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MILK, INSULIN LIKE GROWTH FACTOR (IGF-1) and HEALTH

Year 2022, Volume: 47 Issue: 6, 1140 - 1152, 15.12.2022
https://doi.org/10.15237/gida.GD22084

Abstract

Insulin-like growth factor (IGF-1), present in varying amounts in all mammalian milks, is a major regulator of the growth gene signaling system in the newborn. The main biological functions of IGF-1, an important anabolic hormone, are the regulation of cell metabolism, growth, cell proliferation, and programmed cell death (apoptosis). There are studies that reveal positive and negative effects or disease risks on human health with the level of IGF-1 in serum. A low level of serum IGF-1 is associated with the risk of cardiovascular diseases, cardiac autophagy, hypertension, sarcopenia, nervous system diseases, and type 2 diabetes, while a high IGF-1 level is associated with prostate, premenopausal breast, and colorectal cancers and short life expectancy. IGF-1 is known to have a protective effect against Alzheimer's, dementia, and Parkinson's disease. When systematic reviews and meta-analysis studies are examined, it is clear that more studies are needed to obtain more consistent results regarding IGF-1 levels and the health effects of milk consumption. In addition, there are insufficient studies on how IGF-1 in milk is affected by milk processing and digestion, in terms of quantity and molecular level.

References

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SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK

Year 2022, Volume: 47 Issue: 6, 1140 - 1152, 15.12.2022
https://doi.org/10.15237/gida.GD22084

Abstract

Tüm memeli sütlerinde farklı miktarlarda bulunan insülin benzeri büyüme faktörü (IGF-1) yenidoğan için büyüme gen sinyalizasyon sisteminin başlıca düzenleyicisidir. Önemli bir anabolik hormon olan IGF-1’in temel biyolojik fonksiyonları hücre metabolizmasının düzenlenmesi, büyüme, hücre çoğalması ve programlı hücre ölümüdür. Serumdaki IGF-1’in seviyesi ile insan sağlığı üzerine olumlu ve olumsuz etkilerini veya hastalık risklerini ortaya koyan çalışmalar bulunmaktadır. Serum IGF-1 seviyesindeki azalma, kalp-damar hastalıkları, kalp otofaji, hipertansiyon, sarkopeni, sinir sistemi hastalıkları ve tip 2 diyabet riskleri ile ilişkilendirilirken, yüksek IGF-1 miktarı prostat, menopoz öncesi meme ve kolerektal kanserlerle ve yaşam süresinin kısalmasıyla bağlantılı bulunmaktadır. IGF-1’in Alzheimer, demans, Parkinson hastalıklarından koruyucu etkisi olduğu bilinmektedir. Sistematik derlemeler ve meta analiz çalışmaları incelendiğinde, süt tüketiminin IGF-1 seviyesi ve sağlık üzerine etkileri ile ilgili daha tutarlı sonuçlar elde etmek için daha fazla çalışmaya ihtiyaç olduğu anlaşılmaktadır. Ayrıca sütteki IGF-1’in miktar olarak ve moleküler düzeyde, süte uygulanan ısısal olan veya olmayan işlemlerden ve sindirimden nasıl etkilendiğine dair çalışmalar yetersizdir.

References

  • Assunção, R., Pires, S. M., & Nauta, M. (2019). Risk-Benefit Assessment of Foods. EFSA Journal, 17(S2). https://doi.org/10.2903/J.EFSA.2019.E170917
  • Blum, J. W., & Baumrucker, C. R. (2008). Insulin-like growth factors (IGFs), IGF binding proteins, and other endocrine factors in milk: Role in the Newborn. Advances in Experimental Medicine and Biology, 606, 397–422. https://doi.org/10.1007/978-0-387-74087-4_16
  • Clatici, V. G., Voicu, C., Voaides, C., Roseanu, A., Icriverzi, M., & Jurcoane, S. (2018). Diseases of Civilization – Cancer, Diabetes, Obesity and Acne – the Implication of Milk, IGF-1 and mTORC1. Mædica, 13(4), 273. https://doi.org/10.26574/MAEDICA.2018.13.4.273
  • Crowe, F. L., Key, T. J., Allen, N. E., Appleby, P. N., Roddam, A., ... Kaaks, R. (2009). The association between diet and serum concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, Biomarkers & Prevention, 18(5), 1333-40. https://doi.org/10.1158/1055-9965.EPI-08-0781
  • Elfstrand, L., Lindmark-Månsson, H., Paulsson, M., Nyberg, L., & Åkesson, B. (2002). Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing. International Dairy Journal, 12(11), 879–887. https://doi.org/10.1016/S0958-6946(02)00089-4
  • Givens, D. I. (2020). MILK Symposium review: The importance of milk and dairy foods in the diets of infants, adolescents, pregnant women, adults, and the elderly. In Journal of Dairy Science (Vol. 103, Issue 11, pp. 9681–9699). Elsevier Inc. https://doi.org/10.3168/jds.2020-18296
  • Grenov, B., Larnkjær, A., Ritz, C., Michaelsen, K. F., Damsgaard, C. T., & Mølgaard, C. (2021). The effect of milk and rapeseed protein on growth factors in 7–8 year-old healthy children – A randomized controlled trial. Growth Hormone and IGF Research, 60–61. https://doi.org/10.1016/j.ghir.2021.101418
  • Guijarro, L. G., Cano-Martínez, D., Toledo-Lobo, M. V., Salinas, P. S., ...(2021). Relationship between IGF-1 and body weight in inflammatory bowel diseases: Cellular and molecular mechanisms involved. Biomedicine and Pharmacotherapy, 144. https://doi.org/10.1016/j.biopha.2021.112239
  • Guo, J. Y., Zhang, Y. Q., Li, Y., & Li, H. (2021). Comparison of the difference in serum insulin growth factor-1 levels between chronological age and bone age among children. Clinical Biochemistry, 96(March), 63–70. https://doi.org/10.1016/j.clinbiochem.2021.07.008
  • Harrison, S., Lennon, R., Holly, J., Higgins, J. P. T., Gardner, M., Perks, C., Gaunt, T., Tan, V., Borwick, C., Emmet, P., ..(2017). Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis. Cancer Causes and Control, 28(6), 497–528. https://doi.org/10.1007/S10552-017-0883-1
  • Hoeflich, A., & Meyer, Z. (2017). Functional analysis of the IGF-system in milk. In Best Practice and Research: Clinical Endocrinology and Metabolism (Vol. 31, Issue 4, pp. 409–418). Bailliere Tindall Ltd. https://doi.org/10.1016/j.beem.2017.10.002
  • Hoppe, C., Mølgaard, C., Vaag, A. vd., (2005). High intakes of milk, but not meat, increase insulin and insulin resistance in 8-year-old boys, Eur. J. Clin. Nutr. 59, 393–398, https:/doi.org/10.1038/sj.ejcn.1602086
  • Kang, S. H., Kim, J. U., Imm, J. Y., Oh, S., & Kim, S. H. (2006). The effects of dairy processes and storage on insulin-like growth factor-I (IGF-I) content in milk and in model IGF-I-fortified dairy products. Journal of Dairy Science, 89(2), 402–409. https://doi.org/10.3168/jds.S0022-0302(06)72104-X
  • Kilic-Akyilmaz, M., Ozer, B., Bulat, T., & Topcu, A. (2022). Effect of heat treatment on micronutrients, fatty acids and some bioactive components of milk. In International Dairy Journal (Vol. 126). Elsevier Ltd. https://doi.org/10.1016/j.idairyj.2021.105231
  • Kim, S. Y., & Yi, D. Y. (2020). Components of human breast milk: from macronutrient to microbiome and microRNA. Clinical and Experimental Pediatrics, 63(8), 301. https://doi.org/10.3345/CEP.2020.00059
  • Kirovski, D, Knezevic, D. Golic, B. vd., (2021). Cow milk insulin like growth factor-1: risk or benefit for human health? Proceedings of the XII International Scientific Agricultural Symposium. Agrosym, 1196-1203. https://veterinar.vet.bg.ac.rs/handle/123456789/2274
  • Kord-Varkaneh, H., Rinaldi, G., Hekmatdoost, A., Fatahi, S., Tan, S. C., Shadnoush, M., Khani, V., Mousavi, S. M., Zarezadeh, M., Salamat, S., Bawadi, H., & Rahmani, J. (2020). The influence of vitamin D supplementation on IGF-1 levels in humans: A systematic review and meta-analysis. Ageing Research Reviews, 57(July 2019), 100996. https://doi.org/10.1016/j.arr.2019.100996
  • Larnkjaer, A., Hoppe, C., Mølgaard, C., & Michaelsen, K. F. (2009). The effects of whole milk and infant formula on growth and IGF-I in late infancy. European Journal of Clinical Nutrition, 63, 956–963. https://doi.org/10.1038/ejcn.2008.80
  • Lee, D. H., Tabung, F. K., & Giovannucci, E. L. (2022). Association of animal and plant protein intakes with biomarkers of insulin and insulin-like growth factor axis. Clinical Nutrition, 41(6), 1272–1280. https://doi.org/10.1016/j.clnu.2022.04.003
  • Lewitt, M.S., Boyd, W.G. (2019) The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor–Binding Proteins in the Nervous System. Biochemistry Insight,12, 1-18. DOI: 10.1177/1178626419842176.
  • Mann, S., Curone, G., Chandler, T. L., Moroni, P., Cha, J., Bhawal, R., & Zhang, S. (2020). Heat treatment of bovine colostrum: I. Effects on bacterial and somatic cell counts, immunoglobulin, insulin, and IGF-I concentrations, as well as the colostrum proteome. Journal of Dairy Science, 103(10), 9368–9383. https://doi.org/10.3168/jds.2020-18618
  • Ollikainen, P., & Muuronen, K. (2013). Determination of insulin-like growth factor-1 and bovine insulin in raw milk and its casein and whey fractions after microfiltration and ultrafiltration. International Dairy Journal, 28(2), 83–87. https://doi.org/10.1016/j.idairyj.2012.09.001
  • Ollikainen, P., & Riihimäki, A. M. (2012). Effects of heat-treatment on insulin-like growth factor-1 in bovine milk. International Dairy Journal, 23(2), 73–78. https://doi.org/10.1016/j.idairyj.2011.11.002
  • Ong, K., Kratzsch, J., Kiess, W., & Dunger, D. (2002). Circulating IGF-I Levels in Childhood Are Related to Both Current Body Composition and Early Postnatal Growth Rate. https://academic.oup.com/jcem/article/87/3/1041/2846704
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Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Articles
Authors

Sedef Nehir El 0000-0002-2996-0537

Sibel Karakaya 0000-0001-5514-9521

Early Pub Date October 19, 2022
Publication Date December 15, 2022
Published in Issue Year 2022 Volume: 47 Issue: 6

Cite

APA El, S. N., & Karakaya, S. (2022). SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK. Gıda, 47(6), 1140-1152. https://doi.org/10.15237/gida.GD22084
AMA El SN, Karakaya S. SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK. The Journal of Food. December 2022;47(6):1140-1152. doi:10.15237/gida.GD22084
Chicago El, Sedef Nehir, and Sibel Karakaya. “SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) Ve SAĞLIK”. Gıda 47, no. 6 (December 2022): 1140-52. https://doi.org/10.15237/gida.GD22084.
EndNote El SN, Karakaya S (December 1, 2022) SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK. Gıda 47 6 1140–1152.
IEEE S. N. El and S. Karakaya, “SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK”, The Journal of Food, vol. 47, no. 6, pp. 1140–1152, 2022, doi: 10.15237/gida.GD22084.
ISNAD El, Sedef Nehir - Karakaya, Sibel. “SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) Ve SAĞLIK”. Gıda 47/6 (December 2022), 1140-1152. https://doi.org/10.15237/gida.GD22084.
JAMA El SN, Karakaya S. SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK. The Journal of Food. 2022;47:1140–1152.
MLA El, Sedef Nehir and Sibel Karakaya. “SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) Ve SAĞLIK”. Gıda, vol. 47, no. 6, 2022, pp. 1140-52, doi:10.15237/gida.GD22084.
Vancouver El SN, Karakaya S. SÜT, İNSÜLİN BENZERİ BÜYÜME FAKTÖRÜ (IGF-1) ve SAĞLIK. The Journal of Food. 2022;47(6):1140-52.

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