Research Article
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Vitamin D ve magnezyum arasındaki ilişki

Year 2023, Volume: 48 Issue: 2, 402 - 408, 02.07.2023
https://doi.org/10.17826/cumj.1184194

Abstract

Amaç: Sağlıklı kemik yapısında önemli rol oynayan D Vitamini steroid yapıda bir hormondur. Magnezyum ise birçok görevinin yanısıra D vitamin sentezi ve yıkımı enzimlerin de kofaktörü olarak rol almaktadır. D vitamin eksikliği veya yetersizliğinde aynı zamanda Magnezyum düşüklüğünün de olup olmadığını anlamak bu çalışmanın amacıdır.
Gereç veYöntem: Herhangi bir sebeple 3. basamak hastanemiz dahiliye polikliniğine 01.10.2018-01.10.2020 tarihleri arasında başvuran 18 yaş üzerindeki hastalar taranıp gluko, ALT, kreatinin, D vitamini, magnezyum değerlerinin hepsi aynı anda test edilmiş hastalar seçildi. Gebeler ve emzirenler, malignitesi olanlar, kronik böbrek yetmezliği olanlar, hiperparatiroidisi, hipoparatiroidisiolanlar, D vitamin veya magnezyum desteği alanlar elendi. Geriye kalan hastaların yaş, cinsiyet ve laboratuvar değerleri kaydedildi.
Bulgular: Bu çalışmaya 1197’si erkekve 4785’i kadın 5982 hasta alınmıştır. Olguların yaşları ortalaması 42’dir. D vitamin değerleri ile magnezyum ve glukoz değerleri arasında istatistiksel olarak anlamlı bir ilişki bulunmamaktadır. Ancak D vitamin ile yaş, kreatininve ALT arasında istatistiksel olarak anlamlı bir ilişki mevcuttur ayrıca kadınlarda hem D vitamini hem de magnezyum düzeyi erkeklere göre istatistiksel olarak anlamlı düzeyde daha düşük bulunmuştur.
Sonuç: D Vitamini ile magnezyum arasında bir ilişki saptanamadığından dolayı D vitamin tedavisi başlanacak olan D vitamin eksik veya yetersiz hastalara rutin magnezyum tetkikinin de yapılmasına gerek yoktur.

References

  • Dobson R, Cock HR, Brex P, Giovannoni G. Vitamin D supplementation. PractNeurol. 2018;18:35-42.
  • Erem S, Atfi A, Razzaque MS. An abolic effects of vitamin D and magnesium in aging bone. J Steroid BiochemMol Biol. 2019;193:105400.
  • Goltzman D. Functions of vitamin D in bone. Histochem Cell Biol. 2018;149:305-12.
  • Öksüz A, Kutlu R. Meram Tıp Fakültesi Hastanesi Aile Hekimliği Polikliniğine başvuran hastaların D vitamin düzeylerinin değerlendirilmesi. Konuralp Tıp Dergisi. 2018;10:160-4.
  • Holic MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention Rev EndocrMetabDisord. 2017;18:153-65.
  • Zmijewski MA. Vitamin D and human health. Int J MolSci. 2019;20:145.
  • Capozzi A, Scambia G, Lello S. Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletalhealth. Maturitas. 2020;140:55-63.
  • Uwitonze A.M, Razzaque M.S. Role of magnesium in vitamin D activation and function. J Am Osteopath Assoc. 2018;118:181-9.
  • AllgroveJ. Physiology of calcium, phosphate, magnesium and vitamin D. Endocr Dev. 2015;28:7-32.
  • Razzaque MS. Magnesium: are we consuming enough? Nutrients. 2018;10:1863.
  • Rosanoff A, Dai Q, Shapses SA. Essential nutrient interactions: does low or suboptimal magnesium status interact with vitamin D and/or calcium status? AdvNutr. 2016;7:25–43.
  • LeFevre ML, LeFevre NM. Vitamin D screening and supplementation in community-dwelling adults: common questions and answers. Am Fam Physician. 2018;15:254-60.
  • Forrest H. Nielsen, LuAnn K. Johnson, Huawei Zeng. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res. 2010;23:158-68.
  • Reddy P,Edwards L. Magnesium supplementation in Vitamin D deficiency. Am J Ther. 2019;26:e124-32.
  • DaiQ, ZhuX, Manson J, Song Y, Li X , Franke A et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J ClinNutr.2018;108:1249-58.

Relationship between vitamin D and magnesium

Year 2023, Volume: 48 Issue: 2, 402 - 408, 02.07.2023
https://doi.org/10.17826/cumj.1184194

Abstract

Purpose: Vitamin D is a steroid hormone that plays an essential role in healthy bone structure. Magnesium plays a role as a cofactor for enzymes in vitamin D synthesis and degradation. The study aims to determine whether there is also accompanying magnesium deficiency, in patients with vitamin D deficiency or insufficiency.
Materials and Methods: Patients over the age of 18 who applied to the internal medicine outpatient clinic of our tertiary center for any reason between 01.10.2018 and 01.10.2020 were screened and patients whose serum glucose, ALT, creatinine, Vitamin D, and magnesium values were all present at the same time were selected. Pregnant and lactating women, patients with malignancy, chronic renal failure, hyperparathyroidism, or hypoparathyroidism, and patients under vitamin D or magnesium supplementation were excluded. Age, gender, and laboratory data of the included patients were recorded.
Results: A total of 5982 patients, 1197 male and 4785 female, were included in this study. The mean age of the cases was 42 years. There was no statistically significant relationship between Vitamin D values and magnesium or glucose levels However, there was a statistically significant relationship between serum vitamin D levels and age and serum creatinine and ALT levels. Both vitamin D and magnesium levels in women were found to be statistically significantly lower than in men.
Conclusion: Since there was no relationship between Vitamin D and magnesium levels, there is no need for a routine magnesium examination to be performed in patients with vitamin D deficiency or insufficiency who are planned to take vitamin D therapy.

References

  • Dobson R, Cock HR, Brex P, Giovannoni G. Vitamin D supplementation. PractNeurol. 2018;18:35-42.
  • Erem S, Atfi A, Razzaque MS. An abolic effects of vitamin D and magnesium in aging bone. J Steroid BiochemMol Biol. 2019;193:105400.
  • Goltzman D. Functions of vitamin D in bone. Histochem Cell Biol. 2018;149:305-12.
  • Öksüz A, Kutlu R. Meram Tıp Fakültesi Hastanesi Aile Hekimliği Polikliniğine başvuran hastaların D vitamin düzeylerinin değerlendirilmesi. Konuralp Tıp Dergisi. 2018;10:160-4.
  • Holic MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention Rev EndocrMetabDisord. 2017;18:153-65.
  • Zmijewski MA. Vitamin D and human health. Int J MolSci. 2019;20:145.
  • Capozzi A, Scambia G, Lello S. Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletalhealth. Maturitas. 2020;140:55-63.
  • Uwitonze A.M, Razzaque M.S. Role of magnesium in vitamin D activation and function. J Am Osteopath Assoc. 2018;118:181-9.
  • AllgroveJ. Physiology of calcium, phosphate, magnesium and vitamin D. Endocr Dev. 2015;28:7-32.
  • Razzaque MS. Magnesium: are we consuming enough? Nutrients. 2018;10:1863.
  • Rosanoff A, Dai Q, Shapses SA. Essential nutrient interactions: does low or suboptimal magnesium status interact with vitamin D and/or calcium status? AdvNutr. 2016;7:25–43.
  • LeFevre ML, LeFevre NM. Vitamin D screening and supplementation in community-dwelling adults: common questions and answers. Am Fam Physician. 2018;15:254-60.
  • Forrest H. Nielsen, LuAnn K. Johnson, Huawei Zeng. Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnes Res. 2010;23:158-68.
  • Reddy P,Edwards L. Magnesium supplementation in Vitamin D deficiency. Am J Ther. 2019;26:e124-32.
  • DaiQ, ZhuX, Manson J, Song Y, Li X , Franke A et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J ClinNutr.2018;108:1249-58.
There are 15 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Semih Kalyon 0000-0003-4207-0800

Early Pub Date July 9, 2023
Publication Date July 2, 2023
Acceptance Date May 18, 2023
Published in Issue Year 2023 Volume: 48 Issue: 2

Cite

MLA Kalyon, Semih. “Relationship Between Vitamin D and Magnesium”. Cukurova Medical Journal, vol. 48, no. 2, 2023, pp. 402-8, doi:10.17826/cumj.1184194.