Research Article
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The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity

Year 2022, Volume 5, Issue 2, 110 - 116, 01.04.2022
https://doi.org/10.3153/AR22010

Abstract

Today, fungicide toxicity is quite common in aquatic ecosystems, and this situation adversely affects marine organisms. For this reason, it is essential to determine the effects of fungicides on aquatic organisms and to try to prevent organisms from being exposed to these toxic chemicals. In this study, changes in cholinergic system enzymes and (malondialdehyde) MDA levels as a result of exposure to acute fungicide toxicity in Van fish (Alburnus tarichi, Güldenstädt 1814) were investigated. Brain tissue was taken from Van fish exposed to 2.5 M Tebuconazole used in agriculture by sampling at 24, 48, 72, and 96 hours. Brain tissue acetylcholinesterase (AChE), butyrylcholinesterase (BChE) activities, and MDA levels were measured in this context. In the study, AChE (0.965± 0.03, 0.575±0.01) and BChE (0.421±0.02, 0,291±0.01) activities decreased in Van fish brain tissue due to exposure to Tebuconazole, but MDA (0.099±0.01, 0.192±0.01) level increased (p < 0.05).

References

  • Akdeniz, Ö. (2019). Asetilkolinesteraz ve bütirilkolinesteraz enzimleri üzerinde bazı pestisitlerin etkilerinin incelenmesi. Ağrı: İbrahim İbrahim Çeçen Üniversitesi, Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, Ağrı, Türkiye.
  • Alak, G., Yeltekin, A.Ç., Özgeriş, B.F., Parlak, V., Uçar, A., Keleş, M.S., Atamanalp, M. (2019a). Therapeutic effect of N- acetyl cysteine as an antioxidant on rainbow trout's brain in cypermethrin toxicity. Chemosphere, 221, 30-36. https://doi.org/10.1016/j.chemosphere.2018.12.196
  • Alak, G., Ucar, A., Yeltekin, A. Ç., Parlak, V. Nardemir, G., Kızılkaya, M., Taş, İ. H., Yılgın, M., Atamanalp, M., Topal, A., Kocaman, E.M., Yanık, T. (2019b). Neurophysiological responses in the brain tissues of rainbow trout (Oncorhynchus mykiss) treated with bio-pesticide, Drug and Chemical Toxicology, 42(2), 203-209. https://doi.org/10.1080/01480545.2018.1526180
  • Atamanalp, M., Parlak, V., Betül Özgeriş, F., Yeltekin, A.Ç., Ucar, A. Keleş, M.S., Alak, G. (2021). Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish. Toxicology Mechanisms and Methods, 31(3), 224-234. https://doi.org/10.1080/15376516.2021.1871794
  • Batta, Y.A. (2005). Control of the lesser grain borer (Rhyzopertha dominica (F.), Coleoptera: Bostrichidae) by treatments with residual formulations of Metarhizium anisopliae (Metschnikoff) Sorokin (Deuteromycotina: Hyphomycetes). Journal of Stored Products Research. 41(2), 221-229. https://doi.org/10.1016/j.jspr.2004.03.007
  • Bayer Crop Science Limited, (2005). Enviromental information sheet folicur® MAPP number 11278. CPA Guidance Notes version3.©EIS.
  • Devasagayam, T.P.A., Boloor, K.K., Ramsarma, T. (2003). Methods for estimating lipid peroxidation: Analysis of merits and demerits (minireview). Indian Journal of Biochemistry and Biophysics, 40(5), 300-308.
  • Das, S.K., Maji, S. Wechman, S.L., Bhoopathi, P., Pradhan A.K., Talukdar S., Sarkar, D., Landry, J., Guo, C. Wang, X.Y., Cavenee W.K., Emdad, L., Fisher, P.B. (2020). MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis, Pharmacological Research, 155, 104695. https://doi.org/10.1016/j.phrs.2020.104695
  • Ellman, G.L., Courtney, K.D., Andres, V. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacology., 7, 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
  • Fetoui, H., Makni, M., Garoui, E.M., Zegha, N. (2010). Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid. Experimental and Toxicologic Pathology, 62(6), 593-599. https://doi.org/10.1016/j.etp.2009.08.004
  • Gao, B., Saralamba, S., Lubell, Y., White, L.J., Dondorp, A.M., Aguas, R. (2020). Determinants of MDA impact and designing MDAs towards malaria elimination. Epidemiology And Global Health, 9, e51773. https://doi.org/10.7554/eLife.51773
  • Glusczak, L., Miron, D.D.S., Moraes, B.S., Simões, R.R., Schetinger, M.R.C., Vânia, V.M., Loro, L., (2007). Acute effects of glyphosate herbicide on metabolic and enzymatic parameters of silver cafish (Rhamdia Quelen). Comparative Biochemistru Biochemistrand Physiology Part C., 146, 519-524. https://doi.org/10.1016/j.cbpc.2007.06.004
  • Lutnicka, H., Bojarskı, B., Ludwıkowska, A., Wroñska, D., Kamıñska, T., Szczygıe £, J., Troszok, A., Szabelan, K., Formıckı, G. (2016). Hematological alterations as a response to exposure to selected fungicides in common carp (Cyprinus carpio L.). Folia Biologica (Kraków), 64(4), 235-244. https://doi.org/10.3409/fb64_4.235
  • Mis, L., Comba, B., Uslu, S. and Yeltekin, A. Ç. (2018). Effect of wheatgrass on DNA damage, oxidative stress index and histological findings in diabetic rats. International Journal of Morphology, 36(4), 1235-1240. https://doi.org/10.4067/S0717-95022018000401235
  • Nasr, I.N., Ahmed, N.S., Al-Maz, M.M. (2003). Effect of boiling and some environmental factors on residues behaviour of penconazole fungicide on vine leaves. Annals of Agricultural Science (Cairo), 48, 365-372.
  • Nong, Q.Y., Liu, Y.A., Qin, L.T., Liu, M. Mo, L.Y., Liang, Y.P., Zeng H.H. (2020). Toxic mechanism of three azole fungicides and their mixture to green alga Chlorella pyrenoidosa, Chemosphere, 262, 127793. https://doi.org/10.1016/j.chemosphere.2020.127793
  • Placer, Z.A., Cushman, L., Johnson, B.C. (1966). Estimation of products of lipid peroxidation (Malonyl dialdehyde) in biological fluids. Analytical Biochemistry, 16(2), 359-364. https://doi.org/10.1016/0003-2697(66)90167-9
  • Parvez, S., Raisuddin, S. (2005). Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch), Environmental Toxicology and Pharmacology, 20(1), 112-117. https://doi.org/10.1016/j.etap.2004.11.002
  • Rafael, D.S., Azevedo, Kivia, V.G., Falcão, Caio R.D. Assis, Regildo M.G. Martins, Marlyete, C. Araújo, Gilvan T. Yogui, Jorge L. Neves, Gustavo M. Seabra, Maria B.S. Maia, Ian P.G. Amaral, Ana C.R. Leite, Ranilson Bezerra S. (2021). Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase, Chemosphere, 263, 128029. https://doi.org/10.1016/j.chemosphere.2020.128029
  • Ramírez-Santana, M., Zúñiga-Venegas, L., Corral, S., Roeleveld, N., Groenewoud, H., Koosvan der Veldenf Paul, T.J., Floria Pancetti, S. (2020). Association between cholinesterase's inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile. Environmental Research. 186, 109539. https://doi.org/10.1016/j.envres.2020.109539
  • Rossi, G. P., Sanga, V., Barton M. (2020). Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. Medicine, 9, e57278. https://doi.org/10.7554/eLife.57278
  • Santana, M.S., Sandrini-Neto, L., Di Domenico, M., Prodocimo, M.M. (2021). Pesticide effects on fish cholinesterase variability and mean activity: A meta-analytic review. Science of the Total Environment, 757, 143829. https://doi.org/10.1016/j.scitotenv.2020.143829
  • Sepici-Dincel, A., Benli, A.C., Selvi, M., Sarıkaya, R., Sahin, D., Ozkul, A., Erkoc, F., (2009). Sublethal cyfluthrin toxicity to carp (Cyprinus Carpio L.) Fingerlings: Biochemical, hematological, histopathological alterations. Ecotoxicology and Environmental Safety, 72, 1433-1439. https://doi.org/10.1016/j.ecoenv.2009.01.008
  • Sequeira-Mendes, J., Díaz-Uriarte, R., Apedaile, A., Huntley, D., Brockdorff, N. (2009). Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells. PLOS Genetics 5(4), e1000446. https://doi.org/10.1371/journal.pgen.1000446
  • Siek, M. M., Paszko, T. (2021). Fate of Tebuconazole in Polish Mineral Soils – Results of Simulations with FOCUS PELMO. Journal of Ecological Engineering, 22(11), 131-141. https://doi.org/10.12911/22998993/142936
  • Souders, C. L., Perez-Rodriguez, V., El Ahmadie, N., Zhang, X., Tischuk, C., Martyniuk, C.J. (2020). Investigation into the sub-lethal effects of the triazole fungicide triticonazole in zebrafish (Danio rerio) embryos/larvae. Environmental Toxicology, 35, 254-267. https://doi.org/10.1002/tox.22862
  • Uçar, A., Özgeriş, F.B., Parlak, V., Yeltekin, A.Ç., Kocaman, E.M., Alak, G., Atamanalp M. (2021). Neurotoxic responses of rainbow trout (Oncorhynchus mykiss) exposed to fipronil: multi-biomarker approach to illuminate the mechanism in brain. Drug and Chemical Toxicology, https://doi.org/10.1080/01480545.2021.1908751 Yeltekin, A.Ç., Oğuz, A.R., İribuğday, F., Ergöz, B. (2018). Investigation of some metal levels in different tissue dependent on the age variation of Van Fish (Alburnus tarichi, Güldenstädt 1814). Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 14(2), 89-101. https://doi.org/10.22392/egirdir.348088
  • Yeltekin AÇ, Oguz AR, Kankaya E, Ozok N, Guneş, I. (2020). Hematological and biochemical response in the blood of Alburnus Tarichi (Actinopterygii: Cypriniformes: Cyprinidae) exposed to tebuconazole. Acta Ichthyologica Et Piscatoria. 50(4), 373-379. https://doi.org/10.3750/AIEP/02931

Year 2022, Volume 5, Issue 2, 110 - 116, 01.04.2022
https://doi.org/10.3153/AR22010

Abstract

References

  • Akdeniz, Ö. (2019). Asetilkolinesteraz ve bütirilkolinesteraz enzimleri üzerinde bazı pestisitlerin etkilerinin incelenmesi. Ağrı: İbrahim İbrahim Çeçen Üniversitesi, Fen Bilimleri Enstitüsü, Yüksek Lisans Tezi, Ağrı, Türkiye.
  • Alak, G., Yeltekin, A.Ç., Özgeriş, B.F., Parlak, V., Uçar, A., Keleş, M.S., Atamanalp, M. (2019a). Therapeutic effect of N- acetyl cysteine as an antioxidant on rainbow trout's brain in cypermethrin toxicity. Chemosphere, 221, 30-36. https://doi.org/10.1016/j.chemosphere.2018.12.196
  • Alak, G., Ucar, A., Yeltekin, A. Ç., Parlak, V. Nardemir, G., Kızılkaya, M., Taş, İ. H., Yılgın, M., Atamanalp, M., Topal, A., Kocaman, E.M., Yanık, T. (2019b). Neurophysiological responses in the brain tissues of rainbow trout (Oncorhynchus mykiss) treated with bio-pesticide, Drug and Chemical Toxicology, 42(2), 203-209. https://doi.org/10.1080/01480545.2018.1526180
  • Atamanalp, M., Parlak, V., Betül Özgeriş, F., Yeltekin, A.Ç., Ucar, A. Keleş, M.S., Alak, G. (2021). Treatment of oxidative stress, apoptosis, and DNA injury with N-acetylcysteine at simulative pesticide toxicity in fish. Toxicology Mechanisms and Methods, 31(3), 224-234. https://doi.org/10.1080/15376516.2021.1871794
  • Batta, Y.A. (2005). Control of the lesser grain borer (Rhyzopertha dominica (F.), Coleoptera: Bostrichidae) by treatments with residual formulations of Metarhizium anisopliae (Metschnikoff) Sorokin (Deuteromycotina: Hyphomycetes). Journal of Stored Products Research. 41(2), 221-229. https://doi.org/10.1016/j.jspr.2004.03.007
  • Bayer Crop Science Limited, (2005). Enviromental information sheet folicur® MAPP number 11278. CPA Guidance Notes version3.©EIS.
  • Devasagayam, T.P.A., Boloor, K.K., Ramsarma, T. (2003). Methods for estimating lipid peroxidation: Analysis of merits and demerits (minireview). Indian Journal of Biochemistry and Biophysics, 40(5), 300-308.
  • Das, S.K., Maji, S. Wechman, S.L., Bhoopathi, P., Pradhan A.K., Talukdar S., Sarkar, D., Landry, J., Guo, C. Wang, X.Y., Cavenee W.K., Emdad, L., Fisher, P.B. (2020). MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis, Pharmacological Research, 155, 104695. https://doi.org/10.1016/j.phrs.2020.104695
  • Ellman, G.L., Courtney, K.D., Andres, V. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacology., 7, 88-95. https://doi.org/10.1016/0006-2952(61)90145-9
  • Fetoui, H., Makni, M., Garoui, E.M., Zegha, N. (2010). Toxic effects of lambda-cyhalothrin, a synthetic pyrethroid pesticide, on the rat kidney: Involvement of oxidative stress and protective role of ascorbic acid. Experimental and Toxicologic Pathology, 62(6), 593-599. https://doi.org/10.1016/j.etp.2009.08.004
  • Gao, B., Saralamba, S., Lubell, Y., White, L.J., Dondorp, A.M., Aguas, R. (2020). Determinants of MDA impact and designing MDAs towards malaria elimination. Epidemiology And Global Health, 9, e51773. https://doi.org/10.7554/eLife.51773
  • Glusczak, L., Miron, D.D.S., Moraes, B.S., Simões, R.R., Schetinger, M.R.C., Vânia, V.M., Loro, L., (2007). Acute effects of glyphosate herbicide on metabolic and enzymatic parameters of silver cafish (Rhamdia Quelen). Comparative Biochemistru Biochemistrand Physiology Part C., 146, 519-524. https://doi.org/10.1016/j.cbpc.2007.06.004
  • Lutnicka, H., Bojarskı, B., Ludwıkowska, A., Wroñska, D., Kamıñska, T., Szczygıe £, J., Troszok, A., Szabelan, K., Formıckı, G. (2016). Hematological alterations as a response to exposure to selected fungicides in common carp (Cyprinus carpio L.). Folia Biologica (Kraków), 64(4), 235-244. https://doi.org/10.3409/fb64_4.235
  • Mis, L., Comba, B., Uslu, S. and Yeltekin, A. Ç. (2018). Effect of wheatgrass on DNA damage, oxidative stress index and histological findings in diabetic rats. International Journal of Morphology, 36(4), 1235-1240. https://doi.org/10.4067/S0717-95022018000401235
  • Nasr, I.N., Ahmed, N.S., Al-Maz, M.M. (2003). Effect of boiling and some environmental factors on residues behaviour of penconazole fungicide on vine leaves. Annals of Agricultural Science (Cairo), 48, 365-372.
  • Nong, Q.Y., Liu, Y.A., Qin, L.T., Liu, M. Mo, L.Y., Liang, Y.P., Zeng H.H. (2020). Toxic mechanism of three azole fungicides and their mixture to green alga Chlorella pyrenoidosa, Chemosphere, 262, 127793. https://doi.org/10.1016/j.chemosphere.2020.127793
  • Placer, Z.A., Cushman, L., Johnson, B.C. (1966). Estimation of products of lipid peroxidation (Malonyl dialdehyde) in biological fluids. Analytical Biochemistry, 16(2), 359-364. https://doi.org/10.1016/0003-2697(66)90167-9
  • Parvez, S., Raisuddin, S. (2005). Protein carbonyls: novel biomarkers of exposure to oxidative stress-inducing pesticides in freshwater fish Channa punctata (Bloch), Environmental Toxicology and Pharmacology, 20(1), 112-117. https://doi.org/10.1016/j.etap.2004.11.002
  • Rafael, D.S., Azevedo, Kivia, V.G., Falcão, Caio R.D. Assis, Regildo M.G. Martins, Marlyete, C. Araújo, Gilvan T. Yogui, Jorge L. Neves, Gustavo M. Seabra, Maria B.S. Maia, Ian P.G. Amaral, Ana C.R. Leite, Ranilson Bezerra S. (2021). Effects of pyriproxyfen on zebrafish brain mitochondria and acetylcholinesterase, Chemosphere, 263, 128029. https://doi.org/10.1016/j.chemosphere.2020.128029
  • Ramírez-Santana, M., Zúñiga-Venegas, L., Corral, S., Roeleveld, N., Groenewoud, H., Koosvan der Veldenf Paul, T.J., Floria Pancetti, S. (2020). Association between cholinesterase's inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile. Environmental Research. 186, 109539. https://doi.org/10.1016/j.envres.2020.109539
  • Rossi, G. P., Sanga, V., Barton M. (2020). Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients. Medicine, 9, e57278. https://doi.org/10.7554/eLife.57278
  • Santana, M.S., Sandrini-Neto, L., Di Domenico, M., Prodocimo, M.M. (2021). Pesticide effects on fish cholinesterase variability and mean activity: A meta-analytic review. Science of the Total Environment, 757, 143829. https://doi.org/10.1016/j.scitotenv.2020.143829
  • Sepici-Dincel, A., Benli, A.C., Selvi, M., Sarıkaya, R., Sahin, D., Ozkul, A., Erkoc, F., (2009). Sublethal cyfluthrin toxicity to carp (Cyprinus Carpio L.) Fingerlings: Biochemical, hematological, histopathological alterations. Ecotoxicology and Environmental Safety, 72, 1433-1439. https://doi.org/10.1016/j.ecoenv.2009.01.008
  • Sequeira-Mendes, J., Díaz-Uriarte, R., Apedaile, A., Huntley, D., Brockdorff, N. (2009). Transcription Initiation Activity Sets Replication Origin Efficiency in Mammalian Cells. PLOS Genetics 5(4), e1000446. https://doi.org/10.1371/journal.pgen.1000446
  • Siek, M. M., Paszko, T. (2021). Fate of Tebuconazole in Polish Mineral Soils – Results of Simulations with FOCUS PELMO. Journal of Ecological Engineering, 22(11), 131-141. https://doi.org/10.12911/22998993/142936
  • Souders, C. L., Perez-Rodriguez, V., El Ahmadie, N., Zhang, X., Tischuk, C., Martyniuk, C.J. (2020). Investigation into the sub-lethal effects of the triazole fungicide triticonazole in zebrafish (Danio rerio) embryos/larvae. Environmental Toxicology, 35, 254-267. https://doi.org/10.1002/tox.22862
  • Uçar, A., Özgeriş, F.B., Parlak, V., Yeltekin, A.Ç., Kocaman, E.M., Alak, G., Atamanalp M. (2021). Neurotoxic responses of rainbow trout (Oncorhynchus mykiss) exposed to fipronil: multi-biomarker approach to illuminate the mechanism in brain. Drug and Chemical Toxicology, https://doi.org/10.1080/01480545.2021.1908751 Yeltekin, A.Ç., Oğuz, A.R., İribuğday, F., Ergöz, B. (2018). Investigation of some metal levels in different tissue dependent on the age variation of Van Fish (Alburnus tarichi, Güldenstädt 1814). Süleyman Demirel Üniversitesi Eğirdir Su Ürünleri Fakültesi Dergisi, 14(2), 89-101. https://doi.org/10.22392/egirdir.348088
  • Yeltekin AÇ, Oguz AR, Kankaya E, Ozok N, Guneş, I. (2020). Hematological and biochemical response in the blood of Alburnus Tarichi (Actinopterygii: Cypriniformes: Cyprinidae) exposed to tebuconazole. Acta Ichthyologica Et Piscatoria. 50(4), 373-379. https://doi.org/10.3750/AIEP/02931

Details

Primary Language English
Subjects Marine and Freshwater Biology
Journal Section Research Articles
Authors

Aslı ÇİLİNGİR YELTEKİN (Primary Author)
VAN YUZUNCU YIL UNIVERSITY, FACULTY OF SCIENCE, CHEMISTRY PR.
0000-0003-0071-7434
Türkiye

Early Pub Date January 28, 2022
Publication Date April 1, 2022
Application Date October 11, 2021
Acceptance Date December 15, 2021
Published in Issue Year 2022, Volume 5, Issue 2

Cite

Bibtex @research article { aquatres1008280, journal = {Aquatic Research}, eissn = {2618-6365}, address = {Esnaf Mah. Pembe Köşk Sok. Kentplus Kadıköy Sitesi B Blok D435 Kadıköy-İstanbul}, publisher = {Nuray ERKAN ÖZDEN}, year = {2022}, volume = {5}, number = {2}, pages = {110 - 116}, doi = {10.3153/AR22010}, title = {The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity}, key = {cite}, author = {Çilingir Yeltekin, Aslı} }
APA Çilingir Yeltekin, A. (2022). The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity . Aquatic Research , 5 (2) , 110-116 . DOI: 10.3153/AR22010
MLA Çilingir Yeltekin, A. "The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity" . Aquatic Research 5 (2022 ): 110-116 <https://aquatres.scientificwebjournals.com/en/pub/issue/68273/1008280>
Chicago Çilingir Yeltekin, A. "The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity". Aquatic Research 5 (2022 ): 110-116
RIS TY - JOUR T1 - The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity AU - Aslı Çilingir Yeltekin Y1 - 2022 PY - 2022 N1 - doi: 10.3153/AR22010 DO - 10.3153/AR22010 T2 - Aquatic Research JF - Journal JO - JOR SP - 110 EP - 116 VL - 5 IS - 2 SN - -2618-6365 M3 - doi: 10.3153/AR22010 UR - https://doi.org/10.3153/AR22010 Y2 - 2021 ER -
EndNote %0 Aquatic Research The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity %A Aslı Çilingir Yeltekin %T The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity %D 2022 %J Aquatic Research %P -2618-6365 %V 5 %N 2 %R doi: 10.3153/AR22010 %U 10.3153/AR22010
ISNAD Çilingir Yeltekin, Aslı . "The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity". Aquatic Research 5 / 2 (April 2022): 110-116 . https://doi.org/10.3153/AR22010
AMA Çilingir Yeltekin A. The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity. Aquat Res. 2022; 5(2): 110-116.
Vancouver Çilingir Yeltekin A. The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity. Aquatic Research. 2022; 5(2): 110-116.
IEEE A. Çilingir Yeltekin , "The responses of cholinergic system in the brain tissue of Van Fish (Alburnus tarichi) exposed to antifungal tebuconazole compound toxicity", Aquatic Research, vol. 5, no. 2, pp. 110-116, Apr. 2022, doi:10.3153/AR22010

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