Clinical Research
Year 2023,
Volume: 5 Issue: 2, 25 - 27, 31.08.2023
Abstract
References
- Nelson LS, Hoffman RS, Howland MA, Lewin NA, Goldfrank LR. Goldfrank's toxicologic emergencies: McGraw Hill Professional; 2018.
- Chandrasekaran V, Parthasarathy A, Muruga B. Theophylline toxicity: successful management of a patient with distributive shock secondary to drug overdose. Am J Emerg Med. 2020;38(11):2491. e1-. e2.
- Tintinalli JE, Stapczynski JS, Ma O, Yealy D, Meckler G, Cline D. Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 8e: McGraw Hill Education; 2016.
- Fisher J, Graudins A. Intermittent haemodialysis and sustained low-efficiency dialysis (SLED) for acute theophylline toxicity. J Med Toxicol. 2015;11:359-63.
- Shannon MW, Borron SW, Burns MJ, Haddad LM, Winchester JF. Haddad and Winchester's clinical management of poisoning and drug overdose: Saunders/Elsevier; 2007.
- Berteram G Katzung K, editor Basic & clinical pharmacology2021: EGC.
- Parr M, Anaes F, Day A, Kletchko S, Crone P, Rankin A. Theophylline poisoning—a review of 64 cases. Intensive Care Med. 1990;16:394-8.
- Hafez R. Serum theophylline level as predictor for complications in adults with acute theophylline overdose. Ain Shams Journal of Forensic Medicine and Clinical Toxicology. 2018;30(1):18-26.
- Bronstein AC, Spyker DA, Cantilena JR M, Louis R, Green JL, Rumack BH, G et al. 2009 Annual report of the American Association of Poison Control Centers' national poison data system (NPDS): 27th annual report. J Clin Toxicol. 2010;48(10):979-1178.
- McCoubrie D, Murray L, Daly F, Little M. Toxicology case of the month: ingestion of two unidentified tablets by a toddler. Emerg Med J. 2006;23(9):718-20.
- Hocaoğlu N, Aydin B, Tuncok Y, Kalkan Ş, Yildiztepe E, Bayram B. Demographic and clinical characteristics of theophylline exposures between 1993 and 2011. Balkan Med J. 2014;31(4):322-7.
- Sessler CN. Theophylline toxicity: clinical features of 116 consecutive cases. Am J Med. 1990;88(6):567-76.
- Shannon M. Life-threatening events after theophylline overdose: a 10-year prospective analysis. Arch Intern Med. 1999;159(9):989-94.
- Shannon M, Lovejoy Jr FH. Effect of acute versus chronic intoxication on clinical features of theophylline poisoning in children. J Pediatr. 1992;121(1):125-30.
- Afshari R, Majdzadeh R, Balai‐Mood M. Pattern of acute poisonings in Mashhad, Iran 1993–2000. J Toxicol Clin Toxicol. 2004;42(7):965-75.
Year 2023,
Volume: 5 Issue: 2, 25 - 27, 31.08.2023
Abstract
Background: Theophylline belongs to the category of bronchodilators and belongs to the family of methylxanthines. The purpose of this study was the epidemiological and clinical investigation of theophylline poisoning in patients admitted to Loghman Hakim Hospital in Tehran.
Methods: This retrospective study reviewed the archived files of hospitalized patients from 2012 to 2022 by developing a questionnaire. All demographic information and results of examinations and laboratory tests were extracted from the files. The collected data were analyzed by SPSS version 25 software.
Results: The age range of the patients was 3 months to 57 years. Out of 34 studied patients, 79.4% were female and 20.6% were male. The most common symptoms of poisoning were vomiting, nausea, sinus tachycardia, hyperglycemia and respiratory alkalosis. The incidence of hyperglycemia was 47.1%. One person had died.
Conclusion: Poisoning with theophylline is uncommon and is mainly caused by self-harm. Except in severe poisonings, death and serious complications have not followed, and they have mostly recovered with supportive and symptomatic treatments.
Keywords
References
- Nelson LS, Hoffman RS, Howland MA, Lewin NA, Goldfrank LR. Goldfrank's toxicologic emergencies: McGraw Hill Professional; 2018.
- Chandrasekaran V, Parthasarathy A, Muruga B. Theophylline toxicity: successful management of a patient with distributive shock secondary to drug overdose. Am J Emerg Med. 2020;38(11):2491. e1-. e2.
- Tintinalli JE, Stapczynski JS, Ma O, Yealy D, Meckler G, Cline D. Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 8e: McGraw Hill Education; 2016.
- Fisher J, Graudins A. Intermittent haemodialysis and sustained low-efficiency dialysis (SLED) for acute theophylline toxicity. J Med Toxicol. 2015;11:359-63.
- Shannon MW, Borron SW, Burns MJ, Haddad LM, Winchester JF. Haddad and Winchester's clinical management of poisoning and drug overdose: Saunders/Elsevier; 2007.
- Berteram G Katzung K, editor Basic & clinical pharmacology2021: EGC.
- Parr M, Anaes F, Day A, Kletchko S, Crone P, Rankin A. Theophylline poisoning—a review of 64 cases. Intensive Care Med. 1990;16:394-8.
- Hafez R. Serum theophylline level as predictor for complications in adults with acute theophylline overdose. Ain Shams Journal of Forensic Medicine and Clinical Toxicology. 2018;30(1):18-26.
- Bronstein AC, Spyker DA, Cantilena JR M, Louis R, Green JL, Rumack BH, G et al. 2009 Annual report of the American Association of Poison Control Centers' national poison data system (NPDS): 27th annual report. J Clin Toxicol. 2010;48(10):979-1178.
- McCoubrie D, Murray L, Daly F, Little M. Toxicology case of the month: ingestion of two unidentified tablets by a toddler. Emerg Med J. 2006;23(9):718-20.
- Hocaoğlu N, Aydin B, Tuncok Y, Kalkan Ş, Yildiztepe E, Bayram B. Demographic and clinical characteristics of theophylline exposures between 1993 and 2011. Balkan Med J. 2014;31(4):322-7.
- Sessler CN. Theophylline toxicity: clinical features of 116 consecutive cases. Am J Med. 1990;88(6):567-76.
- Shannon M. Life-threatening events after theophylline overdose: a 10-year prospective analysis. Arch Intern Med. 1999;159(9):989-94.
- Shannon M, Lovejoy Jr FH. Effect of acute versus chronic intoxication on clinical features of theophylline poisoning in children. J Pediatr. 1992;121(1):125-30.
- Afshari R, Majdzadeh R, Balai‐Mood M. Pattern of acute poisonings in Mashhad, Iran 1993–2000. J Toxicol Clin Toxicol. 2004;42(7):965-75.
There are 15 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Emergency Medicine |
| Journal Section | Original Articles |
| Authors | |
| Publication Date | August 31, 2023 |
| Submission Date | May 21, 2023 |
| Published in Issue | Year 2023 Volume: 5 Issue: 2 |
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