Clinical Research
Year 2022,
Volume: 8 Issue: 3, 68 - 79, 31.12.2022
Abstract
Amaç: Dalak, doğuştan ve edinsel bağışıklık sistemi açısından önemli bir role sahiptir. Dalak, genellikle konturları olmayan ve abdominal radyoterapi vakalarında ihmal edilebilme ihtimali olan bir organdır. Bu nedenle dalak dozimetrisi nadiren çalışılmıştır. Bu çalışmada mide kanserli hastalarda dalak radyasyon dozunu ve dalak hacmi kaybı ile ilişkisini araştırmayı amaçladık.
Yöntemler: Veriler, kanserin evreleri, tedavi planı, dalak şekillendirme ve dozimetri, 3 boyutlu bilgisayarlı tomografi (3D CT) gibi klinik ve demografik faktörlerden oluşmaktadır. Tedavi öncesi ve tedavi sonrası fazdaki dalak hacimleri karşılaştırılmıştır.
Bulgular: Medyan V20 değeri 65.5 (0.0-100.0) idi. Radyoterapi öncesi ve sonrası medyan dalak hacimleri sırasıyla 185.1 (71.4-488.0)cm3 ve 138.2 (59.0-429.0) cm3 olarak ölçüldü. Bu hacim kaybının istatistiksel olarak anlamlı olduğu bulundu (p = 0,001).
Sonuç: Üst karın malignitesi, özellikle mide kanseri olan hastaları, hipospleniye bağlı olabilecek enfeksiyonlardan korumak için RT sırasında dikkatli bir şekilde taranmalıdır. Ayrıca, üst abdominal malignitesi olan hastalarda RT'nin dalak hacmi ve dalak fonksiyonu üzerindeki etkilerini netleştirmek için ileriye dönük ve daha geniş örneklemli çalışmalara ihtiyaç vardır.
Keywords
References
- 1 Kleinberg L and Forastiere AA: Chemoradiation in the management of esophageal cancer. J Clin Oncol 25(26): 4110-4117, 2007.
- 2 Stahl M, Stuschke M, Lehmann N, Meyer HJ, Walz MK, Seeber S, Klump B, Budach W, Teichmann R, Schmitt M, Schmitt G, Franke C and Wilke H: Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 23(10): 2310-2317, 2005.
- 3 Bedenne L, Michel P, Bouché O, Milan C, Mariette C, Conroy T, Pezet D, Roullet B, Seitz JF, Herr JP, Paillot B, Arveux P, Bonnetain F and Binquet C: Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: Ffcd 9102. J Clin Oncol 25(10): 1160-1168, 2007.
- 4 Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM and Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 345(10): 725-730, 2001.
- 5 Willett CG and Czito BG: Chemoradiotherapy in gastrointestinal malignancies. Clin Oncol (R Coll Radiol) 21(7): 543-556, 2009.
- 6 Hazard L, Yang G, McAleer MF, Hayman J and Willett C: Principles and techniques of radiation therapy for esophageal and gastroesophageal junction cancers. J Natl Compr Canc Netw 6(9): 870-878, 2008.
- 7 Wals A, Contreras J, Macías J, Fortes I, Rivas D, González P and Herruzo I: Damage assessment in gastric cancer treatment with adjuvant radiochemotherapy: Calculation of the ntcp's from the differential hdv of the organs at risk. Clin Transl Oncol 8(4): 271-278, 2006.
- 8 Leong T, Willis D, Joon DL, Condron S, Hui A and Ngan SY: 3d conformal radiotherapy for gastric cancer--results of a comparative planning study. Radiother Oncol 74(3): 301-306, 2005.
- 9 Hong TS, Craft DL, Carlsson F and Bortfeld TR: Multicriteria optimization in intensity-modulated radiation therapy treatment planning for locally advanced cancer of the pancreatic head. Int J Radiat Oncol Biol Phys 72(4): 1208-1214, 2008.
- 10 Mebius RE and Kraal G: Structure and function of the spleen. Nat Rev Immunol 5(8): 606-616, 2005.
- 11 Pimpl W, Dapunt O, Kaindl H and Thalhamer J: Incidence of septic and thromboembolic-related deaths after splenectomy in adults. Br J Surg 76(5): 517-521, 1989.
- 12 Hansen K and Singer DB: Asplenic-hyposplenic overwhelming sepsis: Postsplenectomy sepsis revisited. Pediatr Dev Pathol 4(2): 105-121, 2001.
- 13 Viste A, Haùgstvedt T, Eide GE and Søreide O: Postoperative complications and mortality after surgery for gastric cancer. Ann Surg 207(1): 7-13, 1988.
- 14 Ichikawa D, Kurioka H, Yamaguchi T, Koike H, Okamoto K, Otsuji E, Shirono K, Shioaki Y, Ikeda E, Mutoh F and Yamagishi H: Postoperative complications following gastrectomy for gastric cancer during the last decade. Hepatogastroenterology 51(56): 613-617, 2004.
- 15 Kyriazanos ID, Tachibana M, Yoshimura H, Kinugasa S, Dhar DK and Nagasue N: Impact of splenectomy on the early outcome after oesophagectomy for squamous cell carcinoma of the oesophagus. Eur J Surg Oncol 28(2): 113-119, 2002.
- 16 Jockovich M, Mendenhall NP, Sombeck MD, Talbert JL, Copeland EM, 3rd and Bland KI: Long-term complications of laparotomy in hodgkin's disease. Ann Surg 219(6): 615-621; discussion 621-614, 1994.
- 17 Moertel CG, Childs DS, Jr., Reitemeier RJ, Colby MY, Jr. and Holbrook MA: Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2(7626): 865-867, 1969.
- 18 Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L and Emami B: Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326(24): 1593-1598, 1992.
- 19 Dailey MO, Coleman CN and Kaplan HS: Radiation-induced splenic atrophy in patients with hodgkin's disease and non-hodgkin's lymphomas. N Engl J Med 302(4): 215-217, 1980.
- 20 Weinmann M, Becker G, Einsele H and Bamberg M: Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases. Strahlenther Onkol 177(2): 105-111, 2001.
- 21 Spencer RP and Pearson HA: Splenic radiocolloid uptake in the presence of circulation howell-jolly bodies. J Nucl Med 15(4): 294-295, 1974.
- 22 Knecht H, Jost R, Gmür J, Burger J and Fehr J: Functional hyposplenia after allogeneic bone marrow transplantation is detected by epinephrine stimulation test and splenic ultrasonography. Eur J Haematol 41(4): 382-387, 1988.
- 23 Weiner MA, Landmann RG, DeParedes L and Leventhal BG: Vesiculated erythrocytes as a determination of splenic reticuloendothelial function in pediatric patients with hodgkin's disease. J Pediatr Hematol Oncol 17(4): 338-341, 1995.
- 24 Coleman CN, McDougall IR, Dailey MO, Ager P, Bush S and Kaplan HS: Functional hyposplenia after splenic irradiation for hodgkin's disease. Ann Intern Med 96(1): 44-47, 1982.
- 25 Trip AK, Sikorska K, van Sandick JW, Heeg M, Cats A, Boot H, Jansen EP and Verheij M: Radiation-induced dose-dependent changes of the spleen following postoperative chemoradiotherapy for gastric cancer. Radiother Oncol 116(2): 239-244, 2015.
Year 2022,
Volume: 8 Issue: 3, 68 - 79, 31.12.2022
Abstract
References
- 1 Kleinberg L and Forastiere AA: Chemoradiation in the management of esophageal cancer. J Clin Oncol 25(26): 4110-4117, 2007.
- 2 Stahl M, Stuschke M, Lehmann N, Meyer HJ, Walz MK, Seeber S, Klump B, Budach W, Teichmann R, Schmitt M, Schmitt G, Franke C and Wilke H: Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol 23(10): 2310-2317, 2005.
- 3 Bedenne L, Michel P, Bouché O, Milan C, Mariette C, Conroy T, Pezet D, Roullet B, Seitz JF, Herr JP, Paillot B, Arveux P, Bonnetain F and Binquet C: Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: Ffcd 9102. J Clin Oncol 25(10): 1160-1168, 2007.
- 4 Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM and Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 345(10): 725-730, 2001.
- 5 Willett CG and Czito BG: Chemoradiotherapy in gastrointestinal malignancies. Clin Oncol (R Coll Radiol) 21(7): 543-556, 2009.
- 6 Hazard L, Yang G, McAleer MF, Hayman J and Willett C: Principles and techniques of radiation therapy for esophageal and gastroesophageal junction cancers. J Natl Compr Canc Netw 6(9): 870-878, 2008.
- 7 Wals A, Contreras J, Macías J, Fortes I, Rivas D, González P and Herruzo I: Damage assessment in gastric cancer treatment with adjuvant radiochemotherapy: Calculation of the ntcp's from the differential hdv of the organs at risk. Clin Transl Oncol 8(4): 271-278, 2006.
- 8 Leong T, Willis D, Joon DL, Condron S, Hui A and Ngan SY: 3d conformal radiotherapy for gastric cancer--results of a comparative planning study. Radiother Oncol 74(3): 301-306, 2005.
- 9 Hong TS, Craft DL, Carlsson F and Bortfeld TR: Multicriteria optimization in intensity-modulated radiation therapy treatment planning for locally advanced cancer of the pancreatic head. Int J Radiat Oncol Biol Phys 72(4): 1208-1214, 2008.
- 10 Mebius RE and Kraal G: Structure and function of the spleen. Nat Rev Immunol 5(8): 606-616, 2005.
- 11 Pimpl W, Dapunt O, Kaindl H and Thalhamer J: Incidence of septic and thromboembolic-related deaths after splenectomy in adults. Br J Surg 76(5): 517-521, 1989.
- 12 Hansen K and Singer DB: Asplenic-hyposplenic overwhelming sepsis: Postsplenectomy sepsis revisited. Pediatr Dev Pathol 4(2): 105-121, 2001.
- 13 Viste A, Haùgstvedt T, Eide GE and Søreide O: Postoperative complications and mortality after surgery for gastric cancer. Ann Surg 207(1): 7-13, 1988.
- 14 Ichikawa D, Kurioka H, Yamaguchi T, Koike H, Okamoto K, Otsuji E, Shirono K, Shioaki Y, Ikeda E, Mutoh F and Yamagishi H: Postoperative complications following gastrectomy for gastric cancer during the last decade. Hepatogastroenterology 51(56): 613-617, 2004.
- 15 Kyriazanos ID, Tachibana M, Yoshimura H, Kinugasa S, Dhar DK and Nagasue N: Impact of splenectomy on the early outcome after oesophagectomy for squamous cell carcinoma of the oesophagus. Eur J Surg Oncol 28(2): 113-119, 2002.
- 16 Jockovich M, Mendenhall NP, Sombeck MD, Talbert JL, Copeland EM, 3rd and Bland KI: Long-term complications of laparotomy in hodgkin's disease. Ann Surg 219(6): 615-621; discussion 621-614, 1994.
- 17 Moertel CG, Childs DS, Jr., Reitemeier RJ, Colby MY, Jr. and Holbrook MA: Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2(7626): 865-867, 1969.
- 18 Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L and Emami B: Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326(24): 1593-1598, 1992.
- 19 Dailey MO, Coleman CN and Kaplan HS: Radiation-induced splenic atrophy in patients with hodgkin's disease and non-hodgkin's lymphomas. N Engl J Med 302(4): 215-217, 1980.
- 20 Weinmann M, Becker G, Einsele H and Bamberg M: Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases. Strahlenther Onkol 177(2): 105-111, 2001.
- 21 Spencer RP and Pearson HA: Splenic radiocolloid uptake in the presence of circulation howell-jolly bodies. J Nucl Med 15(4): 294-295, 1974.
- 22 Knecht H, Jost R, Gmür J, Burger J and Fehr J: Functional hyposplenia after allogeneic bone marrow transplantation is detected by epinephrine stimulation test and splenic ultrasonography. Eur J Haematol 41(4): 382-387, 1988.
- 23 Weiner MA, Landmann RG, DeParedes L and Leventhal BG: Vesiculated erythrocytes as a determination of splenic reticuloendothelial function in pediatric patients with hodgkin's disease. J Pediatr Hematol Oncol 17(4): 338-341, 1995.
- 24 Coleman CN, McDougall IR, Dailey MO, Ager P, Bush S and Kaplan HS: Functional hyposplenia after splenic irradiation for hodgkin's disease. Ann Intern Med 96(1): 44-47, 1982.
- 25 Trip AK, Sikorska K, van Sandick JW, Heeg M, Cats A, Boot H, Jansen EP and Verheij M: Radiation-induced dose-dependent changes of the spleen following postoperative chemoradiotherapy for gastric cancer. Radiother Oncol 116(2): 239-244, 2015.
There are 25 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 31, 2022 |
| Published in Issue | Year 2022 Volume: 8 Issue: 3 |
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