Research Article
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Year 2022, Volume: 4 Issue: 2, 277 - 291, 24.08.2022

Abstract

References

  • Abdpour, S., Jalili-Baleh, L., Nadri, H., Forootanfar, H., Bukhari, S.N.A. et al. (2021). Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against alzheimer’s disease, Bioorganic Chemistry, 110. doi:10.1016/J.BIOORG.2021.104750
  • Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J. et al. (2000). Inflammation and Alzheimer’s Disease, Neurobiology of Aging, 21:383–421.
  • Altmann, P., Cunningham, J., Dhanesha, U., Ballard, M., Thompson, J., Marsh, F. (1999). Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: Retrospective study of the camelford water ıncident, British Medical Journal, 319:807–811.
  • Arslan, B.A., Isik, F.B., Gur, H., Ozen, F., Catal, T. (2017). Apoptotic effect of Nigella sativa on human lymphoma U937 cells, Pharmacognosy Magazine, 13:S628–S632.
  • Atasever-Arslan, B., Y. Ozer, F. Ozen, Y. Diler, and A.D. Yalcin, (2020). Tumor necrosis factor alpha gene Rs1799724 polymorphism in Alzheimer’s Disease, General Physiology and Biophysics, 39:595–599.
  • Aydin, D., Weyer, S.W., Müller, U.C. (2012). Functions of the APP gene family in the nervous system: Insights from mouse models, Experimental Brain Research, 217:423–434.
  • Collin, R.W.J., Van Strien, D., Leunissen, J.A.M., Martens, G.J.M. (2004). Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis, European Journal of Biochemistry, 271:1906–1912.
  • Deveci, Y., Gunal-Sadik, G., Akalın-Urusak, E., Kuşoğlu-Gültekin, S., Yanık A., Atasever-Arslan, B. (2021). Anti-diabetic effects of Berberis cretica extract in INS-1E cells, International Journal of Science Letters, 3(2):121-128.
  • Dinamarca, M.C., Cerpa, W., Garrido, J., Hancke, J.L., Inestrosa, N.C. (2006). Hyperforin prevents β-Amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer’s Amyloid-β-deposits, Molecular Psychiatry, 11:1032–1048.
  • Exley, C. (1999). A molecular mechanism of aluminium-induced Alzheimer’s Disease? Journal of Inorganic Biochemistry, Journal of Inorganic Biochemistry, 76(2): 133–140.
  • Fleszar, M.G., Wiśniewski, J., Zboch, M., Diakowska, D., Gamian, A., Krzystek-Korpacka, M. (2019). Targeted metabolomic analysis of nitric oxide/l-arginine pathway metabolites in dementia: Association with pathology, severity, and structural brain changes, Scientific Reports, 9:1–15.
  • Garg, A.D., Krysko, D.V., Vandenabeele, P., Agostinis, P. (2012). Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like Hsp70 and calreticulin, cancer immunology, Immunotherapy, 61:215–221.
  • Griffith, T., Varela-Nallar, L., Dinamarca, M., Inestrosa, N. (2010). Neurobiological effects of hyperforin and its potential in Alzheimers Disease therapy, Current Medicinal Chemistry, 17:391–406.
  • Guan, P.P., Cao, L.L., Wang, P. (2021). Elevating the levels of calcium ıons exacerbate alzheimer’s disease via ınducing the production and aggregation of β-amyloid protein and phosphorylated tau, International Journal of Molecular Sciences, 22(11):5900. doi:10.3390/ijms22115900
  • Hofrichter, J., Krohn, M., Schumacher, T., Lange, C., Feistel, B. et al. (2013). Reduced Alzheimer’s Disease pathology by St. John’s Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice, Current Alzheimer Research, 10:1057–1069.
  • Huang, W., Cheng, P., Yu, K., Han, Y., Song, M., Li, Y. (2017). Hyperforin attenuates aluminum-ınduced aβ production and tau phosphorylation via regulating Akt/GSK-3β signaling pathway in PC12 cells, Biomedicine and Pharmacotherapy, 96:1–6.
  • Ittner, L.M., Götz, J. (2011). Amyloid-β and tau - a toxic Pas de Deux in Alzheimer’s Disease, Nature Reviews Neuroscience, 12:67–72.
  • Kawahara, M., Kato-Negishi, M. (2011). Link between aluminum and the pathogenesis of Alzheimer’s Disease: The integration of the aluminum and amyloid cascade hypotheses, International Journal of Alzheimer’s Disease, doi:10.4061/2011/276393
  • Kaya, B., Atasever-Arslan, B., Kalkan, Z., Gür, H., Ülküseven, B. (2016). Apoptotic mechanisms of nickel(II) complex with N1-acetylacetone-N4- 4-methoxy-salicylidene-S-allyl-thiosemicarbazone on HL60 leukemia cells, General Physiology and Biophysics, 35:451–458.
  • Kitlinska, J. (2007). Neuropeptide Y (NPY) in neuroblastoma: Effect on growth and vascularization, Peptides, 28:405–412.
  • Langui, D., Probst, A., Anderton, B., Brion, J.P., Ulrich, J. (1990). Aluminium-induced tangles in cultured rat neurones - enhanced effect of aluminium by addition of maltol, Acta Neuropathologica, 80:649–655.
  • Liang, R.F., Li, W.Q., Wang, H., Wang, J.X., Niu, Q. (2013). Impact of sub-chronic aluminium-maltolate exposure on catabolism of amyloid precursor protein in rats, Biomedical and Environmental Sciences, 26:445–452.
  • Livak, K.J., Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative pcr and the 2-ΔΔCT method, Methods, 25:402–408.
  • Menzies, F.M., Fleming, A., Caricasole, A., Bento, C.F., Andrews, S.P. et al. (2017). Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities, Neuron, 93:1015–1034.
  • Mir, M.Y., Kamili, A.N., Hassan, Q.P., Rafi, S., Parray, J.A., Jan, S. (2019). In vitro regeneration and free radical scavenging assay of Hypericum perforatum L., National Academy Science Letters, 42:161–167.
  • Muma, N.A., Singer, S.M. (1996). Aluminum-induced neuropathology: Transient changes in microtubule-associated proteins, Neurotoxicology and Teratology, 18:679–690. Nussbaum, J.M., Seward, M.E., Bloom, G.S. (2013). Alzheimer Disease: A tale of two prions. Prion. Taylor & Francis, pp. 14–19.
  • Oliveira, A.I., Pinho, C., Sarmento, B., Dias, A.C.P. (2016). Neuroprotective activity of Hypericum perforatum and its major components, Frontiers in Plant Science, 7. doi:10.3389/fpls.2016.01004
  • Ozer, Y., Ozen, F., Diler, Y., Yalcin, A.D., Atasever-Arslan, B. (2020). Proteasome modulator 9 (PSMD9) gene Rs14259 polymorphism in Alzheimer’s Disease, Bratislava Medical Journal, 121:331–333. Rebai, O., Djebli, N.E. (2008). Chronic exposure to aluminum chloride in mice: Exploratory behaviors and spatial learning, Advances in Biological Research, 2:26–33.
  • del Rio, M.A., Sanchez-Reus, M.I., Iglesias, I., Pozo, M.A., Garcia-Arencibia, M. et al. (2013). Neuroprotective properties of standardized extracts of Hypericum perforatum on rotenone model of Parkinson’s Disease, CNS & Neurological Disorders - Drug Targets, 12:665–679.
  • Rizvi, S.H.M., Parveen, A., Ahmad, I., Ahmad, I., Verma, A.K. et al. (2016). Aluminum activates PERK-EIF2α signaling and inflammatory proteins in human neuroblastoma SH-SY5Y cells, Biological Trace Element Research, 172:108–119.
  • Rizzo, P., Altschmied, L., Ravindran, B.M., Rutten, T., D’auria, J.C. (2020). The biochemical and genetic basis for the biosynthesis of bioactive compounds in Hypericum perforatum L., one of the largest medicinal crops in Europe, Genes, 11:1–21.
  • Vaz, M., Silvestre, S. (2020). Alzheimer’s Disease: Recent treatment strategies, European Journal of Pharmacology, 887. doi:10.1016/j.ejphar.2020.173554
  • Wang, H., Shao, B., Yu, H., Xu, F., Wang, P. et al. (2019). Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells, Chemico-Biological Interactions, 299:15–26.
  • Zhang, T., Wang, S., Niu, Q. (2019). Effect of aluminum-maltolate on the content of Aβ protein and the expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 cells, Neurotoxicity Research, 35:931–944.
  • Zhou, Y., Yokel, R.A. (2005). The Chemical species of aluminum influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption, Toxicological Sciences, 87:15–26.

Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells

Year 2022, Volume: 4 Issue: 2, 277 - 291, 24.08.2022

Abstract

Alzheimer's disease is multi-component neurodegenerative disorder. Oxidative stress disrupts regular functioning of metabolism in early-onset Alzheimer's disease. It causes Tau phosphorylation, formation of neurofibrillary tangle and neuron reduction. Due to intense binding of phosphorylated amino acids to aluminum, it induces self-assembly and deposition of high degree of phosphorylated cytoskeletal proteins, such as microtubule and neurofilament-associated proteins. In this study, it is aimed to consider the antioxidant potential of Hypericum perforatum extract against neurotoxicity caused by Aluminum-maltolate (Al(mal)3) and its effects on APP gene expression. Four different groups were determined to observe the impact of H. perforatum extract. After the incubation of the cells for 24 hours, only the medium was placed in the first group as control. 500 μM Al(mal)3 was added to the second group of cells. 20 μg mL-1 Hypericum perforatum extract was added to the third group. For the fourth group, 20 μg mL-1 Hypericum perforatum extract and 500 μM Al(mal)3 were added. While Al(mal)3 increased total antioxidant status levels in SH-SY5Y human neuroblastoma cells, H. perforatum extract significantly inhibited Al(mal)3 induced oxidative stress. On the other hand, H. perforatum extract significantly decreased APP gene expression levels depending on Al(mal)3 toxicity in SH-SY5Y cells. According to these results, H. perforatum extract significantly inhibited Al(mal)3 neurotoxicity against SH-SY5Y cells. To determine synergistic and antagonistic effects of H. perforatum extract content is important to examine their specific effects of together with hyperforin, which is a phytochemical produced by some of the members of the plant genus Hypericum, to discover new therapeutic agents against neurodegeneration.

References

  • Abdpour, S., Jalili-Baleh, L., Nadri, H., Forootanfar, H., Bukhari, S.N.A. et al. (2021). Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against alzheimer’s disease, Bioorganic Chemistry, 110. doi:10.1016/J.BIOORG.2021.104750
  • Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J. et al. (2000). Inflammation and Alzheimer’s Disease, Neurobiology of Aging, 21:383–421.
  • Altmann, P., Cunningham, J., Dhanesha, U., Ballard, M., Thompson, J., Marsh, F. (1999). Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: Retrospective study of the camelford water ıncident, British Medical Journal, 319:807–811.
  • Arslan, B.A., Isik, F.B., Gur, H., Ozen, F., Catal, T. (2017). Apoptotic effect of Nigella sativa on human lymphoma U937 cells, Pharmacognosy Magazine, 13:S628–S632.
  • Atasever-Arslan, B., Y. Ozer, F. Ozen, Y. Diler, and A.D. Yalcin, (2020). Tumor necrosis factor alpha gene Rs1799724 polymorphism in Alzheimer’s Disease, General Physiology and Biophysics, 39:595–599.
  • Aydin, D., Weyer, S.W., Müller, U.C. (2012). Functions of the APP gene family in the nervous system: Insights from mouse models, Experimental Brain Research, 217:423–434.
  • Collin, R.W.J., Van Strien, D., Leunissen, J.A.M., Martens, G.J.M. (2004). Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis, European Journal of Biochemistry, 271:1906–1912.
  • Deveci, Y., Gunal-Sadik, G., Akalın-Urusak, E., Kuşoğlu-Gültekin, S., Yanık A., Atasever-Arslan, B. (2021). Anti-diabetic effects of Berberis cretica extract in INS-1E cells, International Journal of Science Letters, 3(2):121-128.
  • Dinamarca, M.C., Cerpa, W., Garrido, J., Hancke, J.L., Inestrosa, N.C. (2006). Hyperforin prevents β-Amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer’s Amyloid-β-deposits, Molecular Psychiatry, 11:1032–1048.
  • Exley, C. (1999). A molecular mechanism of aluminium-induced Alzheimer’s Disease? Journal of Inorganic Biochemistry, Journal of Inorganic Biochemistry, 76(2): 133–140.
  • Fleszar, M.G., Wiśniewski, J., Zboch, M., Diakowska, D., Gamian, A., Krzystek-Korpacka, M. (2019). Targeted metabolomic analysis of nitric oxide/l-arginine pathway metabolites in dementia: Association with pathology, severity, and structural brain changes, Scientific Reports, 9:1–15.
  • Garg, A.D., Krysko, D.V., Vandenabeele, P., Agostinis, P. (2012). Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like Hsp70 and calreticulin, cancer immunology, Immunotherapy, 61:215–221.
  • Griffith, T., Varela-Nallar, L., Dinamarca, M., Inestrosa, N. (2010). Neurobiological effects of hyperforin and its potential in Alzheimers Disease therapy, Current Medicinal Chemistry, 17:391–406.
  • Guan, P.P., Cao, L.L., Wang, P. (2021). Elevating the levels of calcium ıons exacerbate alzheimer’s disease via ınducing the production and aggregation of β-amyloid protein and phosphorylated tau, International Journal of Molecular Sciences, 22(11):5900. doi:10.3390/ijms22115900
  • Hofrichter, J., Krohn, M., Schumacher, T., Lange, C., Feistel, B. et al. (2013). Reduced Alzheimer’s Disease pathology by St. John’s Wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice, Current Alzheimer Research, 10:1057–1069.
  • Huang, W., Cheng, P., Yu, K., Han, Y., Song, M., Li, Y. (2017). Hyperforin attenuates aluminum-ınduced aβ production and tau phosphorylation via regulating Akt/GSK-3β signaling pathway in PC12 cells, Biomedicine and Pharmacotherapy, 96:1–6.
  • Ittner, L.M., Götz, J. (2011). Amyloid-β and tau - a toxic Pas de Deux in Alzheimer’s Disease, Nature Reviews Neuroscience, 12:67–72.
  • Kawahara, M., Kato-Negishi, M. (2011). Link between aluminum and the pathogenesis of Alzheimer’s Disease: The integration of the aluminum and amyloid cascade hypotheses, International Journal of Alzheimer’s Disease, doi:10.4061/2011/276393
  • Kaya, B., Atasever-Arslan, B., Kalkan, Z., Gür, H., Ülküseven, B. (2016). Apoptotic mechanisms of nickel(II) complex with N1-acetylacetone-N4- 4-methoxy-salicylidene-S-allyl-thiosemicarbazone on HL60 leukemia cells, General Physiology and Biophysics, 35:451–458.
  • Kitlinska, J. (2007). Neuropeptide Y (NPY) in neuroblastoma: Effect on growth and vascularization, Peptides, 28:405–412.
  • Langui, D., Probst, A., Anderton, B., Brion, J.P., Ulrich, J. (1990). Aluminium-induced tangles in cultured rat neurones - enhanced effect of aluminium by addition of maltol, Acta Neuropathologica, 80:649–655.
  • Liang, R.F., Li, W.Q., Wang, H., Wang, J.X., Niu, Q. (2013). Impact of sub-chronic aluminium-maltolate exposure on catabolism of amyloid precursor protein in rats, Biomedical and Environmental Sciences, 26:445–452.
  • Livak, K.J., Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative pcr and the 2-ΔΔCT method, Methods, 25:402–408.
  • Menzies, F.M., Fleming, A., Caricasole, A., Bento, C.F., Andrews, S.P. et al. (2017). Autophagy and neurodegeneration: Pathogenic mechanisms and therapeutic opportunities, Neuron, 93:1015–1034.
  • Mir, M.Y., Kamili, A.N., Hassan, Q.P., Rafi, S., Parray, J.A., Jan, S. (2019). In vitro regeneration and free radical scavenging assay of Hypericum perforatum L., National Academy Science Letters, 42:161–167.
  • Muma, N.A., Singer, S.M. (1996). Aluminum-induced neuropathology: Transient changes in microtubule-associated proteins, Neurotoxicology and Teratology, 18:679–690. Nussbaum, J.M., Seward, M.E., Bloom, G.S. (2013). Alzheimer Disease: A tale of two prions. Prion. Taylor & Francis, pp. 14–19.
  • Oliveira, A.I., Pinho, C., Sarmento, B., Dias, A.C.P. (2016). Neuroprotective activity of Hypericum perforatum and its major components, Frontiers in Plant Science, 7. doi:10.3389/fpls.2016.01004
  • Ozer, Y., Ozen, F., Diler, Y., Yalcin, A.D., Atasever-Arslan, B. (2020). Proteasome modulator 9 (PSMD9) gene Rs14259 polymorphism in Alzheimer’s Disease, Bratislava Medical Journal, 121:331–333. Rebai, O., Djebli, N.E. (2008). Chronic exposure to aluminum chloride in mice: Exploratory behaviors and spatial learning, Advances in Biological Research, 2:26–33.
  • del Rio, M.A., Sanchez-Reus, M.I., Iglesias, I., Pozo, M.A., Garcia-Arencibia, M. et al. (2013). Neuroprotective properties of standardized extracts of Hypericum perforatum on rotenone model of Parkinson’s Disease, CNS & Neurological Disorders - Drug Targets, 12:665–679.
  • Rizvi, S.H.M., Parveen, A., Ahmad, I., Ahmad, I., Verma, A.K. et al. (2016). Aluminum activates PERK-EIF2α signaling and inflammatory proteins in human neuroblastoma SH-SY5Y cells, Biological Trace Element Research, 172:108–119.
  • Rizzo, P., Altschmied, L., Ravindran, B.M., Rutten, T., D’auria, J.C. (2020). The biochemical and genetic basis for the biosynthesis of bioactive compounds in Hypericum perforatum L., one of the largest medicinal crops in Europe, Genes, 11:1–21.
  • Vaz, M., Silvestre, S. (2020). Alzheimer’s Disease: Recent treatment strategies, European Journal of Pharmacology, 887. doi:10.1016/j.ejphar.2020.173554
  • Wang, H., Shao, B., Yu, H., Xu, F., Wang, P. et al. (2019). Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells, Chemico-Biological Interactions, 299:15–26.
  • Zhang, T., Wang, S., Niu, Q. (2019). Effect of aluminum-maltolate on the content of Aβ protein and the expression of ApoER2, VLDLRs, and LRP1 in PC12-ApoE4 cells, Neurotoxicity Research, 35:931–944.
  • Zhou, Y., Yokel, R.A. (2005). The Chemical species of aluminum influences its paracellular flux across and uptake into Caco-2 cells, a model of gastrointestinal absorption, Toxicological Sciences, 87:15–26.
There are 35 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Rabia Yaren Akkuş

Barış Bitmez

Seda Kuşoğlu Gültekin

İrem Gülfem Albayrak

Fatih Özen This is me 0000-0001-9235-4524

Yiğit Deveci

Yusuf Sıcak

Emine Akalın

Ademi Fahri Pirhan

Belkis Atasever Arslan

Publication Date August 24, 2022
Published in Issue Year 2022 Volume: 4 Issue: 2

Cite

APA Akkuş, R. Y., Bitmez, B., Kuşoğlu Gültekin, S., Albayrak, İ. G., et al. (2022). Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells. International Journal of Science Letters, 4(2), 277-291.
AMA Akkuş RY, Bitmez B, Kuşoğlu Gültekin S, Albayrak İG, Özen F, Deveci Y, Sıcak Y, Akalın E, Pirhan AF, Atasever Arslan B. Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells. IJSL. August 2022;4(2):277-291.
Chicago Akkuş, Rabia Yaren, Barış Bitmez, Seda Kuşoğlu Gültekin, İrem Gülfem Albayrak, Fatih Özen, Yiğit Deveci, Yusuf Sıcak, Emine Akalın, Ademi Fahri Pirhan, and Belkis Atasever Arslan. “Neuroprotective Effect of Hypericum Perforatum Extract Against Aluminum-Maltolate Induced Toxicity in SH-SY5Y Cells”. International Journal of Science Letters 4, no. 2 (August 2022): 277-91.
EndNote Akkuş RY, Bitmez B, Kuşoğlu Gültekin S, Albayrak İG, Özen F, Deveci Y, Sıcak Y, Akalın E, Pirhan AF, Atasever Arslan B (August 1, 2022) Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells. International Journal of Science Letters 4 2 277–291.
IEEE R. Y. Akkuş, “Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells”, IJSL, vol. 4, no. 2, pp. 277–291, 2022.
ISNAD Akkuş, Rabia Yaren et al. “Neuroprotective Effect of Hypericum Perforatum Extract Against Aluminum-Maltolate Induced Toxicity in SH-SY5Y Cells”. International Journal of Science Letters 4/2 (August 2022), 277-291.
JAMA Akkuş RY, Bitmez B, Kuşoğlu Gültekin S, Albayrak İG, Özen F, Deveci Y, Sıcak Y, Akalın E, Pirhan AF, Atasever Arslan B. Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells. IJSL. 2022;4:277–291.
MLA Akkuş, Rabia Yaren et al. “Neuroprotective Effect of Hypericum Perforatum Extract Against Aluminum-Maltolate Induced Toxicity in SH-SY5Y Cells”. International Journal of Science Letters, vol. 4, no. 2, 2022, pp. 277-91.
Vancouver Akkuş RY, Bitmez B, Kuşoğlu Gültekin S, Albayrak İG, Özen F, Deveci Y, Sıcak Y, Akalın E, Pirhan AF, Atasever Arslan B. Neuroprotective effect of Hypericum perforatum extract against aluminum-maltolate induced toxicity in SH-SY5Y cells. IJSL. 2022;4(2):277-91.