
  • Martin-Cordero C, Reyes M, Ayuso MJ, Toro MV (2001) Cytotoxic triterpenoids from Erica andevalensis. Z. Naturforsch. C., 56: 45-48.
  • Mendez J (1978) Isofraxidin in Erica flowers. Phytochem., 17: 820.
  • Mosmann T (1983) Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J. Immunol. Methods, 65: 55-63.
  • Oddo LP, Piazza MG, Pulcini P (1999) Invertase activity in honey. Apidologie, 30: 57-65.
  • Reyes Ruiz M, Martin-Cordero C, Ayuso Gonzalez MJ, Toro Sainz MV, Alarcon de la Lastra C (1996) Antiulcer activity in rats by flavonoids of Erica andevalensis Cabezudo-Rivera. Phytother. Res., 10: 300-303.
  • Sağıroglu M, Dalgıc S, Toksoy S (2013) Medicinal plants used in Dalaman (Muğla), Turkey. J. Med. Plant Res., 7: 2053-2066.
  • Toro Sainz MV, Garcia Gimenez MD, Pascual Martinez M (1987) Isolation and identification of phenol acids from Erica andevalensis Cabezudo-Ribera: their contribution to an antibacterial activity. Ann. Pharm. Françaises, 45: 401-407.
  • Tuzlacı E, Eryaşar Aymaz P (2001) Turkish folk medicinal plants, Part IV: Gönen (Balıkesir). Fitoterapia, 72: 323-343.
  • Tzitsa E, Tzakou O, Loukis A (2000). Volatile constituents of Erica manipuliflora Salisb. from Greece. J. Essent. Oil Res., 12: 67-68.
  • Vieitez E, Ballester A (1972) Phenolic and coumaric components in Erica cinerea. Anales Inst. Bot. Cavanilles, 29: 129-142.
  • Villareal MO, Han J, Matsuyama K, Sekii Y, Smaoui A, Shigemori H, Isoda H (2013) Lupenone from Erica multiflora leaf extract stimulates melanogenesis in B16 murine melanoma cells through the inhibition of ERK1/2 activation. Planta Med., 79: 236-243.
There are 26 citations in total.

Details

Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Araştırma Makalesi
Authors

Burcu Şen

Sonja Kessler This is me

Bahar Gürdal

Alexandra Kiemer This is me

Afife Mat This is me

Publication Date December 26, 2016
Published in Issue Year 2016 Volume: 46 Issue: 2

Cite

APA Şen, B., Kessler, S., Gürdal, B., Kiemer, A., et al. (2016). The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. Journal of Faculty of Pharmacy of Istanbul University, 46(2), 71-78.
AMA Şen B, Kessler S, Gürdal B, Kiemer A, Mat A. The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. Journal of Faculty of Pharmacy of Istanbul University. December 2016;46(2):71-78.
Chicago Şen, Burcu, Sonja Kessler, Bahar Gürdal, Alexandra Kiemer, and Afife Mat. “The Difference Between the Extracts of Erica Manipuliflora in Flowering and Fruiting Periods in Terms of the Cytotoxic Effects”. Journal of Faculty of Pharmacy of Istanbul University 46, no. 2 (December 2016): 71-78.
EndNote Şen B, Kessler S, Gürdal B, Kiemer A, Mat A (December 1, 2016) The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. Journal of Faculty of Pharmacy of Istanbul University 46 2 71–78.
IEEE B. Şen, S. Kessler, B. Gürdal, A. Kiemer, and A. Mat, “The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects”, Journal of Faculty of Pharmacy of Istanbul University, vol. 46, no. 2, pp. 71–78, 2016.
ISNAD Şen, Burcu et al. “The Difference Between the Extracts of Erica Manipuliflora in Flowering and Fruiting Periods in Terms of the Cytotoxic Effects”. Journal of Faculty of Pharmacy of Istanbul University 46/2 (December 2016), 71-78.
JAMA Şen B, Kessler S, Gürdal B, Kiemer A, Mat A. The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. Journal of Faculty of Pharmacy of Istanbul University. 2016;46:71–78.
MLA Şen, Burcu et al. “The Difference Between the Extracts of Erica Manipuliflora in Flowering and Fruiting Periods in Terms of the Cytotoxic Effects”. Journal of Faculty of Pharmacy of Istanbul University, vol. 46, no. 2, 2016, pp. 71-78.
Vancouver Şen B, Kessler S, Gürdal B, Kiemer A, Mat A. The difference between the extracts of Erica manipuliflora in flowering and fruiting periods in terms of the cytotoxic effects. Journal of Faculty of Pharmacy of Istanbul University. 2016;46(2):71-8.
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